Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

Dr. XUAN Lijiang, professor, was born in Haining, Zhejiang province in 1967. In 1990 he obtained PhD degree on natural products chemistry in Shanghai Institute of Materia Medica, Chinese Academy of Sciences. His major research interest is to develop modernized TCM and innovative drug based on the chemical and pharmacological investigation of TCM. Till now, he has already obtained 3 drug license, published 80 papers and over 30 Master or PhD student were graduated in his lab. Salvia Miltiorrhiza Depsides Salts, a successful modernized TCM with billions annual sales and applied to millions patients, was his outstanding achievement. Owing to his contribution for the R&D of this innovative drug, he obtained series of important awards in China, such as National Invention award, Outstanding Science and technology achievement Price of Chinese Academy of Sciences.

Education:

09/01/1985-15/07/1990 Shanghai Medical University, Bachelor

09/01/1990-15/07/1995 Shanghai Institute of Materia Medica, CAS, PhD

Work Experience:

16/07/1995-31/07/1996 Shanghai Institute of Materia Medica, CAS, assistant professor

01/08/1996-15/08/1998 Faculty of Pharmaceutical Sciences, Kyushu University, Japan, Post doctor

16/08/1998-current Shanghai Institute of Materia Medica (CAS Associate Professor in Oct. 1998 PI in Mar. 2001 Professor in Feb. 2002)

11/2002-02/2003 Senior visiting scholar in Scripps Institution of Oceanography, UCSD, USA

Research Directions

Majored in natural Products Chemistry. Based on the chemical and pharmacological investigation of TCM or ethnological medicine, to clarify the chemical basis of their pharmacological activity, discover hits and leads, and develop modernized TCM and innovative drug.

Grants & Research Projects

Series of Grants, including National Science & Technology Major Project, National Natural Science Foundation, Strategic Priority Research Program of Chinese Academy of Science and etc. were obtained.

Achievements

New Drug License

1.Salvia Miltiorrhiza Depsides Salts (API)

2.Salvia miltiorrhiza Depsides Salts for infusion

3.S-Adenosylmethionine

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Social Titles

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Awards & Honors

1.12/2007 Shanghai municipal Technological Invention Award, First class (First Inventor)

2.12/2011 National Invention Award, Second class (First Inventor)

3.12/2013 Outstanding Science and technology achievement Price of CAS (Outstanding contributor)

4.12/2014 Tan C. C. Life Science Awards for Industrialization

5.04/2015 Shanghai Outstanding Worker

6.04/2017 National Labor Medal

7.11/2020 National Outstanding Worker

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Pubilcations

Full Publication List

Selected Publications

1.Li HH, Li J, Zhang XJ, Li JM, Xi C, Wang WQ, Lu YL, Xuan LJ*. 23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9. Acta Pharmacol Sin. 2020. 41: 327-335.

2.Yingluo Liu, Xiaoyu Zhou, Lijiang Xuan*. Magnesium lithospermate B ameliorates microcirculation perfusion in rats by promoting vascular NO production via activating the PI3K/AKT pathway. Acta Pharmacologica Sinica. 2019. 40:1010-1018.

3.Fei Gao, Jiaomeng Li, Cong Xi, Huihui Li, Yingluo Liu, Yiping Wang* and Lijiang Xuan*. Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway. Acta Pharmacologica Sinica. 2019. 40: 867-878.

4.Zhihua Wang, Hao Liang, Haijie Cao, Bingjie Zhang, Jun Li, Wenqiong Wang, Shanshan Qin, Yuefei Wang, Lijiang Xuan,* Luhua Lai*, Wenqing Shui*. Efficient ligand discovery from natural herbs by integrating virtual screening, affinity mass spectrometry and targeted metabolomics. Analyst. 2019. 144: 2835-3160.

5.Mike Okweesi Aggrey, Li Hui-Hui , Wang Wen-Qiong , Wang Yiping , Xuan Li-Jiang* . Indole alkaloid from Nauclea latifolia promotes LDL uptake in HepG2 cells by inhibiting PCSK9. Phytomedicine. 2019. 55: 264-268.

6.Jiaojiao Wei, Wenqiong Wang, Weibin Song, Jun Li, Lijiang Xuan*. Three new indole alkaloids from Mappianthus iodoides. Phytochemistry Letters. 2018. 23: 1-4

7.Jiaojiao Wei, Weibin Song, Yefu Zhu, Bole Wei, Lijiang Xuan*. N, N-dimethyl-D-glucosamine as an efficient ligand for copper catalyzed Ullmann-type coupling of N-H heterocycles with aryl halides. Tetrahedron. 2018. 74(1): 19-27.

8.Yong Zheng, Weibin Song, Yefu Zhu, Bole Wei, Lijiang Xuan*. Pd-catalyzed acetoxylation of γ-C(sp3)-H bonds of amines directed by a removable Bts-protecting group. Journal of Organic Chemistry. 2018. 83(4): 2448-2454.

9.Yong Zheng, Weibin Song, Yefu Zhu, Bole Wei, Lijiang Xuan*. Pd-catalyzed intramolecular C(sp2)-H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides. Organic & Biomolecular Chemistry. 2018. 16(14): 2402-2405.

10.Wenqiong Wang, Yanpeng Yin, Jun Li, Lijiang Xuan*. Halimane-type dierpenoids from Vitex rotundifolia and their anti-hyperlipidemia activities. Phytochemistry. 2018. 146: 56-62.

11.Wenqiong Wang, Shanshan Liu, Weibin Song, Jun Li, Lijiang Xuan*. Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities. Phytochemistry. 2018. 149: 24-30.

12.Qingqing Yuan, Shuai Tang, Weibin Song, Wenqiong Wang, Min Huang, Lijiang Xuan*. Crassins A-H, diterpenoids from the roots of Cronton crassifolius. Journal of Natural Products. 2017. 80(2): 254-260.

13.Jun Li，Wenqiong Wang, Shuai Tang, Weibin Song, Ming Huang, Lijiang Xuan*. Pentasaccharide resin glycosides with multidrug resistance reversal activities from the seeds of Pharbitis nil. RSC Advances. 2017. 7(82): 52001-52009.

14.Yong Zheng, Weibin Song, Lijiang Xuan*. The asymmetric total synthesis of (+)-salvianolic acid A. Tetrahedron. 2016. 72(33): 5047-5050.

15.Wenqiong Wang, Lijiang Xuan*. ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities. Phytochemistry. 2016. 122: 119-125

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