Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

Dr. Chen got his Bachelor Degree and PhD from Wuhan University (2005-2015). Then went to Stanford university, Molecular Imaging Program at Stanford (MIPS), Department of Radiology as postdoctoral fellow. He joint Center for Molecular Imaging Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences as a professor from 2019. Dr. Chen focuses on theranostic drug development, concentrates on interdisciplinary research. He devotes himself to developing new molecular imaging technology for faster, cheaper drug development.

Education

2009.9 -2015.6 Ph.D. Biochemistry and Molecular Biology, Wuhan University, Wuhan, China

2005.9 -2009.6 B.S. Pharmacy, Wuhan University, Wuhan, China

Work Experience

2019.2-Current Professor, Center for Molecular Imaging Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

2015.6-2019.2 Postdoctoral fellow, Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, CA, USA

2014.2-2015.6 Joint training Ph.D. student, Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, CA, USA

Research Directions

1.Theranostic drug development (optical, PET-CT, SPECT-CT, etc.);

2.The application of molecular imaging in drug development, including drug target identification, efficacy evaluation, the pharmacokinetics of the biological drug, phase 0 clinical trial, etc.;

3.Radiopharmaceutical chemistry (18F, 68Ga, 89Zr, 3H, 14C, etc.);

4.New imaging system development.

Grants & Research Projects

Shanghai Pujiang Program (19PJ1411100)

National Natural Science Foundation of China (82071976)

Achievements

1. Designed and synthesized the first modifiable NIR-II (SWIR, 1000-1700 nm) fluorescent dye (CH1055) for NIR-II imaging;

2. Developed mitochondria-targeted theranostic probes for fluorescent imaging-guided tumor surgery and chemotherapy.

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Social Titles

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Awards & Honors

1. 2019 Shanghai Pujiang talent program

1. 2017 Student Travel Stipend, World Molecular Imaging Congress (WMIC)

2. 2017 Young Investigator Award (3rd place), Center for Molecular Imaging Innovation and Translation (CMIIT), Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2017 Annual Meeting

3. 2017 Young Investigator Award (2nd place), Chinese American Society of Nuclear Medicine and Molecular Imaging (CASNMMI)

4. 2016 Young Investigator Award (3rd place), Center for Molecular Imaging Innovation and Translation (CMIIT), Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2016 Annual Meeting

5. 2016 Young Investigator Award (1st place), Chinese American Society of Nuclear Medicine and Molecular Imaging (CASNMMI)

6. 2016 Academic Innovation Award of Wuhan University (1st place)

7. 2012 Academic Award for Excellent Ph.D. Candidates funded by the Ministry of Education of China

8. 2012 Wuhan University Zhu Yubi Medical Award

9. 2012 National Award for Postgraduate Students (China)

10. 2012 Academic Innovation Award of Wuhan University (2nd place)

11. 2011 One of the only seven members for “Testing Program for the Training of the Top-notch and Innovative Interdisciplinary Ph.D. training program” of Wuhan University

12. 2010 Wuhan University outstanding student cadres

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Pubilcations

Full Publication List

Selected Publications

1. H. Chen, K. Shou, S. Chen, C. Qu, Z. Wang, L. Jiang, M. Zhu, B. Ding, K. Qian, A. Ji, H. Lou, L. Tong, A. Hsu, Y. Wang, D. W. Felsher, Z. Hu*, J. Tian*, Z. Cheng*. Smart Self‐Assembly Amphiphilic Cyclopeptide‐Dye for Near‐Infrared Window‐II Imaging. Advanced Materials, 2021, 2006902.

2. Y. Yang, X. Fan, L. Li, Y. Yang, A. Nuernisha, D. Xue, C. He, J. Qian*, Q. Hu*, H. Chen*, J. Liu*, W. Huang. Semiconducting Polymer Nanoparticles as Theranostic System for Near-Infrared-II Fluorescence Imaging and Photothermal Therapy under Safe Laser Fluence. ACS Nano, 2020, 14 (2), 2509–2521.

3. H. Chen？, J. Wang？, X. Feng, H, M. Zhu, S. Hoffmann, A. Hsu, K. Qian, D. Huang, F. Zhao, W. Liu, H. Zhang*, Z. Cheng*. Mitochondria-targeted fluorescent molecules for high efficiency cancer growth inhibition and imaging. Chemical Science, 2019, 10, 7946-7951

4. A. Antaris？, H. Chen？, S. Diao, Z. Ma, S. Zhu, C. Leila, W. Joy, L. Alexander, K. Cheng, X. Hong*, H. Dai*, Z. Cheng*. A high quantum yield moleculeprotein complex fluorophore for near-infrared II imaging. Nature Communications, 2016, 8, 15269. (Co-first author)

5. A. Antaris？, H. Chen？, K. Cheng, Y. Sun, G. Hong, C. Qu, S. Diao, Z. Deng, X. Hu, B. Zhang, X. Zhang, O. K. Yaghi, Z. Alamparambil, X. Hong*, Z. Cheng*, H. Dai*. A Small Molecule Dye for NIR II Imaging. Nature Materials, 2015, 15, 235–242. (Co-first author)

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