Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

Dr. WU Wanying is a professor and doctoral supervisor of Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China. She took postgraduate training at Beijing University of Chinese Medicineand received the Ph.D. degree in 2002. After a postdoctoral fellowship at the School of Pharmaceutical Sciences, Peking University, she joined the Shanghai Institute of Materia Medica and was later promoted to associate professor and professor. Dr. Wu joined the United States Pharmacopeia (USP) as a visiting Scientist in 2013 and took part in the establishment of the Herbal medicine Compendium. Dr. Wu’ current research interests are mainly in systematic analysis of TCM complex system. She has conducted eleven projects as PI and participated in more than 20 projects as a co-investigator including those from National S&T Major Special Project, The Ministry of Science and Technology International Cooperation, and National Natural Science Foundation. She has published 114 papers in renowned international and national journals including J Chromatogr A., Anal Chim Acta., Anal Bioanal Chem.etc, and she is the editor of six academic monographs. In addition, she has applied for 19 items of domestic invention patents. Among them, 14 items had been authorized. As a major performer, She has established 32 TCM standards that have been accepted by U.S. Pharmacopeia or European Pharmacopoeia. Another major finding is that She developed an innovative TCM prescription named “Dan Qi Tong Mai Tablet” that had been approved by SFDA for clinical trial in 2009 in China. She won several awards including the Second Prize for The State Natural Science in 2012 (The third one), the First Prize for Science and technology of China Association of Chinese Medicine in 2015 (The Second one), the Second Prize for The National Science and Technology Progress in 2016 (The third one), the March-Eighth Red-Banner Pacesetter of Shanghai science and technology system in 2013, and the March-Eighth Red-Banner Pacesetter of Shanghai in 2017.

EDUCATION
1999/09 – 2002/07，Beijing University of Chinese Medicine，Ph.D
1996/09 – 1999/07，Heilongjiang University Of Chinese Medicine，M.S.
1992/09 – 1996/07，Heilongjiang University Of Chinese Medicine，B.S.

WORK EXPERIENCE
2011/10 – Present，Shanghai Institute of Materia Medica, Chinese Academy of Sciences， Professor, Principal Investigator
2006/09– 2011/09，Shanghai Institute of Materia Medica, Chinese Academy of Sciences，Associate Professor
2005/06– 2006/08，Shanghai Institute of Materia Medica, Chinese Academy of Sciences，Assistant Professor
2002/09 – 2005/05，Beijing University Health Science Center，Post-Doctor

Research Directions

R&D of new drugs for modern TCM and quality control of TCM

Grants & Research Projects

1. National Natural Science Foundation Project，81673591，2017/01-2020/12，PI
2. National Project for Standardization of Chinese Materia Medica，ZYBZH-C-HEB-12，2016/01-2018/12，PI
3. National Project for Standardization of Chinese Materia Medica，ZYBZH-Y-SC-40， 2016/01-2018/12，PI
4. Shanghai Scientific Research Project，15DZ0502800，2015/06-2018/06，PI
5. National Natural Science Foundation Project，81473344，2015/01-2018/12，PI
6. "863" National Project，SS2013AA090302，2013/01-2015/12, PI.
7. National Natural Science Foundation Project，81073026，2011/01-2013/12，PI
8. National S&T Major Special Project,，2009ZX09102-122，2009/01-2011/12，PI
9. International Cooperation Ministry of Science Project，2008DFA30350，2007/10-2011/10，PI
10. Shanghai Scientific Research Project，07DZ19711，2007/10-2011/09，PI
11. Frontier Project of Young Talents in the Knowledge Innovation Project of the Chinese Academy of Sciences，07G602B024，2007/01-2009/12，PI

Achievements

Dr. Wu have published 114 papers in renowned international and national journals including J Chromatogr A., Anal Chim Acta., Anal Bioanal Chem.etc, and she is the editor of six academic monographs. In addition, she have applied for 19 items of domestic invention patents. Among them, 14 items had been authorized. As a major performer, She have established 32 TCM standards that has been accepted by U.S. Pharmacopeia or European Pharmacopoeia. Another major finding is that She developed an innovative TCM prescription named “Dan Qi Tong Mai Tablet” that had been approved by SFDA for clinical trial in 2009 in China.

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Social Titles

Member of the 11th National Pharmacopoeia Commission.
Member of the USP Herbal Medicines Compendium-East Asia Expert Panel.
Council Member and Secretary General of Specialty Committee of TCM Pharmaceutical Analysis of World Federation of Chinese Medicine Societies.
Editorial Board Member of Phytomedicine.
Editorial Board Member of Chinese Herbal Medicines.
Executive Director of Drug Quality and Process Control Branch of China Instrument and Control Society.

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Awards & Honors

Award of the Second Prize for The State Natural Science in 2012 (The third one).
Award of the First Prize for Science and technology of China Association of Chinese Medicine in 2015 (The Second one).
Award of the Second Prize for The National Science and Technology Progress in 2016 (The third one).
Award of March-Eighth Red-Banner Pacesetter of Shanghai science and technology system in 2013.
Award of March-Eighth Red-Banner Pacesetter of Shanghai in 2017.

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Pubilcations

Full Publication List

Selected Publications

1. Huiqin Pan#, Wenzhi Yang#, Changliang Yao, Yao Shen, Yibei Zhang, Xiaojian Shi, Shuai Yao, Wanying Wu*, Dean Guo*. Mass defect filtering-oriented classification and precursor ions list-triggered high-resolution mass spectrometry analysis for the discovery of indole alkaloids from Uncaria sinensis, J Chromatogr A., 2017, 1516: 102–113.
2. Changliang Yao#, Wenzhi Yang#, Wen Si, Yao Shen, Naixia Zhang, Huali Chen, Huiqin Pan, Min Yang, Wanying Wu*, Dean Guo*. An enhanced targeted identification strategy for the selectiveidentification of flavonoid O-glycosides from Carthamus tinctorius byintegrating offline two-dimensional liquid chromatography/linearion-trap-Orbitrap mass spectrometry, high-resolution diagnosticproduct ions/neutral loss filtering and liquid chromatography-solidphase extraction-nuclear magnetic resonance, J Chromatogr A., 2017, 1491: 87-97.
3. Xiaojian Shi#, Wenzhi Yang#, Shi Qiu, Changliang Yao, Yao Shen, Qirui Bi, Min Yang, Wanying Wu*, Dean Guo*. An in-source multiple collision-neutral loss filtering based nontargeted metabolomics approach for comprehensive analysis of malonyl-ginsenosides from Panax ginseng, P. quinquefolius, and P. notoginseng, Anal Chim Acta., 2017, 952: 59-70.
4. Qirui Bi#, JinjunHou#, PengQi#, ChunhuaMa, Ruihong Feng, Bingpeng Yan, Jianwei Wang, Xiaojian Shi, Yuanyuan Zheng, Wanying Wu*, Dean Guo*, TXNIP/TRX/NF-κB and MAPK/NF-κB pathways involved in the cardiotoxicity induced by Venenum Bufonis in rats, Sci Rep., 2016, 6: 22759.
5. Shi Qiu#, Wen-zhi Yang#, Chang-liang Yao, Zhi-dong Qiu, Xiao-jian Shi, Jing-xian Zhang, Jin-jun Hou, Qiu-rong Wang, Wanying Wu*, Dean Guo*, Nontargeted metabolomic analysis and "commercial-homophyletic" comparison-induced biomarkers verification for the systematic chemical differentiation of five different parts of Panax ginseng, J Chromatogr A, 2016, 1453: 78-87.
6. Shi Qiu#, Wenzhi Yang#, Xiaojian Shi, Changliang Yao, Min Yang, Xuan Liu, Baohong Jiang, Wanying Wu*, Dean Guo*, A green protocol for efficient discovery of novel natural compounds: Characterization of new ginsenosides from the stems and leaves of Panax ginseng as a case study, Anal Chim Acta., 2015, 93: 65-76.
7. Ruihong Feng#, Jinjun Hou#, Yibei Zhang, Huiqin Pan, Wenzhi Yang, Peng Qi, Shuai Yao, Luying Cai, Min Yang, Baohong Jiang, Xuan Liu, Wanying Wu*, Dean Guo*, An efficient and target-oriented sample enrichment method for preparative separation of minor alkaloids by pH-zone-refining counter-current chromatography, J Chromatogr A, 2015, 1409: 159-165.
8. Changliang Yao#, Wenzhi Yang#, Wanying Wu*, Juan Da, Jinjun Hou,Jingxian Zhang, Yanhai Zhang, Yan Jin, Min Yang, Baohong Jiang, Xuan Liu, Dean Guo*, Simultaneous quantitation of five Panax notoginseng saponins by multi heart-cutting two-dimensional liquid chromatography: Method development and application to the quality control of eight Notoginseng containing Chinese patent medicines, J Chromatogr A, 2015, 1402: 71-81.
9. Juan Da, Wanying Wu*, Jinjun Hou, Huali Long, Shuai Yao, Zhou Yang, Luying Cai, Min Yang, Baohong Jiang, Xuan Liu, Chunru Cheng, Yifeng Li, Dean Guo*, Comparison of two officinal Chinese pharmacopoeia species of Ganoderma based on chemical research with multiple chromatographic and spectrographic technologies and chemometics analysis, J Chromatogr A, 2012, 1222: 59-70.
10. Jinjun Hou, Wanying Wu*, Juan Da, Shuai Yao, Huali Long, Zhou Yang, Luying Cai, Min Yang, Xuan Liu, Baohong Jiang, Dean Guo*, Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard, J Chromatogr A, 2011, 1218: 5618-5627.

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