Seminar

Lecture 1: Heparanase: one molecule with multiple functions in cancer, inflammation and diabetic nephropathy

Lecturer:　  Prof. Israel Vlodavsky

Rappaport institute, Israel

Lecture 2:  Heparan sulfate-protein interaction-a target for treatment of Alzheimer’s disease?

Lecturer:　 Prof. Jinping Li

Uppsala University, Sweden

Host:　　 Professor Kan Ding
Time:　  09:30AM, April 20, 2011 (Wednesday)
Venue:  Yisheng Hall, No.1Building, SIMM

Welcome to attend!

Brief introduction

Prof. Vlodavsky team aims to elucidate heparanase regulation (i.e., gene expression, processing and activation, secretion and cellular uptake) and mode of action in tumor progression and inflammation in order to develop anti-heparanase therapeutic modalities with minimal side effects. An important objective of our research is to target heparanase gene transcription, post-translational modification and enzymatic activity.

Prof. Li’s team mainly aimed at elucidating the functional properties of heparan sulfate (HS) during animal development and homeostasis as well as the roles that HS plays in amyloid-related and tumor pathological processes. These goals are approached through investigating the metabolism of HS with focus on two critical enzymes, glucuronyl C5-epimerase that is a key enzyme in HS biosynthesis, and heparanase that is involved in HS degradation.