Researchers Discover YTHDF2 Inhibition Potentiate Radiotherapy Anti-Tumor Efficacy

In a study published in Cancer Cell on May 26, a team of researchers led by LUO Cheng from Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences, in collaboration with groups led by CHUAN He, Ralph R Weichselbaum and Hua L...

2023-05-25 All →

New Approach to Spatiotemporally and Globally Profile DNA–Protein Interactions Enabling Discovery of Low-Affinity Transcription Factors

DNA-protein interactions are essential components of biological systems , playing a crucial role in various biological processes .Global profiling of weak and dynamic DNA-protein interactions remains highly challenging . ？ Covalent capturing of D...

2023-05-05 All →

Researchers Discover Novel Mechanisms of AMPK epigenetically Suppressing Cancer Metastasis

Lung cancer is highly susceptible to metastasis .Epithelial to mesenchymal transition ( EMT ) has been implicated as a driver in the dissemination of cancer cells .Epithelial genes were stably inhibited ( marked by H3K27me2 / 3 , H3K9me2 / 3 and D...

2023-03-21 All →

Researchers Decode Recognition Mechanism of MTLR by Motilin and Macrolide Antibiotics

In a study published in Science Advances, a team of researchers led by H. Eric XU (XU Huaqiang) from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences and JIANG Yi from LinGang Laboratory resolved two high-resolution cryo-EM ...

2023-03-20 All →

NMPA Conditionally Approves Gumarontinib for Treatment of Non-Small Cell Lung Cancer with MET Exon 14 Skipping Mutation

On March 8, 2023, the National Medical Products Administration (NMPA) of China conditionally approved Gumarontinib for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with MET exon 14 skipping...

2023-03-08 All →

Scientists Discover Small Molecule Drugs Promote Repopulation of Transplanted Hepatocytes by Stimulating Cell Dedifferentiation

Liver transplantation is so far the only known way to treat end-stage liver diseases .It is important to explore the mechanisms of hepatocyte proliferation in vivo and to find a way to promote the growth of transplanted hepatocytes . ？ In a recen...

2023-02-24 All →