Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

YANG Weibo, Ph.D., Principal investigator of Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Dr. Yang received MSc from Dalian University of Science and Technology in 2010 and his Ph.D in chemistry from University of Heidelberg in 2013. After he obtained his PhD under the supervision of Prof. Stephen Hashmi in 2013, he joined the laboratory of Prof. Jin-Quan Yu at the Scripps Research Institute as a research associate. In 2015, he joined Prof. Peter G Schultz as a research associate. Since Oct. 2016, Dr. Yang has worked at Shanghai Institute of Materia Medica, Chinese Academy of Sciences. His current research interest is mainly focused on the studying on the transition-metal-catalyzed rearrangement, domino as well as C–H activation reactions and their applications in medicinal chemistry.

EDUCATION

2015.12–2016.10: Associate Researcher, The Scripps Research Institute, CA, USA; with Prof. Peter G Schultz.

2013.12–2015.12: Associate Researcher, The Scripps Research Institute, CA, USA; with Prof. Dr. Jin-quan Yu.

2013.9–2013.11: Research Assistant, Heidelberg University, Germany; with Prof. Dr. Stephen Hashmi.

2010.9–2013.8: Ph. D., Heidelberg University, Germany; guided by Prof. Dr. Stephen Hashmi.

2007.9–2010.7: M. S., Dalian University of Technology, Dalian, China; guided by Prof. Chun Liu.

WORK EXPERIENCE

Oct 2016–Present Professor in Shanghai Institute of Materia Medica, CAS.

Research Directions

Metal catalysis, C-H activation, mechanistic research on organic reactions, Natural product-inspired Macrocyclic compounds synthesis, Protein-Protein interaction inhibitors design

Grants & Research Projects

2013-2015 TSRI-Vertex Pharmaceuticals
2015-2016 TSRI-Calibr Pharmaceuticals

Achievements

1) A highly efficient protocol for the Pd(OAc)2-catalyzed aerobic Suzuki reaction of aryl chlorides is reported, which is proposed to be promoted by the N,O-bidentate ligand formed in situ via the hydrogen bond of solvents

2) Benzofurans,3,4-disubstituted pyrrolidin-2-one as well as ynoes were achieved by using gold-catalyzed rearrangement,cyclization strategies.

3) Ttriple C-H activation reaction provides a short route for the synthesis of medicinally important benzo[e]indazole derivatives.

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Social Titles

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Awards & Honors

Liaoning outstanding graduates 2010

CSC Fellowship

Evonic Degussa Award

Thieme Chemistry Journal Award 2017

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Pubilcations

Full Publication List

Selected Publications

1. Jiping Hao,+ Xueying Guo,+ Shijun He,+ Zhongliang Xu, Lu Chen, Zhongyu Li, Bichao Song Jianping Zuo,Zhenyang Lin,* and Weibo Yang*, Marine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp3)-H olefination mediated by donor/donor carbenes. Nat. Commun. 2021, 12, 1304.

2. Wei Shi+, Feng Tang+, Jiwei Ao, Qun Yu, Junjie Liu, Yubo Tang, Bofeng Jiang, Xuelian Ren, He Huang, Weibo Yang,* and Wei Huang*, Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis. Angew. Chem. Int. Ed. 2020, 59, 19940-19944.

3. Bichao Song, Peipei Xie, Yingzi Li, Jiping Hao, Lu Wang, Xiangyang Chen, Zhongliang Xu, Haitian, Quan, Liguang, Lou, Yuanzhi Xia,* K. N. Houk,* and Weibo Yang*, Pd-Catalyzed Decarboxylative Olefination: Stereoselective Synthesis of Polysubstituted Butadienes and Bioactive Macrocyclic Inhibitors. J. Am. Chem. Soc. 2020, 142, 9982-9992

4. Lu Chen, Haitian Quan, Zhongliang Xu, Hao Wang, Yuanzhi Xia, Liguang Lou,* Weibo Yang,* A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation. Nat. Commun. 2020, 11, 2151.

5. Yi Xu, Lu Chen, Yu-wen Yang, Zhiqiang Zhang, Weibo Yang*, Vinylethylene Carbonates as α,β-Unsaturated Aldehyde Surrogates for Regioselective [3 + 3] Cycloaddition. Org. Lett., 2019, 21, 6674-6678

6. Jiping Hao, Yi Xu, Zhongliang Xu, Zhiqiang Zhang, Weibo Yang*, Pd-Catalyzed Three-Component Domino Reaction of Vinyl Benzoxazinanones for Regioselective and Stereoselective Synthesis of Allylic Sulfone-Containing Amino Acid Derivatives. Org. Lett., 2018, 20, 7888-7892

7. Yuwen Yang, Weibo Yang*, Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates. Chem. Commun., 2018, 24, 12182-12185

8. Lei Deng, Arjan W. Kleij,* Weibo Yang*, Diversity‐Orientated Stereoselective Synthesis through Pd‐Catalyzed Switchable Decarboxylative C-N/C-S Bond Formation in Allylic Surrogates. Chem. Eur. J., 2018, 24, 19156-19161

9. Weibo Yang, Shengqing Ye, YvonneSchmidt, Dean Stamos,* Jin-QuanYu*: Ligand-Promoted C(sp3)-H Olefination en Route to Multi-functionalized Pyrazoles. Chem. Eur. J. 2016, 22, 7059-7062.

10. Shengqing Ye, Weibo Yang, Timothy Coon, Dewey Fanning, Tim Neubert, Dean Stamos, Jin-Quan Yu*: Heterocyclic Carbene Ligand-Enabled C(sp3 )-H Arylation of Piperidine and Tetrahydropyran Derivatives. Chem. Eur. J. 2016, 22, 4748-4752.

11. Weibo Yang, Shengqing Ye, Dewey Fanning, Timothy Coon, Yvonne Schmidt, Paul Krenitsky, Dean Stamos* and Jin-Quan Yu*: Orchestrated Triple C–H Activation Reactions Using Two Directing Groups: Rapid Assembly of Complex Pyrazoles. Angew. Chem. Int. Ed. 2015, 54, 2501-2504.

12. Weibo Yang, A. Stephen K. Hashmi*: Mechanistic insights of the gold chemistry of allenes. Chem. Soc. Rev. 2014, 43, 2941–2955

13. Yang Yu+, Weibo Yang+, Daniel Pfl？sterer, A. Stephen K. Hashmi*: Dehydrogenative Meyer-Schuster-like Rearrangement: A Gold-Catalyzed Reaction Generating an Alkyne. Angew. Chem. Int. Ed. 2014, 53, 1144-1147. (Y. Yu and W. Yang contributed equally to this work)

14. Yang Yu+, Weibo Yang+, Frank Rominger, A. Stephen K. Hashmi*: In Situ Generation of Nucleophilic Allenes by the Gold-Catalyzed Rearrangement of Propargylic Esters for the Highly Diastereoselective Formation of Intermolecular C(sp3)-C(sp2) Bonds.Angew. Chem. Int. Ed. 2013, 52, 7586-7589. (Y. Yu and W. Yang contributed equally to this work)

15. A. Stephen K. Hashmi*, Weibo Yang, Yang Yu, M. Hansmann, Matthias Rudolph, Frank Rominger: Gold-Catalyzed Formal 1,6-Acyloxy Migration Leading to 3,4-Disubstituted Pyrrolidin-2-ones. Angew. Chem. Int. Ed. 2013, 52, 1329-1332. (Highlighted in Synfacts)

16. A. Stephen K. Hashmi*, Weibo Yang, Frank Rominger: Gold(I)-Catalyzed Formation of Benzo[b]furans from 3-Silyloxy-1,5-enynes. Angew. Chem. Int. Ed. 2011, 50, 5762-5765.

17. Weibo Yang, Long Huang, Yang Yu, Daniel Pflasterer, Frank Rominger, A. Stephen K. Hashmi*:Highly Diasteroselective and Regioselective Copper-Catalyzed Acylnitroso Dearomatization Reaction under Aerobic Oxidation Conditions. Chem. Eur. J. 2014, 20, 3927-3931

18. Weibo Yang, Tao Wang, Yang Yu, Shuai Shi, Tuo Zhang, A. Stephen K. Hashmi*: Nitrones as Trapping Reagents of α,β-Unsaturated Carbene Intermediates – [1,2]Oxazino[5,4-b]indoles by a Platinum-Catalyzed Intermolecular [3+3] Cycloaddition. Adv. Synth. Catal. 2013, 355, 1523-1528. (Highlighted in Synfacts)

19. Weibo Yang, Yang Yu, Tuo Zhang, Max M. Hansmann, Daniel Pfl?sterer, A. Stephen K. Hashmi*: Gold-Catalyzed Highly Diastereoselective Synthesis of Functionalized 3,4-Disubstituted Butyrolactams via Phosphatyloxy or Carbonate Double Migrations. Adv. Synth. Catal. 2013, 355, 2037-2043. (Highlighted in Synfacts)

20. A. Stephen K. Hashmi*, Weibo Yang, Frank Rominger: Gold-Catalysis: Highly Efficient and Regio-Selective Carbonyl Migration in Alkynyl-Substituted Indole-3-Carboxamides Leading to Azepino[3,4-b]indol-1-ones. Adv, Synth, Catal. 2012, 354, 1273-1279. (Highlighted in Synfacts)

21. A. Stephen K. Hashmi*, Weibo Yang, Frank Rominger: Gold-Catalysis: Gold(I)-Catalyzed Rearrangement of 3-Silyloxy-1,5-enynes: An Efficient Synthesis of Benzo[b]thiophenes, Dibenzothiophenes, Dibenzofurans, and Indole Derivatives. Chem. Eur. J.2012, 18, 6576-6580.

22. Weibo Yang, Liu Chun*, Jieshan Qiu: In Situ Formation of N,O-Bidentate Ligand via the Hydrogen Bond for Highly Efficient Suzuki Reaction of Aryl Chlorides. Chem. Commun. 2010, 2659-2661. (Highlighted in Synfacts)

23. Liu Chun*, Weibo Yang: A fast and oxygen-promoted protocol for the ligand-free Suzuki reaction of 2-halogenated pyridines in aqueous media. Chem. Commun. 2009, 6267-6269.

24. A. Stephen K. Hashmi*, Tobias Haffner, Weibo Yang, Sreekumar Pankajakshan, Sascha Schafer, Lara Schultes, Frank Rominger, Wolfgang Frey: Gold Catalysis: Non-Spirocyclic Intermediates in the Conversion of Furanynes by the Formal Insertion of an Alkyne into an Aryl–Alkyl C–C Single Bond. Chem. Eur. J. 2012, 18, 10480-10486.

25. Shuai Shi, Tao Wang, Weibo Yang, Matthias Rudolph, A. Stephen K. Hashmi*: Gold Catalyzed Synthesis of Glyoxals via Oxidation of Terminal Alkynes; One-Pot Synthesis of Quinoxalines. Chem. Eur. J. 2013, 19, 6576-6580.

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