CHEN Tiegen
Principal Investigator
Small-Molecule Drug Research Center
Personal Homepage
CONTACT
chentiegen@simm.ac.cn
0760-85281952-8517
Biography
Tie-Gen Chen, Ph.D., Principal investigator of Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Zhongshan Institute for Drug Discovery, the Institutes of Drug Discovery and Development, CAS. Dr. Chen received his BSc in chemistry from Sichuan University in 2009. He obtained his PhD at Shanghai Institute of Organic Chemistry (SIOC) under the supervision of Prof. Li-Xin Dai and Prof. Xue-Long Hou in 2014. In 2016, he joined the laboratory of Prof. Phil S. Baran as a postdoctoral fellow at The Scripps Research Institute (TSRI). Since September 2020, Dr. Chen has worked at Shanghai Institute of Materia Medica, Chinese Academy of Sciences. His current research interests are mainly focused on the innovative radical chemistry and medicinal chemistry.
Education:
2016.02 - 2020.01 Postdoctoral Research Fellow, The Scripps Research Institute (TSRI),USA
2009.09 - 2014.12 Ph.D., Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences
2005.09 - 2009.07 B.S., Department of Chemistry, Sichuan University
Professional Experience:
2020.09 - Present Professor, Shanghai Institute of Materia Medica, CAS and Zhongshan Institute for Drug Discovery, the Institutes of Drug Discovery and Development, CAS.
2015.06 - 2016.01 Senior Scientist I, WuXi AppTec Co. LTD. Shanghai, China
2015.01 – 2015.05 Research Assistant, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences
Research Directions
1.Novel synthetic methodologies (radical chemistry);
2.Total synthesis and structural modification of natural products;
3.Discovery of lead compounds and candidate compounds;
4.Bioactive small molecules library.
Grants & Research Projects
Achievements
1.A new protocol has been devised to enable the coupling of general tertiary systems using nickel catalysis. The scope of this operationally simple method is broad, and it can be used to simplify the synthesis of medicinally relevant motifs bearing quaternary centers.
2.The strategic combination of classic cycloaddition chemistry with newly emerging radical C–C coupling as exemplified here offers a powerful way to repurpose the most classic skeleton-building reactions of organic synthesis to simplify the enantioselective preparation of building blocks, natural products, and medicines. [Building C(sp3)-rich complexity by combining cycloaddition and C–C cross-coupling reactions. Nature 2018, 560, 350.]
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Social Titles
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Awards & Honors
2009 Outstanding Graduates Award, Sichuan University.
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Pubilcations
Selected Publications
1. Quaternary Centers via Ni-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and Aryl Zinc Reagents. Chen, T. -G.; Zhang, H.; Mykhailiuk, P. K.; Merchant, R. R.; Smith, C. A.; Qin, T.; Baran, P. S. Angew. Chem. Int. Ed. 2019, 58, 2454.
2. Building C(sp3)-rich complexity by combining cycloaddition and C–C cross-coupling reactions, Chen, T.-G.#; Barton, L. S.#; Lin, Y.#; Tsien, J.; Kossler, D.; Bastida, I.; Asai, S.; Bi, C.; Chen, J. S.; Shan, M.; Fang, H.; Fang, F. G.; Choi, H.; Hawkins, L.; Qin, T.; Baran, P. S. Nature 2018, 560, 350. (#co-first author)
3. Redox-Active Esters in Fe-catalyzed C-C Coupling, Toriyama, F.#; Cornella, J.#; Wimmer, L.; Chen, T.-G.; Dixon, D. D.; Creech, G.; Baran, P. S. J. Am. Chem. Soc. 2016, 138, 11132.
4. Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids, Wang, J.; Qin, T.; Chen, T.-G.; Wimmer, L.; Edwards, J. T.; Cornella, J.; Vokits, B.; Shaw, S. A.; Baran, P. S. Angew. Chem. Int. Ed. 2016, 55, 9676.
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