Professor/Ph.D candidate supervisor, Principal Investigator
Natural Product Research Center
Personal Homepage
CONTACT
wmzhao@simm.ac.cn
021-50806052
201203
555 Zuchongzhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China. 201203
Dr. ZHAO has been devoted to the discovery of bioactive substances from Chinese herbal medicines for the purpose of providing scientific support for the usage of these natural medicines, as well as finding new drug leads. He has also been working on structural modification of bioactive natural products with the aim of finding leading compounds. Several bioactive natural and synthetic substances discovered in ZHAO’s lab are currently being investigated in preclinical stage or under further pharmacological research. He has published more than 100 research papers in peer-reviewed journals, and applied for more than 10 patents.
Education:
09/1984-07/1989 undergraduate student in Medicinal Chemistry, College of Pharmaceutical Sciences, Beijing Medical University.
09/1989-07/1992 M.S. candidate in Organic Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
09/1992-07/1995 Ph.D. candidate in Organic Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
10/1995-03/1997 Postdoctoral Research Associate, Institute of Pharmacognosy and Phytochemistry, University of Lausanne, Switzerland.
Work Experience:
09/1995–03/1997 Assistant Professor, Department of Phytochemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
04/1997–02/2002 Associate Professor, Department of Natural Product Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
03/2002-present Professor, Department of Natural Product Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
1. Isolation and structural elucidation of bioactive compounds from Chinese herbal medicines.
2. Structural modification of bioactive natural products.
Full Publication List
Selected Publications
1. Shao XC, Chen ZH, Liu SS, Wu F, Mu HY, Wei WH, Feng Y, Zuo JP, Zhang JQ, He SJ, Zhao WM. Minor immunosuppressive spiroorthoester group-containing pregnane glycosides from the root barks of Periploca sepium. Bioorg. Chem. 2021, 108, 104641.
2. Fu YF, Zhao WM. Polyesterified sesquiterpenoids from the seeds of Celastrus paniculatus as lifespan-extending agents for the nematode Caenorhabditis elegans. J. Nat. Prod. 2020, 83, 505-515.
3. Fu YF, Ding XY, Zhang XL, Shao XC, Zhao JH, Xu YC, Luo XM, Zhao WM. Diterpenoids from the root bark of Pinus massoniana and evaluation of their phosphodiesterase type 4D inhibitory activity. J. Nat. Prod. 2020, 83, 1229-1237.
4. Qin JJ, Fu YF, Chen X, Liu YT, Zhao JH, Zuo JP, Li YM, Zhu WL, Zhao WM. Celamonols A–D, four triterpenoid and catechin conjugates with immunosuppressive activities from the stems of Celastrus monospermus. Org. Chem. Front. 2019, 6, 3786-3792.
5. Fu YF, Wang W, Gong Q, Zhang HY, Zhao WM. Neuroprotective dihydro-β-agarofuran-type sesquiterpenes from the seeds of Euonymus maackii. J. Nat. Prod. 2019, 82, 3096-3103.
6. Wang LY, Qin JJ, Chen ZH, Zhou Y, Tang W, Zuo JP, Zhao WM. Absolute configuration of periplosides C and F and isolation of minor spiro-orthoester group-containing pregnane-type steroidal glycosides from Periploca sepium and their T-lymphocyte proliferation inhibitory activities. J. Nat. Prod. 2017, 80, 1102-1109.
7. Li JL, Gao ZB, Zhao WM. Identification and evaluation of antiepileptic activity of C-21 steroidal glycosides from the roots of Cynanchum wilfordii. J. Nat. Prod. 2016, 79, 89-97.
8. Gao L, Zhang RJ, Lan JF, Ning RN, Wu D, Chen D, Zhao WM. β-Dihydroagarofuran-type sesquiterpenes from the seeds of Celastrus monospermus and their lifespan-extending effects on the nematode Caenorhabditis elegans. J. Nat. Prod. 2016, 79, 3039-3046.
9. Li JL, Zhou J, Chen ZH, Guo SY, Li CQ, Zhao WM. Bioactive C-21 steroidal glycosides from the roots of Cynanchum otophyllum that suppress the seizure-like locomotor activity of zebrafish caused by pentylenetetrazole. J. Nat. Prod. 2015, 78, 1548-1555.
10. Ning RN, Lei Y, Liu SZ, Wang HM, Zhang RJ, Wang W, Zhu YD, Zhang HY, Zhao WM. Natural β-dihydroagarofuran-type sesquiterpenoids as cognition-enhancing and neuroprotective agents from medicinal plants of the genus Celastrus. J. Nat. Prod. 2015, 78, 2175-2186.
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