CN |CAS  
 
  Home | Links | Site map
 
Home About Us News Organization Research Faculty Publication Education&Training Contact
  Research
Location: Home > Research
 
 
Research
Target
Discovery
Development
Translation
 
Pharmacokinetic studies on herbal medicine Sanqi published as cover paper
Update time: 2010-01-13
Close
Text Size: A A A
Print

  

  

  The systematic studies on pharmacokinetics of the herbal medicine Panax notoginseng (Sanqi) was published in the recent issue of Drug Metabolism and Disposition(DMD, 2009, 37: 2290-2298), and was highlighted as the cover paper. The study was completed by Dr Chuan Li’s group of Shanghai Institute of Materia Medica.

  How to evaluate the systematic exposure of the body to the multi-component herba, and how to study the structure-pharmacokinetics relationship are the two key scientific issues to perform pharmacokinetic research on an herbal medicine. Focusing on these two issues, the study elucidated the pharmacokinetic properties of the active ginsenosides and identified the pharmacokinetic markers (PK markers) in the PK study with rats treated with oral administration of Sanqi extract. The research group also studied the structure-pharmacokinetics of saponins, and found the key factors leading different absorption and disposition behaviors among different ginsenosides.

  PK marker is a new concept firstly presented by Dr Chuan Li’s group (DMD 2008, 36: 1578–1586) to evaluate the systemic exposure of the body to the multi-component herb. It has provided a new strategy to comprehensive pharmacokinetic studies on herbs.

 
weimoban
About Us News Research Faculty Education&Trainning Organization Contact
Brief Introduction
History
Address from the Director
Directors
Administration
Research
Events
Int'l cooperation
Target
Discovery
Development
Translation
Academician
PI
Graduate Students
Post Graduate Students