YU Xuekui
Principle Investigator
Research Center for Structure and Function of Drug Targets;Institutional Center for Shared Technologies and Facilities of SIMM, CAS
Personal Homepage
CONTACT
xkyu@simm.ac.cn
021-50801660
201203
501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R. China.
Biography
Dr. YU obtained his bachelor, master and PhD degrees in 1986, 1992 and 1999, from Wuhan University, West China University of Medical Science and Zhongshan University, respectively. He then went to University of Texas Medical School at Houston as a Postdoctoral Fellow, and then promoted as a Scientist and again a Research Assistant Professor to study the structures of viruses and other biological macromolecules by cryo-electron microscopy (cryoEM). In March 2008, he moved to University of California, Los Angeles (UCLA) as an Assistant Professor and then a Project Scientist to study the structures and functions of viruses and other biological macromolecules by high resolution cryoEM. Since July 2017, he has joined the Shanghai Institute of Materia Medica CAS as a principal investigator.
Education
1996.09 - 1999.07 Ph.D., Zoology, Zhongshan University, Guangzhou, China
1989.09- 1992.07 Master, Biochemistry, West China University of Medical Science, Chengdu, China
1982.09 - 1986.07 Bachelor, Microbiology, Wuhan University, Wuhan, China
Work Experience
2017.07 - Current Principal Investigator, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
2014.07 - 2017.06 Project Scientist, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA.
2008.03 - 0214.06 Research Assistant Professor, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA.
2006.04 - 2008.03 Research Assistant Professor, Department of Pathology and Experimental Medicine, Houston School of Medicine, University of Texas, USA.
2004.11 - 2006.04 Scientist, Department of Pathology and Experimental Medicine, Houston School of Medicine, University of Texas, USA.
1999.11 - 2004.11 Postdoctoral Research Fellow, Department of Pathology and Experimental Medicine, Houston School of Medicine, University of Texas, USA.
1992.07 - 1996.09 Research Assistant, Bio-Research Facility, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
1986.07 - 1989.09 Research Assistant, Microbiology Laboratory, The 302nd Hospital of the People's Liberation Army of China, Beijing, China.
Research Directions
1. Structure and function studies of viruses, membrane proteins and other biological macromolecules by high resolution cryoEM
Grants & Research Projects
1. The Natural Science Foundation of Shanghai (18ZR1447700)
2. The Strategic Priority Research Program of the Chinese Academy of Science (XDA12010317)
Achievements
1. The first to propose the “shiny particle” concept to judge the quality of cryoEM images.
2. Determine the first cryoEM structure of virus at near-atomic resolution (Nature. 2008).
3. Reveal the regulatory mechanism of dsRNA virus transcription by cryoEM (eLife, 2015; Nature, 2015).
4. Determine the atomic structure of the human cytomegalovirus (HCMV) capsid, which is also the first herpesvirus capsid structure at atomic resolution (Science, 2017).
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Social Titles
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Awards & Honors
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Pubilcations
Full Publication List
Selected Publications
1.Li, Zhihai#, Zhang, Xiao#, Dong, Lili, Pang, Jingjing, Xu, Miao, Zhong, Qian, Zeng, Musheng*, Yu, Xuekui*. CryoEM structure of the tegumented capsid of Epstein-Barr virus. Cell Research. 2020, 30(10):873-884. doi: 10.1038/s41422-020-0363-0.
2.Yu, Xuekui#, Jih, Jonathan#, Jiang, Jiansen, Zhou, Z Hong*. Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150. SCIENCE. 2017, 356(6345):eaam6892. doi: 10.1126/science.aam6892.
3.Zhang, Xing#, Ding, Ke#, Yu, Xuekui#, Chang, Winston, Sun, Jingchen*, Zhou, Z Hong*. In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. NATURE. 2015, 527(7579):531-534. doi: 10.1038/nature15767.
4.Yu, Xuekui#, *, Jiang, Jiansen, Sun, Jingchen*, Zhou, Z Hong*. A putative ATPase mediates RNA transcription and capping in a dsRNA virus. ELIFE. 2015, 4:e07901. doi: 10.7554/eLife.07901.
5.Yu, Xuekui#, Jin, Lei, Zhou, Z Hong*. 3.88 ？ structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy. NATURE. 2008, 453(7193):415-9. doi: 10.1038/nature06893.
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