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SciBX highlighted the novel selective DNMT1 inhibitors identified by SIMM
Within cancer cells, alterations in DNA methylation may lead to promoter hypermethylation at CpG islands and then silence tumor suppressor genes. The inhibition of DNA methyltransferase (DNMT) activity can reactivate silenced tumor suppressor genes, which means DNMT inhibitors have become useful tools to revert cancer cells. Epigenetic modifications such as DNA methylation, histone methylation, and histone acetylation play essential roles in all aspects of biology. Among all the epigenetic events, DNA methylation is among the best-known epigenetic markers and participates in gene expression control.
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