Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

Dr. ZHANG Naixia graduated from Beijing Medical University in 1998, and got a Bachelor degree with the major in medicinal chemistry. In the same year Dr. ZHANG got admitted into the PhD training program at Shanghai Institute of Organic Chemistry, and got the PhD degree in 2003. In May of 2004, Dr. ZHANG joined Dr. Kylie Walters’ lab in the Department of Biochemistry, Molecular Biology, and Biophysics at the University of Minnesota as a postdoctoral fellow, and was then promoted to research assistant professor in 2008. In October of 2010, Dr. ZHANG Naixia joined Shanghai Institute of Materia Medica, Chinese Academy of Sciences as a principal investigator. Dr. ZHANG’s major research interests focus on NMR studies of protein-ligand (protein, DNA, small molecule etc.) interactions, and have got excellent achievements in quite a few of research projects. Up to date, Dr. ZHANG Naixia has published more than 60 research articles with a total citation exceeding 1300 times.

EDUCATION

09/01/1994-07/31/1998, B.S., Medicinal Chemistry, Beijing Medical University, Beijing, China

09/01/1998-07/31/2003, Ph.D., Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

WORK EXPERIENCE

05/2004-06/2008, Postdoctoral Fellow, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA

06/2008-02/2010, Research Assistant Professor, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA

10/2010-up to date, Research Professor & Principal Investigator, Department of Analytical Chemistry, Shanghai Institute of Meteria Medica, Chinese Academy of Sciences, Shanghai, China

Research Directions

1.NMR studies of protein-protein interactions (research targets: cancer-related key players of protein quality control system);

2.NMR studies of drug target (protein)-small molecule interactions;

3.Pharmacology and pharmacotoxicology studies by using NMR-based metabolomics techniques.

Grants & Research Projects

1.National Natural Science Foundation of China, Discovery of novel type of anti-cancer inhibitors targeting USP28 catalytic domain and their working mechanism elucidation, Project leader, 2020.01-2023.12

2.National Natural Science Foundation of China, Discovery of novel anti-cancer inhibitors targeting Hsp90 middle domain and their working mechanism elucidation, Project leader, 2018.01-2021.12

3.National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program” of China, Participant, 2018.01-2020.12

4.Major State Basic Research Development Program of China, Posttranslational modifications of lysine residues and protein function, Participant, 2013.01-2017.12

5.National Natural Science Foundation of China, ATP-dependent conformational changes of Hsp90 and Drug Discovery, Project leader, 2013.01-2016.12

6.Chinese Academy of Sciences, NMR research platform for fragment-based drug discovery, Project leader, 2011.10-2013.10

Achievements

1.Molecular mechanism studies of substrate capture process of ubiquitin-proteasome protein degradation pathway;

2.Studies of molecular regulating mechanisms for function display of deubiquitinases USP28/USP25 and drug discovery;

3.Studies of molecular regulating mechanisms for function display of Hsp90 and drug discovery;

4.Intrinsically disordered protein-active compound interaction study;

5.NMR research platform for fragment-based drug discovery;

6.Metabolomics-based pharmacology and pharmocotoxicology research platform.

morefold

Social Titles

Committee Member of Biological Magnetic Resonance Academic Subgroup, Biophysical Society of China;

Editorial Board Member of Scientific Reports and Magnetic Resonance Letters.

morefold

Awards & Honors

2006, Scholar-in-Training Award, Ubiquitin Conference (Ubiquitin and Cancer: From Molecular Targets and Mechanisms to the Clinic), American Association for Cancer Research

2008, Paul D. Boyer-James B. Peter Award, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota

morefold

Pubilcations

Full Publication List

Selected Publications

1.Zhou, C.#, Zhang, C.#, Zhu, H.#, Liu, Z., Su, H., Zhang, X., Chen, T., Zhong, Y., Hu, H., Xiong, M., Zhou, H., Xu, Y.*, Zhang, A.*, Zhang, N.*, Allosteric Regulation of Hsp90α's Activity by Small Molecules Targeting the Middle Domain of the Chaperone, iScience, 23(2), 100857, 2020.

2.Xiao, R.#, Ding, C.#, Zhu, H., Liu, X., Gao, J., Liu, Q., Lu, D., Zhang, N.*, Zhang, A.*, Zhou, H.*, Suppression of Asparagine Synthetase Enhances the Antitumor Potency of ART and Artemalogue SOMCL-14-221 in Non-Small Cell Lung Cancer, Cancer Letters, 475, 22-33, 2020

3.Yang, Y., Ding, Y., Zhou, C., Wen, Y., Zhang, N.*, Structural and Functional Studies of USP20 ZnF-UBP Domain by NMR, Protein Science, 28(9), 1606-1619, 2019

4.Liu, X.#, Wang, W.#, Chen, H., Zhang, H.*, Zhang, N.*, Interplay Between Alzheimer's Disease and Global Glucose Metabolism Revealed by the Metabolic Profile Alterations of Pancreatic Tissue and Serum in APP/PS1 Transgenic Mice, Acta Pharmacologica Sinica, 40(10), 1259-1268, 2019

5.Chen, D.#, Chen, Y.#, Lian, F.#, Chen, L., Li, Y., Cao, D., Wang, X., Chen, L., Li, J., Meng, T., Huang, M.*, Geng, M., Shen, J., Zhang, N.*, Xiong, B.*, Fragment-based Drug Discovery of Triazole Inhibitors to Block PDEδ-RAS Protein-Protein Interaction, European Journal of Medicinal Chemistry, 163, 597-609, 2019

6.Hou, X.#, Wang, M.#, Wen, Y.#, Ni, T., Guan, X., Lan, L., Zhang, N.*, Zhang, A.*, Yang, C.*, Quinone skeleton as a new class of irreversible inhibitors against Staphylococcus aureus sortase A, Bioorganic & Medicinal Chemistry Letters, 28(10), 1864-1869, 2018

7.Yang, Y.#, Shi, L.#, Ding, Y., Shi, Y., Hu, H., Wen, Y.*, Zhang, N.*, Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25, Biophysical Journal, 112(10), 2099-2108, 2017

8.Yu, J.#, Chen, T.#, Zhou, C.#, Lian, F., Tang, X., Wen, Y., Shen, J., Xu, Y., Xiong, B.*, Zhang, N.*, NMR-based Platform for Fragment-Based Lead Discovery Used in Screening BRD4-targeted Compounds, Acta Pharmacologica Sinica, 37(7), 984-93, 2016

9.Zhang, T.#, Wang, W.#, Huang, J., Liu, X.*, Zhang, H.*, Zhang, N.*, Metabolomic Investigation of Regional Brain Tissue Dysfunctions Induced by Global Cerebral Ischemia, BMC Neuroscience, 17(1), 25, 2016

10.Ma, H.#, Liu, X.#, Wu, Y.*, Zhang, N.*, The Intervention Effects of Acupuncture on Fatigue Induced by Exhaustive Physical Exercises: A Metabolomics Investigation, Evidence-based Complementary and Alternative Medicine, 2015, 508302, 2015

11.Zhang, H.#, Zhou, C.#, Chen, W., Xu, Y., Shi, Y., Wen, Y.*, Zhang, N.*, A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain, Scientific Reports, 5, 9542, 2015

12.Wen, Y.#, Shi, L.#, Ding, Y., Cui, R., He, W.T., Hu, H.*, Zhang, N.*, The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights, Biochemical Journal, 471(2), 155-65, 2015

13.Zhang, N.#, Wang, Q.#, Ehlinger, A.#, Randles, L.#, Lary, J.W., Kang, Y., Haririnia, A., Storaska, A.J., Cole, J.L., Fushman, D., Walters, K.J.*, Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13, Molecular Cell, 35(3), 280-290, 2009

14.Husnjak, K.#, Elsasser, S.#, Zhang, N.#, Chen, X., Randles, L., Shi, Y., Hofmann, K., Walters, K.J.*, Finley, D.*, Dikic, I.*, Proteasome subunit Rpn13 is a novel ubiquitin receptor, Nature, 453(7194), 481-488, 2008

morefold