Researchers Uncover Molecular Mechanism of Methamphetamine Binding to Trace Amine Receptor TAAR1

Methamphetamine ( METH ) abuse is a major health concern , however , there are no FDA-approved treatments .Understanding how METH interacts with its target proteins is crucial for the development of novel medications to address drug addiction .The...

2023-11-22 All →

Efficient Prediction of Relative Ligand Binding Affinity in Drug Discovery

In a study published in Nature Computational Science on October 19, a team of researchers led by Prof. ZHENG Mingyue from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences developed a pairwise binding comparison ne...

2023-10-23 All →

Glucagon Receptor Structures Uncover a New Arrestin Interaction Mechanism

In a study published in Nature on August 9, a research group led by WU Beili and ZHAO Qiang at the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences (CAS) determined the cryo-electron microscopy (cryo-EM) structures of...

2023-08-08 All →

Chinese Scientists Discover Conserved and Druggable Pocket for Small Molecule Agonists in Class B GPCRs

In a study published in Nature on July 31, teams of researchers led by H. Eric XU (XU Huaqiang) and ZHAO Lihua from the Shanghai Institute of Materia Medica (SIMM), theChinese Academy of Sciences (CAS), made a breakthrough discovery in the activat...

2023-07-31 All →

Researchers Revealed Novel Lysine Modification-Lysine Acetoacetylation

Intracellular metabolites occupy a pivotal position in numerous metabolic pathways and play crucial roles in diverse cellular processes .They identified Kacac as a dynamic post-translational modification regulated by HBO1 . In this study , the res...

2023-07-04 All →

Research Reveals How Bacteroides Xylanisolvens Survives in Human Gut

Xylan is crucial for shaping the composition of human gut microbiota .Hence , it is crucial to firstly clarify the molecular mechanism of xylan degradation by human gut microbiota . ？ In a study published in Carbohydrate polymers on May 19 .These...

2023-06-16 All →