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Glucagon Receptor Structures Reveal G protein Specificity Mechanism
G protein-coupled receptors ( GPCRs ) play essential roles in cell signal transduction and serve as important therapeutic targets for a large number of diseases .Upon binding to extracellular agonists , GPCRs stimulate various signaling pathways by recruiting different G proteins ( Gs , Gi , Gq , etc . ) to mediate a wide variety of physiological functions .The selective coupling between a GPCR and specific G proteins is critical for the biological action of the receptor .
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