Headline
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Spatiotemporal and Direct Capturing Global Substrates of Post-Translational Modifying Enzymes in Living Cells
The potential and capability of PTM-mechanism-guided direct capturing global substrates presents an exciting prospect but yet largely unexplored. In a study published in Nature Communications on February 17 .The concept of direct capturing substr...
2024-04-07 All →
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Researchers Develop Probe for In-Depth N-Terminomics Detection
Proteolysis , an essential and irreversible process conducted by proteases , is fundamental to a wide range of biological functions .The utilization of the 2PCA-Probe as a tool for identifying N-terminal chemical labeling marked a pivotal point in...
2024-03-14 All →
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Researchers Reveal Comprehensive Proteogenomic Landscape of Human Small Cell Lung Cancer
Small cell lung cancer ( SCLC ) is the most malignant and deadliest subtype of lung cancer , which kills over 200000 people worldwide each year .01335 - 1 proteogenomic landscape of small cell lung cancer ( Image by SIMM ) Contact : DIAO WentongSh...
2024-01-18 All →
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Researchers Uncover Molecular Mechanism of Methamphetamine Binding to Trace Amine Receptor TAAR1
Methamphetamine ( METH ) abuse is a major health concern , however , there are no FDA-approved treatments .Understanding how METH interacts with its target proteins is crucial for the development of novel medications to address drug addiction .The...
2023-11-22 All →
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Efficient Prediction of Relative Ligand Binding Affinity in Drug Discovery
In a study published in Nature Computational Science on October 19, a team of researchers led by Prof. ZHENG Mingyue from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences developed a pairwise binding comparison ne...
2023-10-23 All →
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Glucagon Receptor Structures Uncover a New Arrestin Interaction Mechanism
In a study published in Nature on August 9, a research group led by WU Beili and ZHAO Qiang at the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences (CAS) determined the cryo-electron microscopy (cryo-EM) structures of...
2023-08-08 All →