LAN Lefu
Principal Investigator;Professor/Ph.D candidate supervisor, Principal Investigator
Infectious Disease Research Center
Personal Homepage
CONTACT
llan@simm.ac.cn
+86-21-50803109
201203
555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China
Biography
Currently, I am a Principal Investigator at Shanghai Institute of Materia Medica, CAS since 2010. I received a Ph.D degree from the Institute of Genetics and Developmental Biology of CAS and finished postdoctoral training in Kansas State University and in the University of Chicago. The projects in my lab are supported by National Natural Science Foundation of China, the Chinese Academy of Sciences, Ministry of Science and Technology of the People′s Republic of China, and Science and Technology Commission of Shanghai Municipality.
EDUCATION
09/1993 - 07/1997 Sichuan University
09/1997 - 07/2000 Sichuan University
09/2000 - 03/2004 Institute of Genetics and Developmental Biology, CAS
WORK EXPERIENCE
10/2004 - 12/2006 Kansas State University
01/2007 - 05/2010 The University of Chicago
06/2010 - present Shanghai Institute of Materia Medica, CAS
Research Directions
Bacterial (S. aureus, P. aeruginosa) virulence strategies, signaling pathways, and potential ways to exploit them; Identification and validation (genetic and chemical) of drug targets; Anti-virulence drugs.
Grants & Research Projects
Achievements
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Social Titles
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Awards & Honors
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Pubilcations
Full Publication List
Selected Publications
1.Wang Y#, Di H#, Chen F, Xu Y, Xiao Q, Wang X, Wei H, Lu Y, Zhang L, Zhu J, Lan L*, Li J*. Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN). J Med Chem. 2016 May 26;59(10):4831-48.
2.Wang Y#, Chen F#, Di H, Xu Y, Xiao Q, Wang X, Wei H, Lu Y, Zhang L, Zhu J, Sheng C, Lan L*, Li J*. Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections. J Med Chem. 2016 Apr 14;59(7):3215-30. [ACS Editors' Choice？ Articles; highlighted by BioCentury Innovations, 03/31/2016].
3.Chen F#, Di H#, Wang Y#, Cao Q, Xu B, Zhang X, Yang N, Liu G, Yang CG, Xu Y, Jiang H, Lian F, Zhang N, Li J*, Lan L*. Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence. Nat Chem Biol. 2016 Mar;12(3):174-9. [Highlighted by Nature Reviews Drug Discovery, (doi:10.1038/nrd.2016.35), Bioworld Today (01/20/2016), and BioCentury Innovations (01/28/2016)].
4.Yang N, Lan L*. Pseudomonas aeruginosa Lon and ClpXP proteases: roles in linking carbon catabolite repression system with quorum-sensing system. Curr Genet. 2016 Feb;62(1):1-6.
5.Yang N, Ding S, Chen F, Zhang X, Xia Y, Di H, Cao Q, Deng X, Wu M, Wong CC, Tian XX, Yang CG, Zhao J, Lan L*. The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa. Mol Microbiol. 2015 May;96(3):526-47.
6.Ding Y, Liu X, Chen F, Di H, Xu B, Zhou L, Deng X, Wu M, Yang CG*, Lan L*. Metabolic sensor governing bacterial virulence in Staphylococcus aureus. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4981-90. [Highlighted by SciBX, 7(46); doi:10.1038/scibx.2014.1352]
7.Cao Q#, Wang Y#, Chen F, Xia Y, Lou J, Zhang X, Yang N, Sun X, Zhang Q, Zhuo C, Huang X, Deng X, Yang CG, Ye Y, Zhao J*, Wu M*, Lan L*. A novel signal transduction pathway that modulates rhl quorum sensing and bacterial virulence in Pseudomonas aeruginosa. PLoS Pathog. 2014 Aug 28;10(8):e1004340.
8.Deng X#, Liang H#, Chen K, He C, Lan L*, Tang X*. Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae. Nucleic Acids Res. 2014 Oct;42(18):11472-86.
9.陈菲菲, 狄红霞, 蓝乐夫*. 金黄色葡萄球菌重要毒力因子的功能及其抑制剂研究进展,科学通报，2013, 58: 3743-3752.
10.Liu X, Sun X, Wu Y, Xie C, Zhang W, Wang D, Chen X, Qu D, Gan J, Chen H, Jiang H, Lan L*, Yang CG*. Oxidation-sensing regulator AbfR regulates oxidative stress responses, bacterial aggregation, and biofilm formation in Staphylococcus epidermidis. J Biol Chem. 2013 Feb 8;288(6):3739-52.
11.Sun F, Ding Y, Ji Q, Liang Z, Deng X, Wong CC, Yi C, Zhang L, Xie S, Alvarez S, Hicks LM, Luo C, Jiang H, Lan L*, He C*. Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15461-6. Highlighted by Sci. Signal. DOI: 10.1126/scisignal.2003635）
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