Structural Basis for Inhibiting HBV via HBx–Smc6 Interface: A New Therapeutic Direction

Chronic hepatitis B virus (HBV) infection remains a major global health challenge, affecting approximately 250 million people worldwide, with about 80 million in China. Chronic infection is difficult to cure and often leads to cirrhosis and hepato...

2026-04-30 All →

Researchers Enable Small-Molecule-Mediated Precision Protein Editing in Living Cells

While genome editing technologies have revolutionized biology, a key gap remains: the lack of methods for direct, site-specific single amino acid editing in endogenous proteins. The ability to directly and precisely manipulate native proteins with...

2026-04-21 All →

Scientists Discover that IL-22 Supports Long-Term Expansion of Mouse and Human Hepatocytes

Hepatocytes have wide applications in drug development, disease modeling, and cell therapy. However, expanding hepatocytes in large quantities in vitro without compromising their functions remains a significant challenge. Previously, a few studies...

2026-03-25 All →

Natural Polysaccharides Uptake in Intestinal Cells Relies on Clathrin/Dynamin1/Rab5-Dependent Endocytosis

Natural polysaccharides demonstrate diverse notable pharmacological activities including anti-tumor, immunomodulatory, antiviral, hypoglycemic, and anti-aging, with relatively low toxicity. Hence, natural polysaccharides are considered as promisin...

2026-03-12 All →

Scientists Develop Cytoplasmic ssDNA–LNP System for Longer-Lasting Antigen Expression

Lipid nanoparticles (LNPs) have become a leading delivery platform for nucleic-acid medicines, particularly messenger RNA (mRNA). Yet mRNA can be unstable in the cytoplasm, and protein expression often declines within about 24 hours. Self-amplifyi...

2026-03-10 All →

Scientists Unveil an Oral Drug Candidate VV261 against Chikungunya Virus

Chikungunya virus (CHIKV) is a mosquito-borne, positive-sense RNA virus that causes high fever and severe joint pain. Since 2004, CHIKV outbreaks have become more frequent and widespread. In July 2025, Guangdong province in China reported more tha...

2026-03-05 All →