XIE Xin
Professor/Ph.D candidate supervisor, Principal Investigator
Immunological Disease Research Center;National Center for Drug Screening;Chinese National Compound Library (CNCL)
Personal Homepage
CONTACT
xxie@simm.ac.cn
+86-21-50801313 ex 156
201203
555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China
Biography
XIE Xin, Ph.D., Principle Investigator of Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Deputy Director of Chinese National Center for Drug Screening; Adjunct Professor of Shanghai Tech University and University of Chinese Academy of Sciences-Hangzhou Institute for Advanced Study. Dr. Xie received her Ph.D. from University of Medicine and Dentistry of New Jersey in 2002, elucidating the neuro-protective roles of gangliosides. Prior to her doctoral work, Dr. Xie obtained her BS in Chemistry from Peking University in 1996.
EDUCATION
1996.09－2002.05, University of Medicine and Dentistry of New Jersey, Ph.D. Program
1991.09－1996.07, Department of Chemistry, Peking University, Bachelor’s program
WORK EXPERIENCE
2005.12－Now, Shanghai Institute of Materia Medica, CAS, Professor, Principle Investigator
2004.05－Now, National Center for Drug Screening, served as Head of Assay Development Departemet II and Deputy Director
2003.07－2004.05, Sine Pharmaceutical, Director of the External Liaison Office
2002.05－2003.06, University of Medicine and Dentistry of New Jersey, PostDoc Fellow
Research Directions
1. The function of GPCR signaling in major diseases (autoimmune diseases, metabolic diseases, neurodegenerative diseases, etc) and drug discovery targeting GPCRs
2. Stem cell fate determination－a chemical biology approach
Grants & Research Projects
1.Natural Science Foundation of China, Free fatty acid receptor as drug target for the treatment of IBD, PI, 2018-2022
2.MOST, Stem Cell Research Major Scientific Research Project, Chemical-mediated somatic cell reprogramming and the underlying mechanism, PI, 2015-2019
Achievements
Prof. Xie's gourp is interested in the biological functions of G protein-coupled receptor (GPCR) and their roles in major diseases including autoimmune disease, neurodegenerative diseases, metabolic diseases and etc. In addition to the mechanism study, they also screen and develop drugs targeting GPCRs. In recent years, Prof. Xie's group also focuses on inducing somatic cell reprogramming using small molecule compounds. They’ve discovered that a number of GPCRs (CysLT1, A2B and KOR) are critically involved in the development of Multiple Sclerosis (MS), an autoimmune disease. These receptors might be explored as new therapeutic targets for the treatment of MS, either by modulating the immune system, or promoting remyelination. They’ve also identified several marketed old drugs might alleviate clinical symptoms of MS, indicating possible drug repositioning opportunity. They’re also among the few top labs that can generate induced pluripotent stem cells (iPSCs) with full chemical induction, and they demonstrated for the first time that in vivo and in situ fibroblasts to cardiomyocytes conversion is possible with small molecule treatment. Prof. Xie's team published more than 100 papers in top journals and applied >30 patents, >10 of them were granted. One of their drug candidates has entered the phase I clinical study and been licensed by a pharmaceutical company.
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Social Titles
2008.12－Now, Acta Pharmacologica Sinica, editorial board member
2014.05－Now, Chinese Society for Cell Biology, member of Stem Cell Committee
2018－Now, Shanghai Society of Pharmacology, board member
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Awards & Honors
The tenth annual award of Chinese Young Woman Scientist (2013)
State Council Expert for Special Allowance (2012)
Shanghai Woman Pace-setter (2011-2012)
CAS Shanghai Branch Distinguished Young Scientists (2012)
National New Century Million Talents Project (2009)
State Council Expert for Special Allowance (2012)
Shanghai Woman Pace-setter (2011-2012)
CAS Shanghai Branch Distinguished Young Scientists (2012)
National New Century Million Talents Project (2009)
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Pubilcations
Full Publication List
Selected Publications
1.Na Suo, Yu-e Guo, Bingqing He, Haifeng Gu, Xin Xie*. Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia, 2019 Jul;67(7):1320-1332.
2.Chenwen Huang, Wanzhi Tu, Yanbin Fu, Xin Xie*. Chemical-induced cardiac reprogramming in vivo. Cell Research, 2018 Jun;28(6):686-689.
3.Haikun Song, Hexuan Li, Shimeng Guo, Yuyin Pan, Yuhua Fu, Zijian Zhou, Zhaoyang Li, Xue Wen, Xiaoli Sun, Bingqing He, Haifeng Gu, Youhong Hu, Xin Xie*, Boxun Lu*. Targeting Gpr52 Lowers Mutant HTT Levels and Rescues Huntington’s Disease-associated Phenotypes. Brain, 2018 Jun 1;141(6):1782-1798.
4.Ren Guo, Wei Tang, Qianting Yuan, Lijian Hui, Xin Wang, Xin Xie*. Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription Factor, Stem Cell Reports, 2017, Aug 8;9(2):499-512.
5.Jiali Jin, Jian Liu, Cong Chen, Zhenping Liu, Cong Jiang, Hongshang Chu, Weijuan Pan, Xinbo Wang, Lingqiang Zhang, Bin Li, Cizhong Jiang, Xin Ge, Xin Xie*, Ping Wang*. The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nature Communications, 2016 Nov 25;7:13594.
6.Changsheng Du, Yanhui Duan, Hui Chai, Yingying Cai, Wei Wei, Jie Lv, Xin Xie*. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination. Nature Communications, 2016 Apr 4;7:11120.
7.Yuan Long, Min Wang, Haifeng Gu, Xin Xie*. Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells. Cell Research, 2015 Oct;25(10):1171-4.
8.Yanbin Fu, Chenwen Huang, Xinxiu Xu, Haifeng Gu, Youqiong Ye, Cizhong Jiang, Zilong Qiu, Xin Xie*. Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. Cell Research, 2015 Sep;25(9):1013-24.
9.Kong X, Liu J, Li L, Yue L, Zhang L, Jiang H, Xie X*, Luo C*. Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition. Nucleic Acids Research, 2015 May 19; 43(9):4381-92.
10.Shuyong Zhang, Yuyong Ma, Jing Li, Biao Yu*, Xin Xie*. Molecular matchmaking between the popular ‘weight loss’ herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorders. Proc Natl Acad Sci U S A, 2014 Oct 7;111(40):14571-6.
11.Guofang Chen, Xinxiu Xu, Lihong Zhang, Yanbin Fu, Min Wang, Haifeng Gu, Xin Xie*. Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cells self-renewal and somatic cell reprogramming. Cell Research, 2014 Sep;24(9):1121-36.
12.Xiaoyuan Wei, Yueting Chen, Yongyu Xu, Yang Zan, Ru Zhang, Min Wang, Qiuhong Hua, Haifeng Gu, Fajun Nan*, Xin Xie*. Small molecule compound induces chromatin de-condensation and facilitate induced pluripotent stem cell generation. Journal of Molecular Cell Biology, 2014 Oct;6(5):409-20.
13.Yongyu Xu, Xiaoyuan Wei, Min Wang, Ru Zhang*, Yanbin Fu, Mingzhe Xing, Qiuhong Hua, Xin Xie*. Proliferation rate of somatic cells affects reprogramming efficiency. Journal of Biological Chemistry. 2013, Apr 5;288(14):9767-78.
14.Feifei Zhang, Wei Wei, Hui Chai, Xin Xie*. Aurintricarboxylic Acid Ameliorates Experimental Autoimmune Encephalomyelitis by Blocking Chemokine-mediated Pathogenic Cell Migration and Infiltration. Journal of Immunology. 2013 Feb 1;190(3):1017-25.
15.Wei Wei, Changsheng Du, Jie Lv, Guixian Zhao, Zhenxin Li, Zhiying Wu, Gy？gy Haskó, Xin Xie*. Blocking A2B Adenosine Receptor alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis via Inhibition of IL-6 Production and TH-17 Differentiation. Journal of Immunology. 2013 Jan 1;190(1):138-46.
16.Xinxiu Xu, Quan Wang, Yuan Long, Ru Zhang, Xiaoyuan Wei, Mingzhe Xing, Haifeng Gu, Xin Xie*. Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Research. 2013 Jan;23(1):131-41.
17.Jie Lv, Changsheng Du, Wei Wei, Zhiying Wu, Guixian Zhao, Zhenxin Li, Xin Xie*. The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis. Journal of Biological Chemistry.2012 Aug 17; 287(34):28656-65.
18.Chang-Sheng Du, Xin Xie*. G Protein-Coupled Receptors as Therapeutic Targets for Multiple Sclerosis. Cell Research. 2012 Jul; 22(7):1108-28.
19.Liefeng Wang, Changsheng Du, Jie Lv, Wei Wei, Ye Cui, Xin Xie*. Antiasthmatic Drugs Targeting the Cysteinyl Leukotriene Receptor 1 Alleviate Central Nervous System Inflammatory Cell Infiltration and Pathogenesis of Experimental Autoimmune Encephalomyelitis. Journal of Immunology. 2011;187(5):2336-45.
20.Quan Wang, Xinxiu Xu, Jun Li, Jing Liu, Haifeng Gu, Ru Zhang, Jiekai Chen, Yin Kuang, Jian Fei, Cong Jiang, Ping Wang, Duanqing Pei, Sheng Ding, Xin Xie*. Lithium, an anti-Psychotic Drug, Greatly Enhances the Generation of Induced Pluripotent Stem Cells. Cell Research. 2011;21(10):1424-35.
21.He X, Fang L, Wang J, Yi Y, Zhang S, Xie X*. Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Research 2008 Nov 1; 68(21):8678-86.
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