Principle Investigator, Mentor of Ph.D. students
Infectious Disease Research Center
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CONTACT
fuqingshan@simm.ac.cn
Guangdong Province Zhongshan Cuihen New Area
Qingshan (Bill) Fu, Professor, Principle Investigator. Received Ph.D. degree in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences in 2010. From January 2011 to December 2018, Bill worked as a Postdoc in James Chou Lab in Harvard Medical School. Using solution NMR method solved the first transmembrane trimer structure of TNFR family receptors. Solved the structures of membrane adjacent region of HIV1 Envelope-protein. January 2019 to September 2021, Bill was assigned the Instructor’s position and worked on HIV Envelope protein, SARS-COV2 spike protein, and screening for drugs to inhibit virus infection. Now, Bill works as a Principle Investigator in Shanghai Institute of Materia Medica and Zhongshan Institute for Drug Discovery.
Education Experience:
Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of sciences. Ph.D. Major: Biochemistry and Molecular Biology.
Work Experience:
Zhongshan Institute for Drug Discovery, Structure Biology Center.
NMR, membrane protein structure, Anti-virus drug mechanism.
National Natural Science Foundation of China (Grant 32271320)
Creative Research Group of Zhongshan City (Lingnan Pharmaceutical Research and Innovation team CXTD2022011).
Full Publication List
Selected Publications
1. Liu T, Ning J, Fan X, Wei H, Shi G*, Fu Q.B.* Identification of immune patterns in idiopathic pulmonary fibrosis patients driven by PLA2G7-positive macrophages using an integrated machine learning survival framework. Scientific Reports. (2024) 14(1):22369. PMID: 39333367.
2. Chen J, Wang Y, Lin S, Yu Q, Qi Z, Jiang W, Zhao Q*, Fu Q.B.* Interaction between membrane curvature sensitive factors SpoVM and SpoIVA in Bicelle condition. Biochemical and Biophysical Research Communications. 694 (2024) 149395. PMID: 38141557.
3. Fu Q, Chou JJ*. (2021) A trimeric hydrophobic zipper mediates the intramembrane assembly of SARS-CoV-2 spike. J Am Chem Soc. 143(23),8543-8546. PMID:34086443.
4. Piai A#, Fu Q#, Sharp AK#, Bighi B, Brown AM*, Chou JJ*. (2021) NMR Model of the Entire Membrane-Interacting Region of the HIV-1 Fusion Protein and Its Perturbation of Membrane Morphology. J Am Chem Soc. 143(17), 6609-6615.
5. Fu Q#, Piai A#, Chen W#, Xia K, Chou JJ*. (2019). Structure Determination Protocol for Transmembrane Domain Oligomers. Nature Protocols 14, 2483-2520. PMID:31270510
6. Fu Q#, Shaik MM#, Cai Y, Ghantous F, Piai A, Peng H, Rits-Volloch S, Liu Z, Harrison SC*, Seaman MS, Chen B*, Chou JJ*. (2018).Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proc Natl Acad Sci USA, 115(38):E8892-E8899 PMID:30185554
7. Fu Q#, Fu T#, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H*, Chou JJ*. (2016). Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Molecular Cell, 61(4):602-613 PMCID: PMC4761300
8. Piai A#, Fu Q#, Cai Y, Ghantous F, Xiao T, Shaik M, Peng H, Rits-Volloch S, Chen W, Seaman M, Chen B*, Chou JJ*. (2020). Structural Basis of Transmembrane Coupling of the HIV-1 Envelope Glycoprotein. Nature Communications, 11 (1) 1-12 PMID: 32385256
9. Piai A#, Fu Q#, Dev J, Chou JJ*. (2017). Optimal Bicelle Size q for Solution NMR Studies of the Protein Transmembrane Partition. Chemistry, 23(6): 1361-1367 PMID: 27747952
10. Fu Q, Zhou C, Gao H, Jiang Y, Zhou Z, Hong J, Yao W, Song A, Lin D*, Hu H*. (2009). Structural basis for ubiquitin recognition by a novel domain from human phospholipase A2-activating protein. J Biol Chem 284, 19043-19052 PMID: 19423704
11. Xiao T#, Frey G#, Fu Q, Lavine CL, Scott DA, Seaman MS, Chou JJ, Chen B*.HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes. Nature Chemical Biology, 16 (5) 529-537 (2020). PMID:32152540
12. Chen W#, Cai Y#, Fu Q, Chen B*, Guo J*, Chou JJ*. Unidirectional Presentation of Membrane Proteins in Nanoparticle-Supported Liposomes. Angew Chem Int Ed Engl, 58 (29) 9866-70. (2019). PMID:30990942
13. Pan L#, Fu TM#, Zhao W#, Zhao L#, Chen W, Qiu C, Liu W, Liu Z, Piai A, Fu Q, Chen S*, Wu H*, Chou JJ*. Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell, 176(6):1477-1489 (2019). PMID:30827683
14. Piai A#, Dev J#, Fu Q, Chou JJ*. Stability and water accessibility of the trimeric membrane anchors of the HIV-1 envelope spikes. J Am Chem Soc, 139(51):18432-18435 (2017). PMID: 29193965
15. Dev J#, Park D#, Fu Q, Chen J, Ha H, Ghantous F, Herrmann T, Chang W, Liu Z, Frey G, Seaman M, Chen B*, Chou JJ*. Structural basis for membrane anchoring of HIV-1 envelope spike. Science, 353(6295):172-175 (2016). PMID: 27338706
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