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Scientists made breakthrough in studies on the conformational states of full-length glucagon receptors
The internationally renowned scientific journal Nature Communications online published the full-length conformational states of glucagon receptors on July 31 .In combination with electron microscope , hydrogen deuterium exchange , disulfide bond cross-linking and mass spectrum techniques , the model was validated by receptor binding and functionality assays .The knowledge gained in this study is of importance for eventual determination of full-length structures , functional analyses and drug discovery of glucagon receptor and other class B G-protein-coupled receptors ( GPCRs .
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