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Highly Enantioselective Access to Functionalized Organoboranes via Carbene-mediated Asymmetric B-H Insertion
A unique rhodium(I)-catalyzed asymmetric B–H insertion of α-diazo carbonyl compounds with easily available amine–borane adducts was achieved using a newly developed C1-symmetric chiral diene as ligand. This first Rh(I)–carbene-directed B–H insertion example represents an attractive and promising approach for synthesis of highly enantioenriched organoboron compounds, allowing for the efficient construction of α-boryl esters and ketones with excellent enantioselectivities (up to 99% ee) under exceptionally mild conditions.
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