ZHOU Zikai
Principal Investigator
Biotech Drug Research Center;Zhongshan Branch of Drug Discovery & Development Institute
Personal Homepage
CONTACT
zhouzikai@simm.ac.cn
201203
555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China
Biography
Education:
2004.09 - 2010.11, University of Toronto, The Hospital for Sick Children, Ph.D.
2002.09 - 2004.03, Manchester University, M.Sc.
1998.09 - 2002.07, Nanjing University, B.Sc.
Work Experience:
2020.08 - Present Shanghai Institute of Materia Medica, CAS; Professor
2018.04 - 2020.07 Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center; Professor
2011.01 - 2018.03 Southeast University, Associate Professor
Research Directions
1. Immunoneuropsychiatry
2. Development of immune cell therapy for CNS disorders
Grants & Research Projects
Achievements
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Social Titles
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Awards & Honors
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Pubilcations
Full Publication List
Selected Publications
1. Zhou Z#, Liu A#, Xia S#, Leung C#, Qi J, Meng Y, Xie W, Park P, Collingridge G*, and Jia Z*. The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning. Nature Neuroscience. 2018 Jan;21(1):50-62.
2. Wang Y#, Zeng C#, Li J#, Zhou Z, Ju X, Xia S, Li Y, Liu A, Teng H, Zhang K, Shi L, Bi C, Xie W, He X, Jia Z, Jiang Y, Cai T, Wu J, Xia K*, Sun ZS*. PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior. Cell Rep. 2018 Aug 21;24(8):2029-2041.
3. Yang X#, He G#, Zhang X, Chen L, Kong Y, Xie W, Jia Z, Liu WT*, Zhou Z*. Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain. Neuropharmacology. 2017 Oct;125:284-294.
4. He G#, Yang X#, Wang G, Qi J, Mao R, Wu Z, Zhou Z*. Cdk7 is required for activity-dependent neuronal gene expression, long-lasting synaptic plasticity and long-term memory. Frontiers in Molecular Neuroscience. 2017 Nov 7;10:365.
5. Xia S#, Zhou Z#, Leung C, Zhu Y, Pan X, Qi J, Morena M, Hill MN*, Xie W*, Jia Z*. p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus. eLlife. 2016 Jun 14;5.
6. Liu A#, Zhou Z#, Dang R, Zhu Y, Qi J, He G, Leung C, Pak D, Jia Z*, Xie W*. Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization, Journal of Cell Biology. 2016 Feb 15; 212(4):449-63. (COVER STORY with COMMENTARY)
7. Li Y#, Zhou Z#, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W*, Han J*. Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. The Journal of Neuroscience. 2013, 33(39):15545-54
8. Zhou Z, Hu J, Passafaro M, Xie W, Jia Z*. GluA2 (GluA2) regulates metabotropic glutamate receptor-dependent long-term depression through N-cadherin-dependent and cofilin-mediated actin reorganization. The Journal of Neuroscience. 2011, 31(3), 819-833,
9. Huang W#, Zhou Z#, Asrar S, Henkelman M, Xie W, Jia Z*. p21-activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties. Molecular and Cellular Biology. 2011 31(3), 388-403, (with COMMENTARY)
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