Aberrant Mitochondrial ClpP Activation Suppresses Pancreatic Ductal Adenocarcinoma

In a recent study published in Cell Chemical Biology, a team of researchers led by YANG Cai-Guang from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, has reported a novel and active ClpP activator, and conceptually verifi...

2022-09-27 All →

Antioxidant Biodegradable Carrier Developed for Pulmonary Drug Delivery

In a study published in ACS Applied Materials & Interfaces, the team of ZHANG Jiwen from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Science, in collaboration with LI Zegeng from the First Affiliated Hospital of Anhui...

2022-09-27 All →

Review: Recent Advance on Chemistry, Chemical Ecology, and Therapeutical Potential of Marine Mollusks

On August 9, the marine drug research group leading by Prof. GUO Yue-Wei from Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences, published a review paper in Nat. Prod. Rep., summarizing the recent advance on the intere...

2022-09-09 All →

Researchers Discovered Water-Soluble Zolinium Selectively Modifying Lysine Residues of Peptides and Proteins

In a study published in J. Med. Chem, LI Bo and ZHU Weiliang from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, together with Prof. GE Guangbo from Shanghai University of Traditional Chinese Medicine, designed and de...

2022-09-01 All →

Researchers Reveal Molecular Mechanism of Hepatic Bile Acid Metabolism Affecting Intestinal Barrier Renewal

Intestinal epithelial barriers , that include both physical and chemical barriers , segregate gut commensal microbes and the host immunity to maintain intestinal homeostasis .Previous studies have shown that BAs are important regulators of intesti...

2022-08-31 All →

Study Revealed Ligand Recognition Mechanism of Orphan Receptor GPR119

Metabolic diseases , including diabetes , fatty liver , and obesity , have become a major " killer " affecting human health .However , drug discovery of GPR119 is limited by the lack of structural understanding of the recognition of ligands to the...

2022-08-18 All →