Researchers Reveal How Gatekeeper Enzyme UGCG Controls Glycosphingolipid Synthesis

Glycosphingolipids (GSLs) are sugar-containing membrane lipids that help organize cell surfaces and regulate signaling, immune recognition, differentiation and neuronal function. Human cells produce several hundred GSL species through stepwise mo...

2026-08-27 All →

Researchers Reveal a Novel Mechanism Where Iron-Driven Protease-Independent Cleavage of GSDMD Promotes Allergic Airway Inflammation

Allergic airway inflammation is a key pathological basis for the onset and progression of asthma. When environmental allergens such as pollen, house dust mites, and fungal proteases enter the airway, they first act on lung epithelial cells and ind...

2026-07-24 All →

SIMM hosted a cross-cultural exchange activity for Chinese and international students titled "Charming Cities, Splendid China: A Tapestry of Culture and Heritage."

On July 3, 2026, the Graduate Education Office and the International and Domestic Cooperation Department of the Shanghai Institute of Materia Medica jointly hosted the "Charming Cities · Splendid China" event as part of the "Encounter China, Shin...

2026-07-13 All →

Adv Sci | Rational Design of Broad-Spectrum Anti-Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Traditional antiviral drugs mostly act through an ‘occupancy-driven’ mode of action, in which they inhibit viral infection by occupying functional sites on viral or host targets. However, these drugs still face challenges such as drug resistance...

2026-07-07 All →

Researchers Reveal Structural Basis of Long-Range Transcription-Translation Coupling in Bacteria

Transcription and translation are the core processes of gene expression. In bacteria, these two processes occur in the same cellular compartment, occur at the same time, and in many cases, are functionally coordinated and physically coupled. This ...

2026-07-07 All →

Researchers Develop Plant Vesicle-DC Chimera to Reverse Mitochondrial Dysfunction in Cancer Immunotherapy

Tumors create a hostile environment that disables dendritic cells (DCs), the key activators of T-cell responses. Within tumors, hypoxia fragments DC mitochondria, triggers endoplasmic reticulum stress, and promotes lipid droplet accumulation, all ...

2026-07-01 All →