Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

Dr. DING Kan is a professor and principal investigator in Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Dr. DING Kan got his M. Sc. degree in pharmacognosy in 1996 in China Pharmaceutical University, and achieved Ph. D. degree in organic chemistry in 1999 in Shanghai Institute of Materia Medica, Chinese academy of sciences. In 1999, he did his postdoctoral training in Lund University in Sweden. Since 2001, he worked as a postdoctoral research fellow associate in University of California, Irvine and a research fellow in Massachusetts General Hospital, Harvard Medical School in U. S. A. During the postdoctoral training, he embarked on the glycobiology study on the structure and function of cell membrane proteoglycan in tumor. In the end of 2005, he was recruited as a full professor by Shanghai Institute of Materia Medica, Chinese academy of sciences. He succeeded in the grant application of National Science Fund for Distinguished Young Scholars of China in 2011.

EDUCATION

1.1996.09-1999.09, Ph.D. in Organic Chemistry in Shanghai Institute of Materia Medica, Chinese Academy of Sciences (Shanghai, China)

2.1993.09-1996.09, M.Sc. in Pharmacognosy in China Pharmaceutical University (Nanjing, China)

WORK EXPERIENCE

1.2021.06-present, Professor, Principal Investigator, Glycochemistry & Glycobiology Lab in Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China; Executive Vice-President, Professor, Principal Investigator, Zhongshan Institute for Drug Discovery, SIMM, CAS

2.2021.06-2021.12, Professor, Principal Investigator, Glycochemistry & Glycobiology Lab in Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China; Professor, Principal Investigator, Director of sugar drug R & D Center in Zhongshan Institute for Drug Discovery, SIMM, CAS

3.2005.12-2021.06, Professor, Principal Investigator, Glycochemistry & Glycobiology Lab in Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

4.2004.01-2005.12, Research fellow, Neurosciences Center in Massachusetts General Hospital/Harvard Medical School (Boston, U.S.A.)

5.2001.11-2004.01, Research Fellow associate in Department of Cell and Developmental Biology in University of California, Irvine (Irvine, U.S.A.)

6.1999.09-2001.11, Postdoctoral Fellow, in Department of Cell and Molecular Biology in Lund University (Lund, Sweden)

7.1986.08-1993.09, Instructor, Jiangsu Pharmaceutical School, Jiangsu, China

Research Directions

Structure and function, structure-activity relationship, targeting, and the mechanism underlying action of polysaccharides from traditional Chinese medicine, interaction between bioactive polysaccharide and gut microbiota, and functional mechanism of cell membrane proteoglycan and its related enzymes. In addition, he also tries to discover new target for glycan-based drug discovery and engage in carbohydrate-based drug development. At present, there are 36 members in his group.

Grants & Research Projects

So far, he has obtained 28 grants, including State Key Program of National Natural Science of China, the National Natural Science Foundation of Science Fund for Distinguished Young Scholars, National Natural Science Foundation, Major National Science and Technology projects: Major New Drug Candidate Drugs, National Science and Technology Major Projects for Key Techniques, Strategic Priority Research Program of the Chinese Academy of Sciences, National High-Tech R&D Program of China, etc., and took part in 10 projects including National Program on Key Basic Research Project (973 Program)， Key projects of the Ministry of Science and Technology.

Achievements

1. Structure and function of Glce

2. Function of MicroRNAs in angiogenesis probed by glycans

3.Targets discovery of polysaccharide and the underlying mechanism

4. The effects and the mechanism of anti-angiogenesis polysaccharides

5. The mechanism underlying polysaccharide uptake in intestinal cells

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Social Titles

1.Participating investigator, Consortium for Functional Glycomics, U.S.A.

2.Participating investigator, “Human Glycome Project”,

3.Associate editor of Carbohydrate Research; associate editor of Glycoconjugate Journal; associate editor of Journal of Carbohydrate Chemistry

4.Consulting expert, China Food and Drug Administration

5.Director of sugar drug R & D Center, Zhongshan Institute for Drug Discovery, SIMM, CAS

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Awards & Honors

1. 01/2017, The first prize of Science and Technology in Guangdong Province

2. 01/2016, Outstanding Academic Leader in Shanghai

3. 12/2011, The National Natural Science Foundation for Distinguished Young Scholars of China

4. 09/2006, “Pujiang Talent Program” in Shanghai

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Pubilcations

Full Publication List

Selected Publications

One book entitled“The structure, function their bioactive mechanism of polysaccharides from traditional Chinese medicine”has been issued under his general editorship. He also published three chapters in Advanced Medicinal Chemistry and the Extraction and Separation of Active Components in Traditional Chinese Medicine. He has published 160 papers, including on international journal, such as J. Hepatol., Angew. Chem. Int. Ed. Engl., J. Cell Biol., J. Am. Chem. Soc., Carbohydr. Polym, and filed 64 national and international patents.

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