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Scientists First Analyzed the High-resolution Structure of de novo DNA Methyltransferase and Nucleosome
DNA methylation can be inherited to the offspring DNA along with the DNA replication process which makes it an important epigenetic mechanism .The DNMT3A2 catalytic domains do not contact the nucleosome core but rather follow the path of the linker DNA , interact with the linker DNA and methylate the linker DNA . Despite the conserved catalytic domains in the DNMT3 family .
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