Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

Qi Li, Ph.D., Principal Investigator of Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Dr. Li received his Ph.D. from Institute of Organic Chemistry, Chinese Academy of Sciences under the supervision of Prof. Yian Shi in 2013. From Aug 2013 through Nov 2020, he worked at Tsinghua University as a postdoctoral researcher and University of California, San Francisco as postdoctoral researcher/associate specialist. Since Nov 2020, Dr. Li has joined in Shanghai Institute of Materia Medica, Chinese Academy of Sciences. His research interests mainly focus on discovering new generation antibiotics to overcome multidrug resistant pathogens.

Education

2009.09 - 2013.07 Ph.D., Organic Chemistry, Institute of Chemistry, the Chinese Academy of Sciences

2006.09 - 2009.07 M.S., Medicinal Chemistry, Shenyang Pharmaceutical University

2000.09 - 2004.07 B.S., Medicinal Chemistry, Shenyang Pharmaceutical University

Work Experience

2020.11-Present Professor, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

2016.01-2020.11 Postdoc/Associate specialist, University of California, San Francisco

2013.08-2016.01 Postdoc Tsinghua University

Research Directions

1. Total synthesis of bioactive natural products

2. Natural products based drug discovery

Grants & Research Projects

Achievements

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Social Titles

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Awards & Honors

1.General Financial Grant (2014M5609500), China Postdoctoral Science Foundation, 2014

2.Postdoctoral fellowship, Center for Life Science, Beijing, China, 2013

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Pubilcations

Full Publication List

Selected Publications

1.Li, Q.; Seiple, I. B. Modular synthesis of streptogramin antibiotics. Synlett 2020, 31, A-H. doi.org/10.1055/a-1293-9655

2.Li, Q.*; Pellegrino, J.*; Lee, D. J.; Tran, A. T.; Chaires, H. A.; Wang, R.; Park, J. E.; Ji, K.; Chow, D.; Zhang, N.; Brilot, A. F.; Biel, J. T.; van Zundert, G.; Borrelli, K.; Shinabarger, D.; Wolfe, C.; Murray, B.; Jacobson, M. P.; Mühle, E.; Cheaneau, O.; Fraser, J. S.; Seiple, I. B. Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature 2020, 586, 145-150. (*equal contribution). doi.org/10.1038/s41586-020-2761-3

3.Shi, X.*; Li, Q.*; Dai, Z.; Tran, A.; Feng, S.; Ramirez, A. S.; Lin, Z.; Wang, X.; Chow, T. T.; Seiple, I. B.; Huang, B. Label-retention expansion microscopy. (*equal contribution). [BioRxiv]. doi.org/10.1101/687954v2

4.Li, Q.; Seiple, I. B. A Concise Route to Virginiamycin M2. Tetrahedron 2019, 75, 3309-3318. (Special issue in honor of Prof. Ryan Shenvi’s Tetrahedron Young Investigator Award). doi.org/10.1016/j.tet.2019.04.060

5.Seiple, I. B.; Li, Q. Method of Making Streptogramin Compositions and the Use Thereof. PCT/US2018/044708.

6.Hu, L.*; Li, Q.*; Yao, L.*; Xu, B.; Wang, X.; Liao, X. Enantioselective and Divergent Syntheses of Alstoscholarisine A, E and their Enantimers. Org. Lett. 2018, 20, 6202-6205. (*equal contribution). doi.org/10.1021/acs.orglett.8b02679

7.Li, Q.; Seiple, I. B. Modular, Scalable Synthesis of Group A Streptogramin Antibiotics. J. Am. Chem. Soc. 2017, 139, 13304-13307. doi.org/10.1021/jacs.7b08577

8.Li, Q.; Xia, T.; Yao, L.; Deng, H.; Liao, X. Enantioselective and Diastereoselective Azo-coupling/Iminium-Cyclization: A Unified Strategy for the Total Synthesis of (-)-Psychotriasine and (+)-Pestalazine B. Chem. Sci. 2015, 6, 3599-3605. doi.org/10.1039/c5sc00338e

9.Li, Q.; Li, G.; Ma, S.; Feng, P.; Shi, Y. An Approach to the Skeleton of Aspidophylline A. Org. Lett. 2013, 15, 2601-2603. doi.org/10.1021/ol4007713

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