Chemokine Receptor CCR5 Structures Uncover Mechanism of Chemokine Recognition and Receptor Activation

Recently , Chinese scientists reported three cryo-electron microscopy structures of Gi1 protein-coupled CCR5 in a ligand-free state and in complex with the chemokine MIP-1 α or...

Acidity-Activatable Dynamic Nanoparticles Boost Ferroptotic Cell Death for Cancer Immunotherapy

In a study published in Advanced Materials, a team of researchers led by YU Haijun from Shanghai Institute of Materia Medica, Chinese Academy of Sciences, proposed acidity-activ...

Metabotropic Glutamate Receptor Structures Uncover Mechanisms of Class C GPCR Dimerization and Activation

In two back-to-back studies published in Nature on June 16, a team of scientists led by WU Beili, ZHAO Qiang, WANG Ming-Wei and LIU Hong at Shanghai Institute of Materia Medica...