Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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SIMM discovers that blocking autocrine VEGF signaling promotes self-renewal of mESCs
LIF is a common cytokine used to support the self-renewal of mESCs .Here we found that even in medium supplemented with LIF , mESCs still tend to differentiate toward meso-endoderm lineages after long-term culture and the culture spontaneously secretes vascular endothelial growth factors ( VEGFs ) .Blocking VEGF signaling with sunitinib or other small molecules help to maintain the mESCs in the ground state of pluripotency .
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