Biography
Dr. Zhu was graduated with his PhD degree from Shanghai Institute of Organic Chemistry (SIOC) (2009-2014) under the supervision of Prof. Biao Yu and received his postdoctoral from the University of Colorado at Boulder (2015-2016) with Prof. Xiang Wang and University of Georgia with Prof. Geert-Jan Boons. During 2019-2022, Dr Zhu start his independent research work at Yunnan University in China, afte which he moved to SIMM as a principal investigator.
Education：
2009.09 - 2014.07 Ph.D. Orgnic chemistry, Shanghai Institute of Organic Chemistry, CAS, China
2005.09-2009.07 B.S. Pharmacy, China Pharmaceutical Univeresity, Nanjing, China
Work Experience：
2022.04-current Professor, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
2019.04-2022.04 associate professor, Yunnan University, Kunming, China
2016.12-2019.02 postdoc, University of Georgia, Athens, USA
2009.03-2016.12 postdoc, University of Colorado at Boulder, Boulder, USA
Research Directions
1. Chemical synthesis of bioactive and complex glycoside and glycans
2. Development of novel and efficient methodology to access glycans
3. Structure bioactivity relationship studies on the bioactive carbohydrate-based compound
Grants & Research Projects
National Natural Science Foundation of China (22007080)
Achievements
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Social Titles
1. Development of efficient methogology for the construction of complex α-glycosyl phosphosaccharides (Nature Communications. 2022, 13,421)
2. Total synthesis of bioactive natural product acteoside (Org. Lett. 2021, 23, 9210-9215)
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Awards & Honors
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Pubilcations
Full Publication List
Selected Publications
1. Zhang, X.; Yang, Y.; Ding, J.; Zhao, Y.; Zhang, H.; Zhu, Y.* Stereoselective Gold(I)-Catalyzed Approach to the Synthesis of Complex α-Glycosyl Phosphosaccharides. Nat. Commun. 2022, 13, 421.
2. Zhang, X.;# Yang, Y.;# Wang, F.;# Zhou, Z.; Zhang, H.*; Zhu, Y.* An Approach to the Synthesis of Electron-Rich and Hindered Esters and Its Application to the Synthesis of Acteoside. Org. Lett. 2021, 23, 9210-9215.
3. Zhu, Y.;# He, W.;# Wang, W.; Pitsch, C.; Wang, X.; Wang, X.* Enantioselective Tandem Cyclization of Alkyne-Tethered Indoles Using Cooperative Silver(I)/Chiral Phosphoric Acid Catalysis. Angew. Chem. Int. Ed. 2017, 56, 12206-12209.
4. Zhu, Y.; Yu, B.* Characterization of the Isochromen-4-yl-gold(I) Intermediate in the Gold(I)-Catalyzed Glycosidation of Glycosyl ortho-Alkynylbenzoates and Enhancement of the Catalytic Efficiency Thereof. Angew. Chem. Int. Ed. 2011, 50, 8329-8332.
5. Zhu, Y.;# Cleaver, L.;# Wang, W.; Podoll, J.; Walls, S.; Jolly, A.; Wang, X.* Tetracyclic indolines as a novel class of b-lactam-selective resistance-modifying agent for MRSA. Eur. J. Med. Chem. 2017, 125, 130-142.
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