HU Youhong
Professor/Ph.D candidate supervisor, Principal Investigator
Small-Molecule Drug Research Center
Personal Homepage
CONTACT
yhhu@simm.ac.cn
50806600-3526
201203
555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China
Biography
Education:
1994-1997 Ph.D., Organic Synthesis Chemistry Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China
1991-1994 M.S., Organometallic Chemistry, Lanzhou University, China
1987-1991 B.S., Organic Chemistry, Lanzhou University, China
Work Experience：
2017.11-Present Professor, Shanghai Institute of Materia Medica
2014.6-2017.11 Professor, Zhejiang University
2005.5-2014.6 Professor, Shanghai Institute of Materia Medica
2001.7-2005.4 Senior Scientist, VivoQuest Inc.
2001.4-2001.7 Visiting Scientist, The Aaron Diamond AIDS Research Center Rockefeller University
2000.8-2001.4 Postdoc. Researcher, Harvard Medical School, Institute of Chemistry & Cell Biology
1998.9-2000.8 Postdoc. Researcher, Drug Discovery Program, Georgetown University Medical Center
1997.9-1998.7 Visiting Scholar, Lab of Organic Chemistry, School of Agricultural Sciences, Nagoya University, Japan
Research Directions
Medicinal Chemistry and Organic Synthesis;
Chemical Biology;
Discovery and Development of New Drugs;
Design and Synthesis of Activity-based Probes for Protein Profiling and Targets Identification.
Grants & Research Projects
1.Programs supported by National Natural Science Foundation of China.
2.Major Projects in National Ministry of Science and Technology.
3.Programs supported by Shanghai Commission of Science and Technology.
Achievements
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Social Titles
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Awards & Honors
Award of Biological Drugs by Chinese Pharmaceutical Association and Sanofi-Aventis, 2010
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Pubilcations
Full Publication List
Selected Publications
1.Jingjing Chen#; Yalei Li#; Jie Zhang; Minmin Zhang ; Aihuan Wei ; Hongchun Liu ; Zhicheng Xie ; Wenming Ren ; Wenwen Duan ; Zhuo Zhang; Aijun Shen* ; Youhong Hu*; Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes, Eur. J. Med. Chem., 2020, doi: 10.1016/j.ejmech.2020.112868.
2.Congcong Wang#, Yu-Fang Zhang#, Shimeng Gu#, Quan Zhao, Yanping Zeng, Zhicheng Xie, Xin Xie*, Boxun Lu*, and Youhong Hu* ,GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntingtons Disease-Related Phenotypes, J. Med. Chem, 2020 Nov 13; doi: 10.1021/acs.jmedchem.0c01133.
3.Wuhong Chen,# Feifei Liu,# Qiliang Zhao,# Xinna Ma, Dong Lu, Heng Li, Yanping Zeng, Xiankun Tong, Limin Zeng, Jia Liu, Li Yang,* Jianping Zuo,* and Youhong Hu*, Discovery of Phthalazinone Derivatives as Novel Hepatitis B Virus Capsid Inhibitors, J. Med. Chem., 2020, 63(15): 8134-8145.
4.Zhicheng Xie#; Bing Wu #; Yingqiang Liu#; Wenming Ren; Linjiang Tong; Caigui Xiang; Aihuan Wei; Yuanzhuo Gao; Limin Zeng; Hua Xie*; Wei Tang*; Youhong Hu*; Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an o-Aminopyridyl Alkynyl Scaffold as Potential Treatment for Inflammatory Disorders, J. Med. Chem., 2020, 63 (3): 1397-1414.
5.Yu Lei#,Wenming Ren#, Cheng-Kun Wang, Rong-Rong Tao, Huai-Jiang Xiang, Li-Li Feng, Yin-Ping Gao, Quan Jiang, Xin Li*, Youhong Hu*, Feng Han*, Visualizing Autophagic Flux during Endothelial Injury with a Pathway-Inspired Tandem-Reaction Based Fluorogenic Probe, Theranostics 2019, Vol. 9, Issue 19, 5672-5680.
6.Yu-Fang Zhang, Wen-Di Duan, Jingjing Chen, and Youhong Hu*, Base-Promoted Cascade Reactions of 3(1-Alkynyl)chromones with Pyridinium Ylides to Chromeno[2,3-d]azepine Derivatives, J. Org. Chem., 2019, 84, 4467-4472.
7.Wenming Ren, Jingjing Zhang, Cheng Peng, Huaijiang Xiang, Jingjing Chen, Chengyuan Peng, Weiliang Zhu, Ruimin Huang,* Haiyan Zhang,* and Youhong Hu*, Fluorescent Imaging of β Amyloid Using BODIPY Based Near-Infrared Off On Fluorescent Probe, Bioconjugate Chem. 2018, 29, 3459-3466.
8.Xueli Yu, Gang Cheng, Lei Zhang, Yu Zhang, Qing Wang, Mengxue Zhao, Limin Zeng, Youhong Hu*, Linyin Feng*, N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination, Scientific Reports, 2018, 8,14040.
9.Dong Lu#, Jianan Liu#, Yunzhe Zhang#, Feifei Liu, Limin Zeng, Runze Peng, Li Yang, Huazhou Ying, Wei Tang, Wuhong Chen, Jianping Zuo, Xiankun Tong*, Tao Liu*, Youhong Hu*, Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors, European Journal of Medicinal Chemistry, 2018, Vol145, 328-337.
10.Dong Lu#, Juan Yan#, Lang Wang, Hongchun Liu, Limin Zeng, Minmin Zhang, Wenwen Duan, Yinchun Ji, Jingchen Cao, Meiyu Geng, Aijun Shen*, and Youhong Hu*, Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives, ACS Med. Chem. Lett., 2017, 8 (8), 830–834.
11.Shan Li, Penghui Wan, Jing Ai, Rong Sheng*, Yongzhou Hu*, and Youhong Hu*, Palladium-Catalyzed, Silver-Assisted Direct C-5–H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation, Adv. Synth. Catal., 2017, 359, 772 –778.
12.Dong Lu#, Feifei Liu#, Weiqiang Xing, Xiankun Tong, Lang Wang, Yajuan Wang, Limin Zeng, Chunlan Feng, Li Yang*, Jianping Zuo*, and Youhong Hu*, Optimization and Synthesis of Pyridazinone Derivatives as Novel Inhibitors of Hepatitis B Virus by Inducing Genome-free Capsid Formation, ACS Infect. Dis., 2017, 3 (3), 199–205.
13.Yang Liu#, Xia Peng#, Xiaocong Guan#, Dong Lu, Yong Xi, Shiyu Jin, Hui Chen, Limin Zeng, Jing Ai*, Meiyu Geng*, Youhong Hu*, Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors, Eur. J. Med. Chem., 2017, Vol. 126, 122-132.
14.Dong Lu#, Aijun Shen#, Yang Liu, Xia Peng, Weiqiang Xing, Jing Ai, Meiyu Geng*, Youhong Hu*, Design and synthesis of novel benzo[d]oxazol-2(3H)-one derivatives bearing 7-substituted-4-enthoxyquinoline moieties as c-Met kinase inhibitors, Eur. J. Med. Chem., 2016, Vol. 115, 191-200.
15.Yang Liu#, Shiyu Jin#, Xia Peng#, Dong Lu, Limin Zeng, Yiming Sun, Jing Ai*, Meiyu Geng*, Youhong Hu*, Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase, Eur. J. Med. Chem., 2016, Vol. 108, 322-333.
16.Ren Wenming#, Xu Mingming#, Liang Steven H., Xiang Huaijiang, Tang Li, Zhang Minkui, Ding Dejun, Li Xin, Zhang Haiyan*, Hu Youhong*, Discovery of a novel fluorescent probe for the sensitive detection of beta-amyloid deposits, Biosensors & Bioelectronics, 2016, 75, 136-141.
17.Xin Li#, Rong-Rong Tao#, Ling-Juan Hong, Juan Cheng, Quan Jiang, Ying-Mei Lu, Mei-Hua Liao, Wei-Feng Ye, Nan-Nan Lu, Feng Han*, Yong-Zhou Hu*, and You-Hong Hu*,Visualizing Peroxynitrite Fluxes in Endothelial Cells Reveals the Dynamic Progression of Brain Vascular Injury, J. Am. Chem. Soc. 2015, 137(38), 12296 12303.
18.Ya-Juan Wang, Dong Lu, Yi-Bin Xu, Wei-Qiang Xing, Xian-Kun Tong, Gui-Feng Wang, Chun-Lan Feng, Pei-Lan He, Li Yang*,Wei Tang*, You-Hong Hu*, Jian-Ping Zuo, A Novel Pyridazinone Derivative Inhibits Hepatitis B Virus Replication by Inducing Genome-Free Capsid Formation, Antimicrobial Agents and Chemotheraphy, 2015, 59(11):7061-72.
19.Weiqiang Xing#, Jing Ai#, Shiyu Jin#, Zhangxing Shi, Xia Peng, Lang Wang,Yinchun Ji, Dong Lu, Yang Liu, Meiyu Geng, Youhong Hu*, Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis, Eur. J. Med. Chem., 2015, 95, 302-312.
20.Yang Liu, Shiyu Jin, Liping Huang, and Youhong Hu*, Phase Transfer Reagent Promoted Tandem Ring-Opening and Ring-Closing Reactions of Unique 3-(1-Alkynyl) Chromones, Org. Lett., 2015, 17 (9), 2134–2137.
21.Shudong Duan#, Suling Huang#, Jian Gong, Yu Shen, Limin Zeng, Ying Feng, Wenming Ren, Ying Leng* and Youhong Hu*, Design and Synthesis of Novel Arctigenin Analogues for the Amelioration of Metabolic Disorders, ACS Med. Chem. Lett., 2015, 6 (4), 386-391.
22.Yang Liu, Shiyu Jin, Zi Wang, Linhua Song, and Youhong Hu*, Microwave Assisted Tandem Heck–Sonogashira Reactions of N,N-Di-Boc-Protected 6-Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3-d]Pyrimidines, Org. Lett., 2014, 16 (13), 3524–3527.
23.Jia Sheng, Bo Chao, Hong Chen, and Youhong Hu*, Synthesis of Chromeno[2,3-d]imidazol-9(1H)-ones via Tandem Reactions of 3-Iodochromones with Amidines Involving Copper-Catalyzed C–H Functionalization and C–O Bond Formation, Org. Lett., 2013, 15 (17), 4508–4511.
24.Weiqiang Xing#, Yan Fu#, Zhangxing Shi, Dong Lu, Haiyan Zhang*, Youhong Hu,* Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors, Eur. J. Med. Chem., 2013, 63, 95-103.
25.Ming Cheng, Jianwei Yan, Feng Hu, Hong Chen and Youhong Hu*，Palladium-catalyzed cascade reactions of 3-iodochromones with aryl iodides and norbornadiene leading to annulated xanthones，Chemical Science, 2013, 4 (1), 526 – 530.
26.Liping Huang, Yang Liu, Fuchun Xie, Youhong Hu*, An Organic Molecule Modulated Chemoselective Cyclization of Alkynyl Nitriles Tethered to 2-Alkyl Substituted Chromones with Multireactive Sites, Org. Lett., 2012, 14(24), 6122-6125.
27.Jianwei Yan, Ming Cheng, Feng Hu, and Youhong Hu*, Direct Synthesis of Functional Azaxanthones by Using a Domino Three-Component Reaction, Org. Lett., 2012, 14 (12), 3206–3209.
28.Bo Chao, Shijun Lin, Qingdong Ma, Dong Lu, and Youhong Hu*, Copper(I)-Mediated Cascade Reactions: An Efficient Approach to the Synthesis of Functionalized Benzofuro[3,2-d]pyrimidines, Org. Lett., 2012, 14 (9), 2398–2401.
29.Bo Chao, Xian-Kun Tong, Wei Tang, De-Wen Li, Pei-Lan He, Jean-Michel Garcia, Li-Min Zeng, An-Hui Gao, Li Yang, Jia Li, Fa-Jun Nan, Michael Jacobs, Ralf Altmeyer, Jian-Ping Zuo*, and You-Hong Hu*, Discovery and Optimization of 2,4-Diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors, J. Med.Chem., 2012, 55(7), 3135-3143.
30.Fuchun Xie#, Hongbing Zhao#, Dewen Li, Hong Chen, Haitian Quan, Xiaojing Shi, Liguang Lou*, and Youhong Hu*, Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors, J. Med. Chem. 2011, 54(9), 3200-3205.
31.Lizhi Zhao, Fuchun Xie, Gang Cheng, Youhong Hu*, A Base-Promoted Tandem Reaction of 3-(1-Alkynyl)chromones with 1,3-Dicarbonyl Compounds: An Efficient Approach to Functional Xanthones, Angew. Chem. Int. Ed., 2009, 48(35), 6520–6523.
32.Gang Cheng and Youhong Hu*, One-pot Synthesis of Furocoumarins through Cascade Addition-Cyclization-Oxidation, Chem. Comm., 2007, 31, 3285-3287.
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