Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

Dr. Zhen Cheng is Professor and the Director of the Molecular Imaging Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences. He is the Fellow of RSC and SPIE. He was also a faculty member of the Molecular Imaging Program at Stanford University from 2007 to 2021. His research has focused on the development of molecular imaging techniques and radiopharmaceuticals for the early detection and therapy of cancer. Dr. Cheng’s group has developed numerous multimodal imaging probes (PET, SPECT, optical, photoacoustic, and MRI), and published more than 300 articles. He is the Associate Editor of Nanomedicine: Nanotechnology, Biology, and Medicine and on the editorial board of Clinical Cancer Research, EJNMMI, Bioconjugate Chemistry, Amino Acids and so on.

Education

2001.09-2003.08 Postdoc, Radiology, Harvard Medical School

1997.09-2001.07 PhD, Radiopharmaceutical Chemistry, University of Missouri – Columbia

1994.09-1997.07 MS, Radiopharmaceutical Chemistry, China Institute of Atomic Energy

1990.09-1994.07 BS, Chemistry, Sichuan University

Work Experience

2021 - Present Professor and Director, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

2014 - 2021 Associate Professor, Department of Radiology, School of Medicine, Stanford University

2007 - 2014 Assistant Professor, Department of Radiology, School of Medicine, Stanford University

2003 - 2007 Research Scientist, Department of Radiology, School of Medicine, Stanford University

Research Directions

1. Molecular imaging and multimodal imaging probes

2. Radiopharmaceutical research

3. Nanomedicine

Grants & Research Projects

Achievements

1.Successfully realizing the clinical translation of 4 PET probes;

2.Exploratory study of small molecular probes for NIR-II imaging and clinical translation of NIR-II imaging technology;

3.Exploratory study of Cherenkov imaging;

4.Research on bioinspired nanomaterials - melanin nanoparticles

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Social Titles

1.Member of the Academic Committee of the Key Laboratory of Radiopharmaceutical Research and Evaluation, National Medical Products Administration, 2021-present;

2.Standing Committee Member, Radiopharmaceutical Branch, Chinese Nuclear Society, 2018-present;

3.President, Chinese American Society of Nuclear Medicine and Molecular Imaging, 2015-2017;

4.President-elect and Board of Directors, Chinese American Society of Nuclear Medicine and Molecular Imaging, 2013-2015;

5.Board Directors of the Radiopharmaceutical Science Council, the Society of Nuclear Medicine and Molecular Imaging, 2012-2014;

6.Associate Editor, Nanomedicine: Nanotechnology, Biology and Medicine, 2017-present;

7.Assocaite Editor, Frontiers in Physics-Medical Physics and Imaging, 2014- present;

8.Editorial Board, Clinical Cancer Research; EJNMMI; Bioconjugate Chemistry; Amino Acids; Anti-Cancer Agents in Medicinal Chemistry; Biophysics Reports; Diagnostics; Frontiers in Nuclear Medicine; Quantitative Imaging in Medicine and Surgery

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Awards & Honors

1. Fellow of the Society of Photo-Optical Instrumentation Engineers, FSPIE

2. Fellow of Royal Society of Chemistry, FRSC

3. Top 5% of highly cited authors with Royal Society of Chemistry journals, 2020

4. World’s Top 2% Scientists, 2020

5. Top 5% of highly cited authors in General chemistry portfolio of journals, Royal Society of Chemistry, 2019

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Pubilcations

Full Publication List

Selected Publications

1.Chang B, Li D, Ren Y, Qu C, Shi X, Liu R, Liu H, Tian J, Hu Z*, Sun T*, Cheng Z*. A phosphorescent probe for in vivo imaging in the second near-infrared window. Nature Biomedical Engineering. 2022, 6(5):629-639. PMID: 34385694.

2.Chang B,* Zhang L, Wu S, Sun Z*, Cheng Z*. Engineering single-atom catalysts toward biomedical applications. Chemical Society Reviews, 2022,51(9):3688-3734. PMID: 35420077.

3.Ji A, Lou H, Qu C, Lu W, Hao Y, Li J, Wu Y, Chang T, Chen H*, Cheng Z*. Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance. Nature Communications. 2022. in press.

4.Chen H, Shou K, Chen S, Qu C, Wang Z, Jiang L, Zhu M, Ding B, Qian K, Ji A, Lou H, Tong L, Hsu A, Wang Y, Felsher DW, Hu Z*, Tian J*, Cheng Z*. Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging. Advanced Materials. 2021;e2006902. PMID: 33709533.

5.Hu Z, Fang C, Li B, Zhang Z, Cao C, Cai M, Su S, Sun X, Shi X, Li C, Zhou T, Zhang Y, Chi C, He P, Xia X, Chen Y, Gambhir SS*, Cheng Z*, Tian J*. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows. Nature Biomedical Engineering. 2020, 4, 259-271. PMID:31873212

6.Liang J#, Wang H#, Ding W, Huang J, Zhou X, Wang H, Dong X, Li G, Chen E, Zhou F, Fan H, Xia J, Shen B, Cai D, Lan P, Jiang H, Ling J, Cheng Z*, Liu X*, Sun J*. Nanoparticle-Enhanced Chemo-immunotherapy to Trigger Robust Antitumor Immunity. Science Advances, 2020, 6(35), eabc3646.

7.Ma X, Wang S, Wang S, Liu D, Zhao X, Chen H, Kang F, Li G, Yang W, Wang J*, Cheng Z*. Biodistribution, Radiation Dosimetry, and Clinical Application of a Melanin Targeted PET Probe 18F-P3BZA in Patients. Journal of Nuclear Medicine. 2019; 60(1):16-22. PMID:29853651. [the best translational article], highlighted by JNM.

8.Sun X, Xiao Z, Chen G, Han Z, Liu Y, Zhang C, Sun Y, Song Y, Wang K, Fang F, Wang X, Lin Y, Xu L, Shao L, Li J, Cheng Z*, Gambhir SS*, Shen B*. A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management. Science Translational Medicine. 2018;10(431). pii: eaan8840. PMID: 29515002.

9.He S, Song J*, Qu J*, Cheng Z.* Crucial Breakthrough of Second Near-infrared Biological Window Fluorophores: Design and Synthesis toward Multimodal Imaging and Theranostics. Chemical Society Review, 2018, 47(12): 4258 – 4278. PMID: 29725670.

10.Antaris AL, Chen H, Diao S, Ma Z, Zhang Z, Zhu S, Wang J, Lozano AX, Fan Q, Chew L, Zhu M, Cheng K, Hong X*, Dai H*, Cheng Z*. A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging. Nature Communications. 2017;8:15269. doi: 10.1038/ncomms15269. PMID:28524850.

11.Antaris AL, Chen H, Cheng K, Sun Y, Hong G, Qu C, Diao S, Deng Z, Hu X, Zhang B, Zhang X, Yaghi OK, Alamparambil ZR, Hong X*, Cheng Z*, Dai H*. A small-molecule dye for NIR-II imaging. Nature Materials. 2016;15(2):235-42. PMID: 26595119.

12.Fan Q, Cheng K, Hu X, Ma X, Zhang R, Yang M, Lu X, Xing L, Huang W, Cheng Z.* Transferring Biomarker into Molecular Probe: Melanin Nanoparticle as a Naturally Active Platform for Multimodality Imaging. Journal of the American Chemical Society. 2014, 136(43):15185-94. PMID: 25292385. (Highlighted in the Spotlights of JACS)

13.Cheng K, Kothapalli SR, Liu H, Koh AL, Jokerst JV, Jiang H, Yang M, Li J, Levi J, Wu JC, Gambhir SS, Cheng Z.* Construction and Validation of Nano Gold Tripods for Molecular Imaging of Living Subjects. Journal of the American Chemical Society. 2014; 136(9):3560-3571. PMID: 24495038. (Highlighted in the Spotlights of JACS)

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