XU Huaqiang
Director Center for Structure &Function of Drug Targets;Director Key Laboratory of Receptor Research, SIMM,CAS
Research Center for Structure and Function of Drug Targets
Personal Homepage
CONTACT
eric.xu@simm.ac.cn
021-20231976
201203
501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China. 201203
Biography
Dr. XU obtained his bachelor and master degrees in 1985 and 1988, both from Tsinghua University in Beijing China. He then went to Duke University and the University of Texas Southwestern Medical Center, where he earned his Ph.D. in molecular biology and biochemistry in 1994. Following a postdoctoral fellowship with Carl Pabo at MIT, he moved to GlaxoWellcome in 1996 as Research Investigator I. He was promoted to Investigator II in 1999 and again to Senior Investigator in 2001. Dr. XU joined VARI as a Senior Scientific Investigator in July 2002 and became a Distinguished Investigator/Professor in March 2007. In July 2010, Dr. XU established and served as the distinguished Director of the VARI-SIMM Center for Drug Discovery at Shanghai Institute of Materia of Chinese Academy of Sciences. In 2013, he helped to establish and serve as the founding Director of the Key Laboratory of Receptor Research of Chinese Academy of Sciences. He returned to China full time in 2019.
Research Directions
Research in his group covers structures and drug discovery of nuclear hormone receptors, hepatocyte growth factor and its receptor Met tyrosine kinase, G-protein coupled receptors, and plant hormones.
Grants & Research Projects
1.Strategic Priority Research Program of CAS, Study on the structure and function of important brain cognitive neurotransmitter receptors in complex with ligands and downstream signal transductive protein, 2020.01-2024.12.
2.973, Ministry of Science and Technology (MOST), China, Structural and functional research on Ion channels and membrane transport protein, 2013.1-2017.8
3.Special major science and technology, Key technology development and platform construction of drug discovery based on GPCR structure and function, 2012.1-2015.12
4.National Natural Science Foundation, Research on the structure and function of ion channel associated with nervous system disease, 2012.1-2015.12
5.National Natural Science Foundation, The research of Strigolactone's signal transduction pathway, 2013.1-2015.12
Achievements
Dr. XU has been an author of more than 210 scientific papers, many of which are in high-impact journals. His papers have been cited over 23000 times. Two of his research papers on plant hormone signaling were selected as top 10 breakthroughs by Science in 2009 and by Chinese Academy of Sciences in 2014. His recent X-ray laser structure of the first GPCR-arrestin complex was also selected as a top 10 breakthrough by Chinese Academy of Sciences in 2015. He was recognized with the 2016 Hans Neurath Award of Protein Society and the 2016 Wuxi outstanding achievement award. In 2020, he was awarded the "Magnolia Silver Award" in Shanghai.
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Social Titles
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Awards & Honors
Sept. 2020: "Magnolia Silver Award" in Shanghai
Sept. 2019: "Excellent tutor award of Chinese Academy of Sciences"
Dece.2016: "Wuxi life chemistry research award" Outstanding Achievement Award
July. 2016: The Hans Neurath Award, The Protein Society
Sept. 2001, The GlaxoSmithKline Research Excellence Award
Dec. 1999, The GlaxoWellcome Research Excellence Award
Nov. 1993, Research Award in the Twenty-Fifth Sigma Xi Graduate Student Forum, UT Southwestern Medical Center, Dallas, TX
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Pubilcations
Full Publication List
Selected Publications
1.Yu-Qi Ping, Chunyou Mao, Peng Xiao, Ru-Jia Zhao, Yi Jiang, Zhao Yang,Wen-Tao An, Dan-Dan Shen, Fan Yang, Huibing Zhang, Changxiu Qu, Qingya Shen，Caiping Tian, Zi-jian Li, Shaolong Li, Guang-Yu Wang, Xiaona Tao, Xin Wen,Ya-Ni Zhong, Jing Yang, Fan Yi, Xiao Yu, H. Eric Xu, Yan Zhang & Jin-Peng Sun. Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex. Nature. Published: 06 January 2021,https://www.nature.com/articles/s41586-020-03083-w
2.Ting-Hai Xu, Minmin Liu, X Edward Zhou, Gangning Liang, Gongpu Zhao, H Eric Xu, Karsten Melcher, Peter A Jones. Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature 2020,586 (7827):151-155.
3.Yin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science,26 Jun 2020:368(6498): 1499–1504.Xing C, Zhuang Y, Xu TH, Feng Z, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, Xu HE, Xie XQ. Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex. Cell. 2020 Feb 20;180(4):645-654.e13. doi: 10.1016/j.cell.2020.01.007. Epub 2020 Jan 30.
4.Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D1, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y. Structure and dynamics of the active human parathyroid hormone receptor-1. Science. 2019 Apr 12;364(6436):148-153. doi: 10.1126/science.aav7942.
5.Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE. Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature. 2018 Jun;558(7711):553-558.
6.Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F. Crystal structure of Frizzled 4 receptor in ligand-free state. Nature. 2018 Aug;560(7720):666-670. doi: 10.1038/s41586-018-0447-x. Epub 2018 Aug 22.
7.Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE. Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. Cell. 2017 Jul 27;170(3):457-469.e13. doi: 10.1016/j.cell.2017.07.002.
8.Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MHE, Zhang C, Moeller A, West GM, Eps NV, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet1 S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad C, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I , Fromme R, Yi Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B6, Caffrey M, Jiang H, Chapman HN, Spence JCH, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens, RC, Cherezov V, Melcher K, and Xu HE. (2015) Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature. 2015 Jul 30;523(7562):561-7. doi: 10.1038/nature14656. Epub 2015 Jul 22. PMID: 26200343
9.Pal K, Melcher K*, and HE Xu* (2013) Structure Modelling Using Genetically-Engineered Crosslinking. Cell 2013 Dec 5;155(6):1207-8. doi: 10.1016/j.cell.2013.11.018.
10.Jiang L, Liu X, Xiong GS, Liu HH, Chen F, Wang L, Meng XB, Liu GF, Yu Y, Yuan YD, Yi W, Zhao LH, Ma HL, He YZ, Wu ZS, Melcher K, Qian Q, Xu HE*, Wang YH* & Li JY*. (2013) DWARF 53 acts as a repressor of strigolactone signalling in rice. Nature. 2013 Dec 19;504(7480):401-5. doi: 10.1038/nature12870. Epub 2013 Dec 11.
11.Chen C, Ke J, Zhou XE, Yi W, Brunzelle JS, Li J, Yong E-L*, Xu HE*, and Melcher K*. (2013) Structural basis for molecular recognition of folic acid by folate receptors. Nature. 2013 Aug 22;500(7463):486-9. doi: 10.1038/nature12327. Epub 2013 Jul 14. PMID: 23851396 (Highlighted by Chemical Engineering News).
12.Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, Bai F, Yang H, Yang L, Jiang H, Roth BL, Cherezov V, Stevens RC*, Xu HE*. (2013) Structural Basis for Molecular Recognition at Serotonin Receptors. Science. 2013 May 3;340(6132):610-4. doi: 10.1126/science.1232807. PMID: 23519210; PMCID: PMC3644373 (Commented by Science, Nature, and Chemical Engineering News)
13.Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC. (2013) Structural Features for Functional Selectivity at Serotonin Receptors. Science. 2013 May 3;340(6132):615-9. doi: 10.1126/science.1232808. PMID: 23519215; PMCID: PMC3644390 (Commented by Science, Nature, and Chemical Engineering News)
14.Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, Yong EL, Cutler S, Zhu JK, Griffin PR, Melcher K, Xu HE. (2012) Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases. Science, 2012 Jan 6;335(6064):85-8. Nov 24. [Epub ahead of print] (Commented by Science). PMID: 22116026; PMCID: PMC3584687
15.Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE (2009) A gate-latch-lock mechanism for hormone signaling by abscisic acid receptors. Nature 2009 Dec 3;462(7273):602-8 (Cover Article, featured as one of top 10 breakthroughs of 2009 by Science). PMID: 19898420; PMCID: PMC2810868
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