Researchers Revealed Proteogenomic Characterization for Intrahepatic Cholangiocarcinoma

In a study recently published in Cancer Cell, ZHOU Hu’s team from Shanghai Institute of Materia Medica, the Chinese Academy of Sciences, collaborated with FAN Jia and GAO Qiang’s team from Zhongshan Hospital, Fudan University; and GAO Daming’s ...

2022-01-07 All →

Researchers Constructed Novel PET and Fluorescence Bimodal Small-Molecule Probes for Myocardial Imaging

In a study published in Journal of Medicinal Chemistry on Dec. 22, researchers led by CHENG Zhen and CHEN Hao from Molecular Imaging Center of Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, developed mitochondria-targetin...

2022-01-07 All →

Novel DDRs Inhibitors Developed for Treating Idiopathic Pulmonary Fibrosis

In a study recently published in Acta Pharmaceutica Sinica B, a team of researchers led by LI Jia and XIONG Bing from Shanghai Institute of Materia Medica of Chinese Academy of Sciences developed a series of novel DDRs inhibitors with potent in vi...

2021-12-15 All →

TMEM201: Researchers Reveal Inner Nuclear Membrane Protein as Positive Regulator in Breast Cancer Metastasis

Nuclear envelope ( NE ) is composed of outer and inner membranes ( ONM and INM , respectively ) , which are separated by the perinuclear space and joined at nuclear pore complexes .However , the specific INM proteins and INM protein-based mechanis...

2021-12-07 All →

Researchers Develop HTMR Assay for DNA/RNA Methyltransferases and Demethylases Activity Detection

DNA methylation ( 5mC ) and RNA methylation ( m6A ) are widely present in animals , plants , fungi , and prokaryotes , which play important roles in a variety of life processes .A team of researchers led by LUO Cheng from Shanghai Institute of Mat...

2021-11-09 All →

Researchers Reveal Assembly Program and Activation Mechanism of K63-polyUb Mediated MDA5-MAVS Antiviral Signal Pathway

MDA5 is an allogeneic RNA monitoring protein in cells and an important member of RIG-I - like receptor family ( RLRs ) .ZHENG Jie ' s group of Shanghai Institute of Materia Medica , Chinese Academy of Sciences revealed the molecular mechanism that...

2021-10-25 All →