Metabotropic Glutamate Receptor Structures Uncover Mechanisms of Class C GPCR Dimerization and Activation
In two back-to-back studies published in Nature on June 16, a team of scientists led by WU Beili, ZHAO Qiang, WANG Ming-Wei and LIU Hong at Shanghai Institute of Materia Medica，in collaboration with research groups, determined six cryo-electron m...
2021-06-16 All →
Scientists Discover Therapeutical Potential of Adoptive Treg Cell Transfer in Rescuing MIA-induced Behavioral Abnormalities
Scientists established a novel animal model of parasite-mimicking maternal immune activation (MIA), revealed immuno-neurological mechanisms underlying MIA-induced behavioral abnormalities and demonstrated therapeutic efficacy of adoptive Treg cell...
2021-04-21 All →
Researchers Reveal How Lipids and Water Molecules Regulate 5-HT Receptors
Serotonin, or 5-hydroxytryptamine (5-HT), is a kind of neurotransmitter. 5-HT can regulate multifaceted physiological functions such as mood, cognition, learning, memory, and emotions through 5-HT receptors. 5-HT receptors are a type of G protein-...
2021-03-25 All →
Scientists Reveal How Dopamine and Its Activity Regulator Bind to Dopamine Receptor D1
On March 9, 2021, scientists from an international joint team reported the near-atomic structure of dopamine receptor D1 bound with dopamine. In addition, they revealed also the high-resolution structure of D1R with its positive allosteric modulat...
2021-03-22 All →
Anti-SARS-CoV-2 Drug Candidate DC402234 Developed by SIMM Enters Clinical Trial in US
On March 15, 2021, Phase I clinical trial of anti-SARS-CoV-2 drug candidate DC402234 (FB2001) mainly developed by a research team at the Shanghai Institute of Materia Medica of Chinese Academy of Sciences (SIMM) was initiated at the Frontage Phase...
2021-03-15 All →
Researchers reveal key regulatory elements of lysine β-hydroxybutyrylation
Short-chain fatty acids sit at the crossroads of multiple metabolic pathways and play important roles in diverse cellular processes .However , key elements for regulating this physiology-relevant pathway remain unknown , hindering the functional s...
2021-02-25 All →