Headline
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TranSiGen: Novel Deep Generative Model for Phenotype-based Drug Screening
Phenotype-based screening is crucial for drug discovery , focusing on comprehensive cellular responses to drug candidates .Including ligand-based virtual screening , drug response prediction , and phenotype-based drug repurposing .Demonstrated the...
2024-06-28 All →
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Innovative Drug Gumarontinib has been Successfully Approved in Japan
The global leading principal investigator is Prof . SHUN Lu from Shanghai Chest Hospital . A total of 79 patients with MET exon 14 skipping mutations confirmed by the central laboratory were enrolled in the GLORY study , with data cut-off on April...
2024-06-28 All →
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Researchers Develop Highly Accurate Carbohydrate Binding Site Prediction Algorithm DeepGlycanSite
As the most abundant organic substances in nature , carbohydrates are essential for life .Introduced a new carbohydrate-binding site predictor DeepGlycanSite . This predictor remarkably outperforms previous state-of-the-art methods and effectively...
2024-06-21 All →
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Researchers Unveil Molecular Mechanisms of Somatostatin Receptor 5 Activation by Neuropeptides and Drugs
A research team led by Eric H. Xu (XU Huaqiang) and ZHAO Lihua from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences, employed single-particle cryo-electron microscopy techniques to unveil three-dimensional struct...
2024-06-19 All →
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Advancing Chemical Text Mining: Fine-Tuning Large Language Models for Knowledge Extraction
Chemical literature contains a wealth of data , and extracting key chemical information through text mining techniques to build extensive databases can provide experimental chemists with detailed physical and chemical properties and synthesis rout...
2024-06-17 All →
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Chemical conjugation mitigates immunotoxicity of chemotherapy of Lipid Nanoparticles
While chemotherapy can stimulate antitumor immunity , it may also impair immune cell function and induce lymphodepletion , reducing effectiveness of subsequent immunotherapy .This resulted in lower toxicity against myeloid cells than ED-sHDL via a...
2024-06-11 All →