Study of Small Molecules with Blood–Brain Barrier Penetrability for NIR-II Fluorescent Noninvasive Brain Imaging

NIR-II dyes with large molecular frameworks still have limited applications for brain imaging since the blood ？ brain barrier ( BBB ) prevents most molecules from entering the central nervous system .The researchers observed the process of dyes d...

2023-01-13 All →

Researchers Reveal the Ligand-Recognition Mode of Adenosine Receptor A_2BR

Adenosine ( ADO ) is ubiquitously distributed in human tissue and organ and regulates a multitude of physiological and pathological processes .The structures demonstrated a conserved adenosine-binding mode and provide a template for understanding ...

2023-01-13 All →

Mapping Lactylome in Hepatocellular Carcinoma Revealed New Mechanisms of Metabolic Adaptation

Lactate , a major product of glycolysis in mammals , is significantly increased in pathological states such as tumors , sepsis and autoimmune diseases , which is known as the Warburg effect .Performed the first lactylome analysis of an HCC cohort ...

2023-01-04 All →

Viral Surface-inspired Nanocarriers Developed for Improved Oral Insulin Therapy

Diabetes , a chronic metabolic disease , has seriously threatened the life of patients .Clinically , type 1 diabetes ( T1DM ) and advanced type 2 diabetes ( T2DM ) patients require multiple daily insulin injections to maintain blood glucose levels...

2022-12-01 All →

Cytokine IL6 May Support Long-term Expansion of Hepatocytes in vitro

Liver is the primary metabolic organ in mammals .During homeostasis , the liver cells generally have a low turnover rate .Comparing to the robust proliferation capacity in vivo , adult hepatocytes have been proven to be extremely difficult to cult...

2022-12-01 All →

Chinese Scientists Show How Fentanyl and Morphine Act on μ Opioid Receptor

Pains , especially the chronic pains , are common neurological disorders .The most common chronic pain conditions mainly include low back pain , arthritis pain , migraine and cancer pain , which seriously affect our physical and mental health .And...

2022-11-14 All →