Chemokine Receptor CCR5 Structures Uncover Mechanism of Chemokine Recognition and Receptor Activation

Recently , Chinese scientists reported three cryo-electron microscopy structures of Gi1 protein-coupled CCR5 in a ligand-free state and in complex with the chemokine MIP-1 α or RANTES , as well as the crystal structure of MIP-1 α - bound CCR5 .C...

2021-07-09 All →

Acidity-Activatable Dynamic Nanoparticles Boost Ferroptotic Cell Death for Cancer Immunotherapy

In a study published in Advanced Materials, a team of researchers led by YU Haijun from Shanghai Institute of Materia Medica, Chinese Academy of Sciences, proposed acidity-activatable dynamic nanoparticles to boost ferroptosis and immunogenic deat...

2021-07-09 All →

Metabotropic Glutamate Receptor Structures Uncover Mechanisms of Class C GPCR Dimerization and Activation

In two back-to-back studies published in Nature on June 16, a team of scientists led by WU Beili, ZHAO Qiang, WANG Ming-Wei and LIU Hong at Shanghai Institute of Materia Medica，in collaboration with research groups, determined six cryo-electron m...

2021-06-16 All →

Scientists Discover Therapeutical Potential of Adoptive Treg Cell Transfer in Rescuing MIA-induced Behavioral Abnormalities

Scientists established a novel animal model of parasite-mimicking maternal immune activation (MIA), revealed immuno-neurological mechanisms underlying MIA-induced behavioral abnormalities and demonstrated therapeutic efficacy of adoptive Treg cell...

2021-04-21 All →

Scientists Discover Therapeutical Potential of Adoptive Treg Cell Transfer in Rescuing MIA-induced Behavioral Abnormalities

Scientists established a novel animal model of parasite-mimicking maternal immune activation (MIA), revealed immuno-neurological mechanisms underlying MIA-induced behavioral abnormalities and demonstrated therapeutic efficacy of adoptive Treg cell...

2021-04-20 All →

Researchers Reveal How Lipids and Water Molecules Regulate 5-HT Receptors

Serotonin, or 5-hydroxytryptamine (5-HT), is a kind of neurotransmitter. 5-HT can regulate multifaceted physiological functions such as mood, cognition, learning, memory, and emotions through 5-HT receptors. 5-HT receptors are a type of G protein-...

2021-03-25 All →