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Elegant Antibody Nanoparticles Override Immunological Tolerance of Tumors
Immune checkpoint blockade (ICB) therapy using the antibody that combats the programmed cell death ligand 1 (PD-L1) shows great potential and is causing a revolution in clinical cancer management. Unfortunately, only a subset of treated patients responds to current ICB therapies, likely due to the immunological tolerance of tumors. Therefore, developing a practical strategy to combat this immunological tolerance and amplify ICB therapies has become a priority. To meet this challenge, scientists from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences have developed a tumor enzymatic microenvironment-activatable antibody nanoparticle for robust cancer immunotherapy. This research was published online in Science Immunology.
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