LI Jingya
Metabolic Disease Research Center;National Center for Drug Screening;Chinese National Compound Library (CNCL)
Personal Homepage
CONTACT
jyli@simm.ac.cn
021-50801313
201203
189 Guoshoujing Rd, Shanghai
Biography
Dr. Jingya Li obtained Ph.D. degree of Pharmacology from Shanghai Institute of Materia Medica, Chinese Academy of Sciences in 2003. Then she began her research career in National Center for Drug Screening, focusing on the innovative drug discovery of metabolic diseases. As a scholar, Dr. Li visited Garvan Institute of Medical Research in 2005, and participated in the joint Sino-Australia research project. She focuses on the physiology and pathology mechanism for metabolic disease, the discovery of hit compounds and the drug discovery for metabolic diseases. As co-inventor of the drug candidate development, Dr. Li has successfully obtained the three approvals of the clinic study for new molecular entities (NME).
Education
1998.09-2003.06 Ph.D. in Molecular Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1994.09-1998.06 B.S. in Biology, East China of Normal University
Work Experience
2003-present National Center of Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Research Directions
1.Physiology and pathology of metabolic diseases
2.Innovative drug discovery of metabolic diseases
Grants & Research Projects
Achievements
morefold
Social Titles
morefold
Awards & Honors
morefold
Pubilcations
Full Publication List
Selected Publications
1. Nie, LT; Shuai, L; Zhu, MR; Liu, P; Xie, ZF; Jiang, SW; Jiang, HW; Li, J; Zhao, YM; Li, JY*; Tan, MJ*. The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model. MOLECULAR & CELLULAR PROTEOMICS. 2017, 16:1324-1334.
2. Wu,LY; Zhang,LN; Li,BH; Duan,YN; Xie,ZF; Shuai,L; Li,J*; Li,JY*. AMP-activated protein kinase(AMPK) regulates energy metabolism through modulating thermogenesis in adipose tissue. FRONTIERS IN PHYSIOLOGY. 2018,9:122.
3. Wu, LY#; Xia, MF#; Duan, YN#; Zhang, LN; Jiang, HW; Hu, XB; Yan HM; Zhang, YQ; Gu, YS; Shi, HC; Li, J*; Gao, X* and Li, JY*. Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans. CELL DEATH & DISEASE. 2019,10:468.
4. Shuai, L#; Zhang, LN#; Li, BH#; Tang, CL; Wu, LY; Li, J* and Li, JY*. SIRT5 regulates brown adipocyte differentiation and browning of subcutaneous white adipose tissue. DIABETES, 2019, 68: 1449-1461.
5. Jiang, HW; Jin, J; Duan, YN; Xie, ZF; Li, YF; Gao, AH; Gu, M; Zhang, XW; Peng, C; Xia, CM; Dong, TC; Li, H; Yu, LF; Tang, J; Yang, F*; Li, JY* and Li, J*. Mitochondrial uncoupling coordinated with PDH activation safely ameliorates hyperglycemia via promoting glucose oxidation. DIABETES, 2019, 68:2197-2209.
morefold
Back