Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

Prof. Dr. ZHANG Jiwen, now serves as the principal investigator in Shanghai institute of Materia Medica (SIMM), Chinese Academy of Science. He has carried out the interdisciplinary research by establishing cooperation with research team at home and abroad. His team utilized primarily the synchrotron to establish quantitative methods for characterizing the irregular and dynamic structure of DDS, and started a new area as Structure Pharmaceutics, focusing on the 3D structure of pharmaceutical dosage forms and particulate systems or excipients. His team is also specialized in supramolecular systems made of cyclodextrins, like CD-MOFs and derivative materials, for controlled release and target drug delivery systems. Aiming at the evaluation of DDS, he has established the pharmacokinetics theory for the sustained and controlled-release systems, putting forward the quantitative method for optimizing the formulation of the sustained and controlled-release systems, and has designed new formulation such as biomimetic DDS. DPI, osmotic pump systems and nano-particulate systems are the top dosage forms to this team.

Education

1997-2001, School of Pharmacy, Shenyang Pharmaceutical University, Pharmaceutics, Ph.D.

1990–1993, School of Pharmacy, China Pharmaceutical University, Pharmaceutics, M.S.

1986-1990, School of Pharmacy, Shenyang Pharmaceutical University, Pharmaceutical engineering, B.S.

1981-1984, Anqing Health School, Assistant Pharmacist

Work Experience

20xx- present, Executive Vice Director, Yangtze Delta Drug Advanced Research Institute

2019- present, Deputy Director, NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients

2007.06-present, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Professor and Principal Investigator

2005.01-2014.06, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Vice director and director for the Department of Scientific Research, secretary of the academic committee, chairman of IACUC, director of the office for the major drug innovation project management, special assistant of the director-general of the institute

2003.08-2005.01, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, postdoctoral fellow

1995.07-2003.08, New Drug Research Institute in Anhui, director

1994.06-1995.07, Hangzhou Jiuyuan Gene Engineering Co., Ltd., Manager for Manufacturing Department

1993.07-1994.06, Luoyang Pharmaceutical Factory, Assistant of the chief Engineer

1984.06-1986.09, Anhui Provincial TB Institute, Assistant Pharmacist

Research Directions

1.Structure Pharmaceutics;

2.Pharmacokinetics for controlled/sustained drug delivery systems;

3.Supramolecular drug delivery systems.

Grants & Research Projects

1.National Key R&D Program of China, Joint research on quality research and evaluation technology of drug preparations for treatment of major diseases, 2020.06-2023.05

2.National Natural Science Foundation of China, Theoretical research on structure pharmaceutics: quantitative structure of pharmaceutical preparations and its control on drug release, 2018.01-2021.12

Achievements

1. Pharmacokinetic theory of controlled release systems

We have systematically investigated the pharmacokinetic theory of the controlled/sustained release systems, and published a monograph titled as pharmacokinetics of controlled/sustained release systems (Science Press, May, 2009), which is a multidisciplinary work of pharmacokinetics and DDS as the first monograph in this field, providing theory and methodology for the quantitative design of in vitro release characteristics of DDS and in vivo pharmacokinetic evaluation.

2. Structures Pharmaceutics

Characterization methods for conventional dosage forms are mostly qualitative assessment. In our work, the synchrotron radiation facility met with the evaluation of DDS in view of the 3D and fractal dimension quantitative analysis for structure of formulations on the sub-micron and micron level. These works quantitatively correlated the release characteristics of formulations with its complex structures. Four levels of structures of formulations, namely, structure of molecules, structure of molecular assemblies, structure of particles and crystals, structure of dosage forms, were defined with 3D release theories and methods for design and optimization of DDS.

3. Study on supramolecular systems and drug release mechanism

Supramolecular systems based on cyclodextrins were studied for mechanism of the drug release kinetics. Supramolecular drug delivery systems using CD-MOF were developed for controlled release and inhalations.

4. Research on novel drug delivery systems

Based on structural innovation, new types of tablets, e.g., dynamic structural osmotic pump tablets driven by liquid droplets formed spontaneously in situ in semi-solid matrix and tablets with cage-like structures, have been designed. Dry powders for inhalers were investigated for natural product from TCMs and new compound. The team is also working on oral DDS for poorly water-soluble drugs and taste masking on bitter drugs for pediatric usages.

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Social Titles

1. Editor Member of the journals: International Journal of Pharmaceutics, Acta Pharmaceutica Sinica B, and Asian Journal of Pharmaceutics.

2. Panel Member of the UK-China Advanced Material Research Institute.

3. Member of the Pharmaceutics Committee, China Pharmaceutical Association.

4. Member of the Pharmaceutics Committee, Shanghai Pharmaceutical Association.

5. Member of the Pharmaceutical excipients Committee, China Society for drug regulation.

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Awards & Honors

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Pubilcations

Full Publication List

Selected Publications

1.Yaping He, Ting Xiong, Siyu He, Hongyu Sun, Chenxi Huang, Xiaohong Ren, Li Wu, Laurence H. Patterson, Jiwen Zhang. Pulmonary Targeting Crosslinked Cyclodextrin Metal–Organic Frameworks for Lung Cancer Therapy. Advanced Functional Materials. 2020. doi:10.1002/adfm.202004550.

2.Yuanzhi He, Wei Zhang, Tao Guo, Guoqing Zhang, Wei Qin, Liu Zhang, Caifen Wang, Weifeng Zhu, Ming Yang, Xiaoxiao Hu, Vikramjeet Singh, Li Wu, Ruxandra Gref, Jiwen Zhang. Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan. Acta Pharmaceutica Sinica B. 2019;9(1):97-106. doi:10.1016/j.apsb.2018.09.003

3.Yaping He, Jian Xu, Xian Sun, Xiaohong Ren, Abi Maharjan, Peter York, Yong Su, Haiyan Li, Jiwen Zhang. Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting. Theranostics. 2019;9(9):2489-504. doi: 10.7150/thno.31159

4.Shailendra Shakya, Yaping He, Xiaohong Ren, Tao Guo, Abi Maharjan, Ting Luo, Tingting Wang, Ramesh Dhakhwa, Balmukunda Regmi, Haiyan Li, Ruxandra Gref, and Jiwen Zhang. Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal-Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application. Small. 2019;15(27):e1901065. doi: 10.1002/smll.201901065

5.Liu Zhang, Li Wu, Caifen Wang, Guoqing Zhang, Lin Yu, Haiyan Li, Abi Maharjan, Yan Tang, Dunwei He, Peter York, Huimin Sun, Xianzhen Yin, Jiwen Zhang, Lixin Sun. Synchrotron Radiation Microcomputed Tomography Guided Chromatographic Analysis for Displaying the Material Distribution in Tablets. Analytical Chemistry. 2018;90(5):3238-44. doi: 10.1021/acs.analchem.7b04726

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