Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

Dr. XUAN Lijiang, professor, was born in Haining, Zhejiang province in 1967. In 1990 he obtained his PhD degree on natural products chemistry in Shanghai Institute of Materia Medica, Chinese Academy of Sciences. His primary research focus is on the development of modernized TCM and innovative drugs, drawing on the chemical and pharmacological exploring of TCM. To date, Dr. Xuan has secured 3 drug approvals, published 100 academic papers, and mentored over 40 Master or PhD students. One of his notable achievement is the development of Salvia Miltiorrhiza Depsides Salts, a modernized TCM has achieved annual sales in the billions and has been prescribed to millions of patients. This success has earned him a series of prestigious awards in China, including the National Invention award and the Outstanding Science and technology achievement Price from Chinese Academy of Sciences. He was named as National Outstanding Worker in recognition of his significant contributions to the research and development of new drug.

Education:

09/01/1985-15/07/1990 Shanghai Medical University, Medicinal Chemsitry, Bachelor

09/01/1990-15/07/1995 Shanghai Institute of Materia Medica, CAS, Organic Chemistry, PhD

Work Experience:

16/07/1995-31/07/1996 Shanghai Institute of Materia Medica, CAS, assistant professor

01/08/1996-15/08/1998 Faculty of Pharmaceutical Sciences, Kyushu University, Japan, Post doctor

16/08/1998-current Shanghai Institute of Materia Medica (CAS Associate Professor in Oct. 1998 PI in Mar. 2001 Professor in Feb. 2002)

11/2002-02/2003 Senior visiting scholar in Scripps Institution of Oceanography, UCSD, USA

Research Directions

Majored in natural Products Chemistry. Based on the chemical and pharmacological investigation of TCM or ethnological medicine, to clarify the chemical basis of their pharmacological activity, discover hits and leads, and develop modernized TCM and innovative drug.

Grants & Research Projects

Series of Grants, including National Science & Technology Major Project, National Natural Science Foundation, Strategic Priority Research Program of Chinese Academy of Science and etc. were obtained.

Achievements

New Drug Licenses

1. Salvia Miltiorrhiza Depsides Salts (API)

2. Salvia miltiorrhiza Depsides Salts for infusion

3. S-Adenosylmethionine

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Social Titles

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Awards & Honors

1. 12/2007 Shanghai municipal Technological Invention Award, First class (First Inventor)

2. 12/2011 National Invention Award, Second class (First Inventor)

3. 12/2013 Outstanding Science and technology achievement Price of CAS (Outstanding contributor)

4. 12/2014 Tan C. C. Life Science Awards for Industrialization

5. 04/2015 Shanghai Outstanding Worker

6. 04/2017 National Labor Medal

7. 11/2020 National Outstanding Worker

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Pubilcations

Full Publication List

Selected Publications

1. Tong Chen, Aijun Hou, Pengju Guo, Shou Peng, Guoqing Qin, Aoxue Ding, Xianggang Hu,Yelin Duan, Jing Chen*, Likun Gong*, Lijiang Xuan*, Novel jatrophane diterpenoids from Euphorbia esula promotes lipid clearance by transcriptional regulation of PCSK9. Journal of Medicinal Chemistry, 2024, 67, 12055-12067

2. Qing Wang, Zhitao Wu, Chenyue Li, Guoqing Qin, Xianggang Hu, Pengju Guo, Aoxue Ding, Wenjing Xu, Wenqiong Wang*, Lijiang Xuan*, Haperforatones A-M, thirteen undescribed limonoids from Harrisonia perforata with anti-inflammatory activity. Bioorganic Chemistry, 2024, 151:107631

3. Aoxue Ding, Yiming Shan, Chenyue Li, Guoqing Qin, Tong Chen, Qing Wan, Xianggang Hu, Pengju Guo, Haijun Yu, Wenqiong Wang*, Lijiang Xuan*, Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities. Phytochemistry, 2024, 226:114219

4. Yao Zhu, Pengju Guo, Aoxue Ding, Liu Zheng, Gaoxiang Du, Tong Chen, Guoqing Qin, Xianggang Hu, Wenqiong Wang*, Lijiang Xuan*. Eighteen iridoids from the roots and rhizomes of Valeriana jatamansi and their protective effects against α-hemolysin. Phytochemistry, 219 (2024) 113962.

5. Pengju Guo, Tong Chen, Xianggang Hu, Yelin Duan, Liu Zheng, Gaoxiang Du, Qing Wang, Aoxue Ding, Guoqing Qin, Yihan Chen, Wenqiong Wang*, Qing Mu*, Lijiang Xuan*. Lindenane sesquiterpenoid dimers from Chloranthus japonicus improve LDL uptake by regulating PCSK9 and LDLR. Bioorganic Chemistry, 2023, 142: 106958

6. Kaiqing Lv, Hongying Ji, Gaoxiang Du, Shou Peng, Pengju Guo, Ge Wang, Yao Zhu, Qing Wang, Wenqiong Wang*, Lijiang Xuan*. Calysepins I-VII, hexasaccharide resin glycosides from Calystegia sepium and their cytotoxic evaluation. Journal of Natural Products, 2022, 85(5): 1294-1303.

7. Xianjing Zhang, Huihui Li, Wenqiong Wang, Tong Chen, Lijiang Xuan*, Lipid lowering activity of cucurbitacins isolated from Trichosanthes cucurmeroides and their synthetic derivatives. Journal of Natural Products, 2020, 83: 3536-3544

8. Mike Okweesi Aggrey, Huihui Li, Wenqiong Wang, Yiping Wang, Lijiang Xuan*, Indole alkaloid from Nauclea latifolia promotes LDL uptake in HepG2 cells by inhibiting PCSK9. Phytomedicine, 2019, 55: 264-268.

9. Huihui Li, Jun Li, Xianjing Zhang, Jiaomeng Li, Cong Xi, Wenqiong Wang, Youli Lu, Lijiang Xuan*, 23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9. Acta Pharmacolcgica Sinica, 2020, 41: 327-335

10. Yingluo Liu, Xiaoyu Zhou, Lijiang Xuan*. Magnesium lithospermate B ameliorates microcirculation perfusion in rats by promoting vascular NO production via activating the PI3K/AKT pathway. Acta Pharmacolcgica Sinica, 2019, 40: 1010-1018

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