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Targeting PI3Kδ for pediatric B-ALL treatment
B-cell acute lymphoblastic leukemia (B-ALL) is predominantly a childhood disease with approximately 75% of patients younger than 6 years of age. Currently, chemotherapy including VCR, DNR and Ara-C constitutes the major components of treatments, which is limited by its intolerable side effects. PI3Kδ, which is largely enriched in the hematopoietic system, is hyper-activated in most B-cell lymphoblastic leukemia and has attracted increasing interest as a target for therapy in B-cell leukemias.
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