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Scientists Reveal New Functions of USP21 in ESCs by Regulating Nanog Stability
Nanog is a master pluripotency factor of embryonic stem cells ( ESCs ) .These findings provide a regulatory mechanism by which extrinsic signals regulate mESC fate via deubiquitinating Nanog . The ubiquitin-dependent proteasome is one of the key systems that regulate cellular protein level , cell function and cell fate .The discovery of the new functions of deubiquitinase USP21 in ESCs may lead to deeper understanding of stem cell fate determination , more efficient ways of somatic cell reprogramming , and possibly new therapies targeting cancer stem cells .
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