YANG Caiguang
Principal Investigator
Chemical Biology Research Center
Personal Homepage
CONTACT
yangcg@simm.ac.cn
021-50806029
201203
555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China
Biography
Cai-Guang Yang received his Bachelor of Chemical Engineering from Huazhong University of Science and Technology in 1997. He earned his PhD in Organic Chemistry on the total synthesis of natural products from Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CAS) in 2002. He moved to the University of Chicago to begin his post-doctoral training in the Chemistry Department. After six years of post-doctoral work at the interface of chemistry and biology, he returned to Shanghai Institute of Materia Medica, CAS in 2008 to start his independent research and has been appointed as a professor. His research interests are in the field of Medicinal Chemistry, Structure Biology, and Chemical Biology related to RNA methylation, antimicrobial resistance, small-molecule inhibitor/activator, and drug discovery.
Education:
1997.09 - 2002.06 Shanghai Institute of Organic Chemistry, PhD (Advisor, Prof. Biao Jiang)
1993.09 - 1997.06 Huazhong University of Science and Technology, BS in Chemistry
Work Experience:
2020.01-Present Professor, School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study
2008.05-Present Professor, The Center for Chemical Biology, Shanghai Institute of Materia Medica
2002.12-2008.04 Research Associate/Scientist, Chemistry Department, The University of Chicago
Research Directions
The research in the Yang lab mainly focuses on “development of chemical probes for functional modulation of untargeted proteins”, which is a cutting-edge direction in the field of chemical biology and impacts on drug discovery significantly.
Grants & Research Projects
1. Pujiang Program,Shanghai Science and Technology Committee The application of chemical biology and structure biology in drug discovery, Project Leader, 2009.7–2011.6
2. National Natural Science Foundation of China, Structure-based development of inhibitors for SrtA and its mechanism study, Project Leader, 2010.1–2012.12
3. National Natural Science Foundation of China, Signal transduction and chemical regulation in Staphylococcus epidermidis, Project Leader, 2010.1–2012.12
4. National Natural Science Foundation of China, Studies of Clp protease in chemical biology, Project Leader, 2012.1–2015.12
5. Special Project for “Significant New Drugs Development” during the Twelfth Five-year Plan, Techniques in the screening and validation of novel targets for antibacterial drug discovery, Project Leader, 2013.1–2015.12
6. National Natural Science Foundation of China, Studies of mechanism and inhibitors for RNA demethylases, Project Leader, 2014.1–2017.12
7. Integrated Project of National Natural Science Foundation of China, Chemical biology of the regulation of signal transduction by cell plasticity, Project Co-Leader, 2014.1–2015.12
Achievements
Research progresses have been achieved that include 1) the identification of small-molecule regulators that modulate bacterial virulence and revealing the molecular mechanisms, 2) the discovery of chemical probes that selectively inhibit the demethylation of FTO and monitor the cellular location of FTO thus impacts the cellular m6A in mRNA, and 3) the first validation of the SPOP-substrate protein interaction as a truly attractive target specific to kidney cancer that may yield novel drug discovery efforts. These studies aid to understand the function and mechanism of untargeted proteins better in molecular precision and provide the high-value chemical probes potential for basic biology and drug discovery.
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Social Titles
RSC Chemical Biology, Associate Editor
Chinese Journal of Chemistry, Editorial Board Member
Division of Chemical Biology of Chinese Chemical Society, Committee Member
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Awards & Honors
1. 2018 Chemical Biology Award of the Chinese Chemical Society
2. 2017 The National Science Fund for Distinguished Young Scholars
3. 2017 The National Wanren Plan
4. 2017 Shanghai Academic Research Leader
5. 2015 Youth Science and Technology Innovation Leader
6. 2014 WuXi PharmaTech Life Science and Chemistry Award
7. 2009 Shanghai Pujiang Talent
8. 2002 Prize of the President Scholarship of CAS
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Pubilcations
Full Publication List
Selected Publications
1.Ze Dong#, Zhen Wang#, Zhong-Qiang Guo, Shouzhe Gong, Cheng Luo, Jiang Liu, Hualiang Jiang, Cai-Guang Yang*, “Structure-activity relationship of SPOP inhibitors against kidney cancer”, J. Med. Chem. 2020, 4849-4866.
2.Teng Yang#, Tao Zhang#, Xiangna Guan, Ze Dong, Lefu Lan, Song Yang*, Cai-Guang Yang*. “Tideglusib and analogs as inhibitors of Staphylococcus aureus SrtA”, J. Med. Chem., 2020, 63, 8442-8457.
3.Lin-Lin Zhou, Cai-Guang Yang*. “Targeting epitranscriptomic proteins for therapeutic intervention”, Biochemistry, 2020, 59, 125-127. (Special Issue: Future of Biochemistry: The Asia-Pacific Issue)
4.Yue Huang#, Rui Su#, Yue Sheng#, Lei Dong#, Ze Dong#, Hongjiao Xu, Tengfeng Ni, Zijie Scott Zhang, Tao Zhang, Chenying Li, Li Han, Zhenyun Zhu, Fulin Lian, Jiangbo Wei, Qiangqiang Deng, Yungui Wang, Mark Wunderlich, Zhiwei Gao, Guoyu Pan, Dafang Zhong, Hu Zhou, Naixia Zhang, Jianhua Gan, Hualiang Jiang, James C. Mulloy, Zhijian Qian*, Jianjun Chen*, Cai-Guang Yang*. “Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia”, Cancer Cell, 2019, 35, 677-691.
5.Teng Yang#, Tingting Liu#, Jianhua Gan, Kunqian Yu, Kaixian Chen, Wei Xue, Lefu Lan, Song Yang*, Cai-Guang Yang*. “Structural insights into the molecular mechanism of Staphylococcus aureus Stp1 phosphatase”, ACS Infect. Dis., 2019, 5, 841-850.
6.Guijie Liu#, Xing Liu#, Hongjiao Xu, Xichun Liu, Hu Zhou, Zhen Huang, Jianhua Gan, Hao Chen, Lefu Lan, Cai-Guang Yang*. “Structural insights into the redox-sensing mechanism of MarR-type regulator AbfR”, J. Am. Chem. Soc. 2017, 139, 1598-1608.
7.Zhong-Qiang Guo#, Tong Zheng#, Baoen Chen#, Cheng Luo#, Sisheng Ouyang#, Shouzhe Gong, Jiafei Li, Liu-Liang Mao, Fulin Lian, Yong Yang, Yue Huang, Li Li, Jing Lu, Bidong Zhang, Luming Zhou, Hong Ding, Zhiwei Gao, Liqun Zhou, Guoqiang Li, Ran Zhou, Ke Chen, Jingqiu Liu, Yi Wen, Likun Gong, Yuwen Ke, Shang-Dong Yang, Xiao-Bo Qiu, Naixia Zhang, Jin Ren, Dafang Zhong, Cai-Guang Yang*, Jiang Liu*, Hualiang Jiang*. “Small-molecule targeting of E3 ligase adaptor SPOP in kidney cancer”, Cancer Cell, 2016, 30, 474-484.
8.Tengfeng Ni#, Fei Ye#, Xing Liu#, Jie Zhang#, Hongchuan Liu, Jiahui Li, Yingyi Zhang, Yinqiang Sun, Meining Wang, Cheng Luo, Hualiang Jiang, Lefu Lan, Jianhua Gan, Ao Zhang, Hu Zhou, Cai-Guang Yang*, “Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure”, ACS Chem. Biol., 2016, 11, 1964-1972.
9.Qi Li, Xichun Liu, Yue Huang, Jiafei Li, Jianhua Gan, Hao Chen, Cai-Guang Yang*. “Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage”, J. Biol. Chem. 2016, 291, 11083-11093.
10.Tianlu Wang#, Tingting Hong#, Yue Huang#, Haomiao Su, Fan Wu, Yi Chen, Lai Wei, Wei Huang, Xiaoluan Hua, Yu Xia, Jinglei Xu, Jianhua Gan, Bifeng Yuan, Yuqi Feng, Xiaolian Zhang, Cai-Guang Yang*, Xiang Zhou*, “Fluorescein derivatives as bifunctional molecules for the simultaneous inhibiting and labeling of FTO protein”, J. Am. Chem. Soc. 2015, 137, 13736-13739.
11.Yue Huang#, Jingli Yan#, Qi Li, Jiafei Li, Shouzhe Gong, Hu Zhou, Jianhua Gan, Hualiang Jiang, Gui-Fang Jia*, Cheng Luo*, Cai-Guang Yang*. “Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5”, Nucleic Acids Res. 2015, 43, 373-384.
12.Jie Zhang#, Hongchuan Liu#, Kongkai Zhu#, Shouzhe Gong, Shaynoor Dramsi, Ya-Ting Wang, Jiafei Li, Feifei Chen, Ruihan Zhang, Lu Zhou, Lefu Lan, Hualiang Jiang, Olaf Schneewind*, Cheng Luo*, Cai-Guang Yang*. “Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase”, Proc. Natl. Acad. Sci. USA. 2014, 111, 13517-13522.
13.Yue Ding, Xing Liu, Feifei Chen, Hongxia Di, Bin Xu, Lu Zhou, Xin Deng, Min Wu, Cai-Guang Yang*, Lefu Lan*, “A metabolic sensor governing bacterial virulence in Staphylococcus aureus”, Proc. Natl. Acad. Sci. USA, 2014, 111, E4981-E4990.
14.Xing Liu, Xiaoxu Sun, Youcong Wu, Cen Xie, Wenru Zhang, Dan Wang, Xiaoyan Chen, Di Qu, Jianhua Gan, Hao Chen, Hualiang Jiang, Lefu Lan*, Cai-Guang Yang*. “Oxidation-sensing Regulator AbfR Regulates Oxidative Stress Responses, Bacterial Aggregation, and Biofilm Formation in Staphylococcus epidermidis”, J. Biol. Chem. 2013, 288, 3739-3752.
15.Fei Ye#, Jie Zhang#, Hongchuan Liu, Rolf Hilgenfeld, Ruihan Zhang, Xiangqian Kong, Lianchun Li, Junyan Lu, Xinlei Zhang, Donghai Li, Hualiang Jiang*, Cai-Guang Yang*, Cheng Luo*. “Helix Unfolding/refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease”, J. Biol. Chem. 2013, 288, 17643-17653.
16.Chengqi Yi, Baoen Chen, Bo Qi, Wen Zhang, Guifang Jia, Liang Zhang, Charles Q. Li, Aaron R. Dinner, Cai-Guang Yang*, Chuan He*. “Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage”, Nat. Struct. Mol. Biol. 2012, 19, 671-676.
17.Baoen Chen#, Fei Ye#, Lu Yu#, Guifang Jia, Xiaotian Huang, Xueju Zhang, Shuying Peng, Kai Chen, Meining Wang, Shouze Gong, Ruihan Zhang, Jinya Yin, Haiyan Li, Yiming Yang, Hong Liu, Jiwen Zhang, Haiyan Zhang, Ao Zhang, Hualiang Jiang, Cheng Luo*, Cai-Guang Yang*. “Development of Cell-active N6-Methyladenosine RNA Demethylase FTO Inhibitor”, J. Am. Chem. Soc. 2012, 134, 17963-17971.
18.Jie Zhang#, Fei Ye#, Lefu Lan, Hualiang Jiang, Cheng Luo*, Cai-Guang Yang*. “Structural Switches of Staphylococcus aureus Clp Protease: a key to understanding protease dynamics” J. Biol. Chem. 2011, 286, 37590-37601.
19.Hao Chen*, Chengqi Yi, Jin Zhang, Wenru Zhang, Zhiyun Ge, Cai-Guang Yang*, Chuan He*. “Structural Insight into the Oxidation-sensing Mechanism of the Antibiotic Resistance of Regulator MexR” EMBO Rep. 2010, 11, 685-690.
20.Baoen Chen, Hongchuan Liu, Xiaoxu Sun, Cai-Guang Yang*. “Mechanistic Insight into the Recognition of Single-stranded and Double-stranded DNA Substrates by ABH2 and ABH3” Mol. BioSyst. 2010, 6, 2143-2149.
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