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Researchers Reveal Structural Basis of Bile Acid Receptor Activation and Ligands Recognition
Playing a central role in the liver-bile acids-microbiota axis , bile acids and their receptors are the research hot spot in biomedical fields .Constitute a fingerprint reader to discriminate the interactions between different bile acids and GPBAR . Besides , the team discovered a second binding pockets for allosteric bile acid binding .Scientists discovered that the intracellular side of TM3 - 5 of GPBAR form a second bile acid binding pocket , many bile acids with 12 - OH structure could bind to this pocket and regulate receptor activation with ligand in the orthosteric pocket .
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