Researchers Reveal a Pressure Sensing and Modulating Mechanism Underpinning Genome Packaging, Retention and Ejection in Herpesviruses

The researchers from Dr. YU Xuekui’s group at the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences resolved the in situ structures of the portal and the capsid vertex-specific components (CVSC) of HCMV

2021-07-31 All →

Researchers Discover Structural Basis of Antidepressant Ketamine Action on Human NMDA Receptors

A recent study published in Nature revealed the structural basis of antidepressant ketamine action on human NMDA receptors. This work has provided the structural basis of ketamine binding and action on human NMDA receptors, and paved the way for f...

2021-07-29 All →

Researchers Highlight Non-invasive Design Strategy Underlying Organ Disease Biomarkers

Recently, in a tutorial review published in Chemical Society Reviews, researchers highlighted the design strategy that underlies the preparation of various promising probes, their optical response to key biomarkers, and proof-of-concept biological...

2021-07-29 All →

Chemokine Receptor CCR5 Structures Uncover Mechanism of Chemokine Recognition and Receptor Activation

Recently , Chinese scientists reported three cryo-electron microscopy structures of Gi1 protein-coupled CCR5 in a ligand-free state and in complex with the chemokine MIP-1 α or RANTES , as well as the crystal structure of MIP-1 α - bound CCR5 .C...

2021-07-09 All →

Acidity-Activatable Dynamic Nanoparticles Boost Ferroptotic Cell Death for Cancer Immunotherapy

In a study published in Advanced Materials, a team of researchers led by YU Haijun from Shanghai Institute of Materia Medica, Chinese Academy of Sciences, proposed acidity-activatable dynamic nanoparticles to boost ferroptosis and immunogenic deat...

2021-07-09 All →

Metabotropic Glutamate Receptor Structures Uncover Mechanisms of Class C GPCR Dimerization and Activation

In two back-to-back studies published in Nature on June 16, a team of scientists led by WU Beili, ZHAO Qiang, WANG Ming-Wei and LIU Hong at Shanghai Institute of Materia Medica，in collaboration with research groups, determined six cryo-electron m...

2021-06-16 All →