ZHANG Jiwen
Principal Investigator
Pharmaceutical Preparation Research Center
Personal Homepage
CONTACT
jwzhang@simm.ac.cn
+86-21-68077837
201203
501# Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China.
Biography
Prof. Dr. ZHANG Jiwen, now serves as the principal investigator in Shanghai institute of Materia Medica (SIMM), Chinese Academy of Science. He has carried out the interdisciplinary research by establishing cooperation with research team at home and abroad. His team utilized primarily the synchrotron to establish quantitative methods for characterizing the irregular and dynamic structure of DDS, and started a new area as Structure Pharmaceutics, focusing on the 3D structure of pharmaceutical dosage forms and particulate systems or excipients. His team is also specialized in supramolecular systems made of cyclodextrins, like CD-MOFs and derivative materials, for controlled release and target drug delivery systems. Aiming at the evaluation of DDS, he has established the pharmacokinetics theory for the sustained and controlled-release systems, putting forward the quantitative method for optimizing the formulation of the sustained and controlled-release systems, and has designed new formulation such as biomimetic DDS. DPI, osmotic pump systems and nano-particulate systems are the top dosage forms to this team.
Education
1997-2001, School of Pharmacy, Shenyang Pharmaceutical University, Pharmaceutics, Ph.D.
1990–1993, School of Pharmacy, China Pharmaceutical University, Pharmaceutics, M.S.
1986-1990, School of Pharmacy, Shenyang Pharmaceutical University, Pharmaceutical engineering, B.S.
1981-1984, Anqing Health School, Assistant Pharmacist
Work Experience
20xx- present, Executive Vice Director, Yangtze Delta Drug Advanced Research Institute
2019- present, Deputy Director, NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients
2007.06-present, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Professor and Principal Investigator
2005.01-2014.06, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Vice director and director for the Department of Scientific Research, secretary of the academic committee, chairman of IACUC, director of the office for the major drug innovation project management, special assistant of the director-general of the institute
2003.08-2005.01, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, postdoctoral fellow
1995.07-2003.08, New Drug Research Institute in Anhui, director
1994.06-1995.07, Hangzhou Jiuyuan Gene Engineering Co., Ltd., Manager for Manufacturing Department
1993.07-1994.06, Luoyang Pharmaceutical Factory, Assistant of the chief Engineer
1984.06-1986.09, Anhui Provincial TB Institute, Assistant Pharmacist
Research Directions
1.Structure Pharmaceutics;
2.Pharmacokinetics for controlled/sustained drug delivery systems;
3.Supramolecular drug delivery systems.
Grants & Research Projects
1.National Key R&D Program of China, Joint research on quality research and evaluation technology of drug preparations for treatment of major diseases, 2020.06-2023.05
2.National Natural Science Foundation of China, Theoretical research on structure pharmaceutics: quantitative structure of pharmaceutical preparations and its control on drug release, 2018.01-2021.12
Achievements
1. Pharmacokinetic theory of controlled release systems
We have systematically investigated the pharmacokinetic theory of the controlled/sustained release systems, and published a monograph titled as pharmacokinetics of controlled/sustained release systems (Science Press, May, 2009), which is a multidisciplinary work of pharmacokinetics and DDS as the first monograph in this field, providing theory and methodology for the quantitative design of in vitro release characteristics of DDS and in vivo pharmacokinetic evaluation.
2. Structures Pharmaceutics
Characterization methods for conventional dosage forms are mostly qualitative assessment. In our work, the synchrotron radiation facility met with the evaluation of DDS in view of the 3D and fractal dimension quantitative analysis for structure of formulations on the sub-micron and micron level. These works quantitatively correlated the release characteristics of formulations with its complex structures. Four levels of structures of formulations, namely, structure of molecules, structure of molecular assemblies, structure of particles and crystals, structure of dosage forms, were defined with 3D release theories and methods for design and optimization of DDS.
3. Study on supramolecular systems and drug release mechanism
Supramolecular systems based on cyclodextrins were studied for mechanism of the drug release kinetics. Supramolecular drug delivery systems using CD-MOF were developed for controlled release and inhalations.
4. Research on novel drug delivery systems
Based on structural innovation, new types of tablets, e.g., dynamic structural osmotic pump tablets driven by liquid droplets formed spontaneously in situ in semi-solid matrix and tablets with cage-like structures, have been designed. Dry powders for inhalers were investigated for natural product from TCMs and new compound. The team is also working on oral DDS for poorly water-soluble drugs and taste masking on bitter drugs for pediatric usages.
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Social Titles
1. Editor Member of the journals: International Journal of Pharmaceutics, Acta Pharmaceutica Sinica B, and Asian Journal of Pharmaceutics.
2. Vice director of Pharmaceutical Excipient Committee, Member of the Pharmaceutics Committee, China Pharmaceutical Association.
3. Member of the Pharmaceutics Committee, Shanghai Pharmaceutical Association.
4. Panel Member of the UK-China Advanced Material Research Institute.
2. Vice director of Pharmaceutical Excipient Committee, Member of the Pharmaceutics Committee, China Pharmaceutical Association.
3. Member of the Pharmaceutics Committee, Shanghai Pharmaceutical Association.
4. Panel Member of the UK-China Advanced Material Research Institute.
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Awards & Honors
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Pubilcations
Full Publication List
Selected Publications
1. Ting Xiong, Huipeng Xu, Qin Nie, Bingqian Jia, Haojie Bao, Hanwen Zhang, Jing Li, Zeying Cao, Shunyao Wang, Li Wu, Jiwen Zhang. Reactive Oxygen Species Triggered Cleavage of Thioketal - Containing Supramolecular Nanoparticles for Inflammation - Targeted Oral Therapy in Ulcerative Colitis. Advanced Functional Materials. 2024. 2411979. https://doi.org/10.1002/adfm.202411979
2. Xiangyu Zhao, Tianfu Li, Tao Guo, Xiaojian He, Xiaohong Ren, Manli Wang, Caifen Wang, Can Peng, Jiwen Zhang, Li Wu. Supramolecular Structure of the β‑Cyclodextrin Metal−Organic Framework Optimizes Iodine Stability and Its Co-delivery with L‑Menthol for Antibacterial Applications. ACS Applied Materials & Interfaces. 2024. 16(19), 24235-24247. https://doi.org/10.1021/acsami.4c02258
3. Huipeng Xu, Li Wu, Yanling Xue, Ting Yang, Ting Xiong, Caifen Wang, Siyu He, Hongyu Sun, Zeying Cao, Jun Liu, Siwen Wang, Zhe Li, Abid Naeem, Xianzhen Yin, Jiwen Zhang. Advances in Structure Pharmaceutics from Discovery to Evaluation and Design. Molecular Pharmaceutics. 2023. 20(9), 4404-4429. https://doi.org/10.1021/acs.molpharmaceut.3c00514
4. Zeying Cao; Yanli Zhao; Hongyu Sun; Xian Sun; Yu Zhang; Shuo Zhang; Caifen Wang; Ting Xiong; Abid Naeem; Jiwen Zhang; Xianzhen Yin. Cross-scale Tracing of Nanoparticles and Tumors at the Single-cell Level Using the Whole-lung Atlas. Science Advances. 2023. 9, eadh7779. https://doi.org/10.1126/sciadv.adh7779
5. Siyu He, Li Wu, Xue Li, Hongyu Sun, Ting Xiong, Jie Liu, Chengxi Huang, Huipeng Xu, Huimin Sun, Weidong Chen, Ruxandra Gref, Jiwen Zhang. Metal-organic Frameworks for Advanced Drug Delivery. Acta Pharmaceutica Sinica B. 2021. 11(8), 2362-2395. https://doi.org/10.1016/j.apsb.2021.03.019
6. Xian Sun, Xiaochuan Zhang, Xiaohong Ren, Hongyu Sun, Li Wu, Caifen Wang, Xiaohui Ye, Peter York, Zhaobing Gao, Hualiang Jiang, Jiwen Zhang, Xianzhen Yin. Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution. Advanced Sciences. 2021. 8 (8), 2003941. https://doi.org/10.1002/advs.202003941
7.Yaping He, Ting Xiong, Siyu He, Hongyu Sun, Chenxi Huang, Xiaohong Ren, Li Wu, Laurence H. Patterson, Jiwen Zhang. Pulmonary Targeting Crosslinked Cyclodextrin Metal-Organic Frameworks for Lung Cancer Therapy. Advanced Functional Materials. 2021, 31, 2004550. https://doi.org/10.1002/adfm.202004550
8.Yuanzhi He, Wei Zhang, Tao Guo, Guoqing Zhang, Wei Qin, Liu Zhang, Caifen Wang, Weifeng Zhu, Ming Yang, Xiaoxiao Hu, Vikramjeet Singh, Li Wu, Ruxandra Gref, Jiwen Zhang. Drug Nanoclusters Formed in Confined Nano-cages of CD-MOF: Dramatic Enhancement of Solubility and Bioavailability of Azilsartan. Acta Pharmaceutica Sinica B. 2019. 9(1), 97-106. https://doi.org/10.1016/j.apsb.2018.09.003
9.Shailendra Shakya, Yaping He, Xiaohong Ren, Tao Guo, Abi Maharjan, Ting Luo, Tingting Wang, Ramesh Dhakhwa, Balmukunda Regmi, Haiyan Li, Ruxandra Gref, and Jiwen Zhang. Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal-Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application. Small. 2019. 15(27), e1901065. https://doi.org/10.1002/smll.201901065
10.Liu Zhang, Li Wu, Caifen Wang, Guoqing Zhang, Lin Yu, Haiyan Li, Abi Maharjan, Yan Tang, Dunwei He, Peter York, Huimin Sun, Xianzhen Yin, Jiwen Zhang, Lixin Sun. Synchrotron Radiation Microcomputed Tomography Guided Chromatographic Analysis for Displaying the Material Distribution in Tablets. Analytical Chemistry. 2018. 90(5), 3238-3244. https://doi.org/10.1021/acs.analchem.7b04726
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