Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

Prof. Gan Yong now serves as the principal investigator of the Centre for Drug Delivery Research in Shanghai institute of Materia Medica (SIMM), Chinese Academy of Science. His major interests focus on physical pharmacy. Specifically, he has designed novel drug delivery systems with further exploration of the underlying mechanisms overcoming the key physiological barriers. He has now published more than 70 peer-reviewed papers in international journals, including Science Advances, Nature Communications, PNAS, Advanced Functional Materials, Advanced Science, ACS Nano, Nano Letters, Biomaterials, Journal of Controlled Release. He has also participated in writing and editing 5 books. In the aspect of translational medicine, Prof. Gan has rationally designed a series of innovative preparations with good druggability, some of which are now undergoing clinical trials. Up to now, he holds 35 authorized patents, 15 clinical approvals for new drugs, and 5 commercial formulations.

Education:

1997.09 - 2002.06 Shenyang Pharmaceutical University, School of Pharmacy, Pharmaceutics, Ph.D.

1993.09 - 1997.06 Shenyang Pharmaceutical University, School of Pharmacy, Pharmacy Analysis, B.S.

Work Experience:

2008.10 - Present Shanghai Institute of Materia Medica, Center for Drug Delivery, Professor

2004.10 - 2008.10 Shanghai Institute of Materia Medica, Center for Drug Delivery, Associate Professor

2002.07 - 2004.07 Shanghai Institute of Materia Medica, Postdoctoral Fellow

Research Directions

1. Research on physical pharmacy;

2. Novel drug carriers design and research on the mechanism of overcoming the key physiological barriers;

3. Translational research on the innovative drug preparations.

Grants & Research Projects

Scientific research projects undertaken：

1．Study on physical pharmacy for efficient delivery of drug carriers，National Natural Science Foundation of China, Project principal, 2021.01-2025.12

2．The Major International Joint Reaearch Project of Chinese Academy of Sciences, Research on efficient intracellular delivery of nanodrug carriers, Project principal, 2020.01-2022.12

3．The Shanghai Science and Technology Committee, The rational shape design of high-efficiency nano-drug carrier and the research on the microscopic movement mechanism to overcome the physiological barrier, Project principal, 2018.11-2020.10

4．National Natural Science Foundation, Research on the influence of nanoparticle shape on the efficiency of oral delivery and the microscopic mechanism to overcome the absorption barrier, Project principal, 2018.01-2021.12

5．The Strategic Priority Research Program of Chinese Academy of Sciences, Research on the preparation technology of drug microcapsules on space microfluidic chip, Project principal, 2018.01-2020.12

6．The Shanghai Science and Technology Committee, The rational shape design of high-efficiency nano-drug carrier and the research on the microscopic movement mechanism to overcome the physiological barrier, Project principal, 2018.10-2020.09

7．The Shanghai Science and Technology Committee, Research on the effect of high bioavailability on the efficiency of drug delivery to overcome the microscopic movement mechanism of absorption barrier, Project principal, 2017.10-2019.09

8．Chinese Academy of Sciences, Wang Kuancheng Leading industry research talent support project, Project principal, 2017.01-2019.12

9．National Natural Science Foundation of China, Design of intelligent polypeptide nano-carriers based on pathological microenvironment of intestinal epithelial cells in diabetes mellitus and research on the mechanism of intercellular transport, Project principal, 2016.01-2019.12

10．CAS-Novo Nordisk Research Foundation, A particle engineering approach to improve the tabletability of poorly compressible absorption enhancers in an oral peptide formulation, Project principal, 2016.01-2017.12

Achievements

1. In the view of physical pharmacy, Prof. Gan has designed novel drug delivery systems with further exploration of the underlying mechanisms overcoming the key physiological barriers. He has revealed the several rules of physical properties, such as shape and rigidity, in determining the delivery efficiency of drug carriers. Meanwhile, he has described the unique rotation-hopping diffusion pattern of rod-shaped carriers and the rod-like microcosmic motion of the semi-elastic carriers, both of which are the mechanisms of their efficient transportation.

2. In the field of translational medicine, he has focused on the development of innovative oral preparations and novel lipid-based injections. Based on proprietary technology, Glipizide Controlled Release Tablets have been approved to be listed. Glumetinib tablet (a first class anticancer drug) and huperzine A controlled-release tablet (an anti-alzheimer’s drug), developed based on absorption and controlled release technologies, also have been approved for clinical trial. In addition, the fish oil nanoemulsion injection with anti-inflammatory effect has been manufactured on a large-scale.

morefold

Social Titles

The Pharmaceutics Committee of Chinese Pharmaceutical Association, Senior Member

The Second Council of China Particle Society, Young Council

The Nanomedicine and Engineering Committee of Chinese Biomedical Engineering Society, Member

Editor of the journal “Asian Journal of Pharmaceutical Sciences”, “Acta Pharmaceutica Sinica B” and “Chinese Journal of Pharmaceuticals”, etc.

Center for Drug Evaluation (NMPA), External Experts

Academic Committee of NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, Member

Expert Committee of National Engineering Research Center Modernization of Extraction and Separation Process of TCM, Member

morefold

Awards & Honors

2020, the Winner of the National Science Foundation for Distinguished Young Scholars of China, The National Nature Science Foundation of China.

2019, the 4th China Pharmaceutical Association - Yiling biomedical Youth Award, China Pharmaceutical Association.

2019, Young and Middle-aged Leading Talents in Science and Technology Innovation of Promotion Plan, Ministry of science and technology.

2017, the Winner of Wang Kuancheng Leading Talent Program, Personnel Bureau of Chinese Academy of Sciences.

2017, Special Researcher of Chinese Academy of Sciences, Personnel Bureau of Chinese Academy of Sciences.

morefold

Pubilcations

Full Publication List

Selected Publications

1.Yan Wei, Sha Song, Nianxiu Duan, Feng Wang, Yuxi Wang, Yiwei Yang, Chengyuan Peng, Junjun Li, Di Nie, Xinxin Zhang, Shiyan Guo, Chunliu Zhu, Miaorong Yu, Yong Gan*.MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy. Advanced Science.2020,1902746

2.Aohua Wang#, Weiwei Fan#, Tiantian Yang, Shufang He, Yiwei Yang, Miaorong Yu, Li Fan, Quanlei Zhu, Shiyan Guo, Chunliu Zhu, Yong Gan*. Liver-target and glucose-responsive polymersomes toward mimicking endogenous insulin secretion with improved hepatic glucose utilization. Advanced Functional Materials. 2020, 30(13):1910168.

3.Di Nie#, Zhuo Dai#, Jialin Li#, Yiwei Yang, Ziyue Xi, Jie Wang, Wei Zhang, Kun Qian, Shiyan Guo, Chunliu Zhu, Rui Wang, Yiming Li, Miaorong Yu, Xinxin Zhang, Xinghua Shi, Yong Gan*. Cancer-cell-membrane-coated nanoparticles with a yolk-shell structure augment cancer chemotherapy. Nano Letters. 2020, 20(2):936-946.

4.Yiwei Yang#, Falin Tian#, Di Nie#, Yuan Liu, Kun Qian, Miaorong Yu, Aohua Wang, Yaqi Zhang, Xinghua Shi*, Yong Gan*. Rapid transport of germ-mimetic nanoparticles with dual conformational polyethylene glycol chains in biological tissues. Science Advances. 2020, 6(6):eaay9937.

5.Shiyan Guo, Di Sun, Dalong Ni, Miaorong Yu, Kun Qian, Wei Zhang, Yiwei Yang, Sha Song, Yang Li, Ziyue Xi, Jie Wang, Jingyi Li, Yan Wei, Kaixian Chen*, Yong Gan*, Zhengtao Wang*. Smart tumor microenvironment-responsive nanotheranostic agent for effective cancer therapy. Advanced Functional Materials. 2020.

6.Zhuo Dai#, Miaorong Yu#, Xin Yi*, Zeming Wu, Falin Tian, Yunqiu Miao, Wenyi Song, Shufang He, Ejaj Ahmad, Shiyan Guo, Chunliu Zhu, Xinxin Zhang, Yiming Li, Xinghua Shi, Rui Wang*, Yong Gan*. Chain-length- and saturation-tuned mechanics of fluid nanovesicles direct tumor delivery. ACS Nano. 2019, 13(7):7676-7689.

7.Miaorong Yu#, Wenyi Song#, Falin Tian#, Zhuo Dai, Quanlei Zhu, Ejaj Ahmad, Shiyan Guo, Chunliu Zhu, Haijun Zhong, Yongchun Yuan, Tao Zhang, Xin Yi, Xinghua Shi*, Yong Gan*, Huajian Gao*. Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels. Proceedings of the National Academy of Sciences of the United States of America. 2019, 116(12):5362-5369.

8.Miaorong Yu#, Lu Xu#, Falin Tian#, Qian Su, Nan Zheng, Yiwei Yang, Jiuling Wang, Aohua Wang, Chunliu Zhu, Shiyan Guo, Xinxin Zhang, Yong Gan*, Xinghua Shi*, Huajian Gao*. Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers. Nature Communications. 2018, 9(1):2607.

9.Shufang He, Weiwei Fan, Na Wu, Jingjing Zhu, Yunqiu Miao, Xiaran Miao, Feifei Li, Xinxin Zhang*, Yong Gan*. Lipid-based liquid crystalline nanoparticles facilitate cytosolic delivery of siRNA via structural transformation. Nano Letters. 2018, 18(4):2411-2419.

10.Miaorong Yu#, Jiuling Wang#, Yiwei Yang#, Chunliu Zhu, Qian Su, Shiyan Guo, Jiashu Sun, Yong Gan*, Xinghua Shi*, Huajian Gao*. Rotation-facilitated rapid transport of nanorods in mucosal tissues. Nano Letters. 2016, 16(11):7176-7182.

morefold