Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Scientists Discover How G protein-coupled Receptor Kinases Recognize and Phosphorylate G protein-coupled Receptors
G protein-coupled receptor kinases ( GRKs ) play pivotal roles in the desensitization of G protein-coupled receptors ( GPCRs ) signaling .CAS made progresses in discovering the key components for the rhodopsin / GRK1 interaction and provide a framework for understanding GRK-mediated desensitization of GPCRs . The finding has been published in the Cell Research . GPCRs play fundamental roles in a broad spectrum of physiological processes and are involved in blood-related diseases .
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