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Scientists Uncover Structural Basis for Glucocorticoid Hormone Recognition by Adhesion Receptor GPR97
The orphan receptor GPR97 is a member of the adhesion GPCR (aGPCR) family. As one of the evolutionarily ancient families in the GPCR superfamily, aGPCRs are crucial molecular switches that regulate many physiological processes, including brain development, ion-water homeostasis, inflammation, and cell-fate determination. Compared with other GPCR families, aGPCRs are well-known for the presence of a large ectodomain that contains the GAIN domain, which functions with the seven-transmembrane (7TM) bundle as a pair, and subsequent activation of the receptor through tethered agonism or other mechanisms such as mechanical force. However, the structural basis for aGPCR activation is unclear and whether the 7TM bundle of aGPCR constitutes a typical pocket to recognize a small chemical ligand is uncertain.
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