LI Yaping
Principal Investigator
Center of Pharmaceutics
Personal Homepage
CONTACT
ypli@simm.ac.cn
+86-21-68077894
201203
Room 1515, Building 1, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong Shanghai 201203
Biography
Education:
1998 – 2001 Ph.D. School of Pharmacy, Fudan University, China
1993 – 1996 M.S. Shenyang Pharmaceutical University, China
1984 – 1987 Hubei Pharmaceutical Industry School, China
Work Experience:
2015 – Now Professor, Director, Yantai Institute of Pharmaceutical Science (Yantai Branch of SIMM, CAS)
2007 – Now Professor, Director, Center of Pharmaceutics, SIMM, CAS
2006 – Now Professor, Principal Investigator, SIMM, CAS
2003 Visiting Scholar, University of California, San Francisco (UCSF), USA
2002 – 2006 Associate Professor, Principal Investigator, SIMM, CAS
2001 – 2002 Postdoc, Ludwid Maximilian University (LMU), Germany
1996 – 2002 Assistant Professor, Principal Investigator, SIMM, CAS
1991 – 1993 Factory deputy director, Anlu Pharmaceutical Factory, Hubei
1987 – 1991 Section chief, Director, Anlu Pharmaceutical Factory, Hubei
Research Directions
1. Nanochemistry
2. Pharmaceutics
3. Drug delivery
4. Biomaterials
5. Nanomedicine
6. Medicinal chemistry
Grants & Research Projects
Projects supported by National Natural Science Foundation of China (NSFC)
1. 2022-2026, NSFC, Key Project, PI, “Biomimetic nanovesicle targeting tumors enhance epigenetic anticancer efficacy” (32130058).
2. 2020-2024, NSFC, Key Project, PI, “The improvement of tumor immune checkpoint blocking therapy effect by a three element synergistic enzyme sensitive nanodrug delivery system” (31930066).
3. 2017-2021, NSFC, Major Project, PI, “The efficacy and safety of efficient delivery systems for biomacromolecule drugs” (81690265).
4. 2017-2021, NSFC, Key Project, PI, “Targeted nano-delivery system based on erythrocyte membrane against lung metastasis of breast cancer” (81630052).
5. 2016-2021, NSFC, the Innovation Research Group, PI, “A novel delivery system based on nanotechnology for anticancer drugs” (81521005).
6. 2013-2017, NSFC, Key Project, PI, “New cationic poly(β-Amino ester)/RNA self-assembled nanoparticles for targeted therapy of Tumor” (81230029).
7. 2010-2013, NSFC, Distinguished Young Scholar, PI, “Drug delivery system and molecular pharmaceutics” (30925041).
8. 2009-2011, NSFC, General Project, PI, “Cationic Click Polymer/DNA Self assembled Nanoparticles” (30873169).
9. 2006-2008, NSFC, General Project, PI, “DNA-polyphosphazene derivative nanoparticles with high transfection efficiency” (30572259).
10. 2004-2006, NSFC, General Project, PI, “Active targeting stealth nanoparticles as non-viral gene carriers” (30371691).
Projects supported by Ministry of Science and Technology (MOST) of China
11. 2023-2027, MOST, National Key R&D Program, Chief Scientist, “Key technologies for targeted delivery of nucleic acid drugs in vivo” (2022YFC3401400).
12. 2010-2014, MOST, 973 Program, Chief Scientist, “Basic research on the application of new drug formulations based on nanotechnology to improve tumor treatment effectiveness” (2010CB934000).
13. 2005-2007, MOST, 973 Program, Academic backbone, “Nanostructures and functionalization based on biomolecule induced assembly” (2005CB724700).
14. 2004-2009, MOST, 973 Program, Project 2 leader, “Novel gene non-viral vectors” (2004CB518802).
Projects supported by Chinese Academy of Sciences (CAS)
15. 2020-2021, CAS, Key project of the STS network program, PI, “R&D of new reduction sensitive high efficiency and low toxicity oxaliplatin nanomicelles” (KFJ-STS-ZDTP-081).
16. 2019-2022, CAS, Key project for foreign cooperation, PI, “A prodrug co-delivery nano DDS for regulating the tumor immune microenvironment to improve the efficacy of tumor immunotherapy” (KYSB20190013).
17. 2018-2020, CAS, Leading strategy A: Personalized drug, Sub project leader, “Key technologies for personalized drug delivery” (XDA12050307).
18. 2016-2020, CAS, Advanced Science Key Research Program of CAS - middle-aged outstanding scientists, PI, “Anti lung metastasis of breast cancer with biomimetic nano drug based on erythrocyte membrane” (QYZDJ-SSW-SMC020).
19. 2013-2018, CAS, Leading strategy A: Nano, Sub project leader, “Industrialization technology of nanodrugs” (XDA09030304).
20. 2010-2011, CAS, Important directional project, PI, “Novel efficient and multifunctional delivery system for siRNA” (KSCX2-YW-R-193).
21. 2006-2009, CAS, Important directional project, Academic backbone, “Targeted gene therapy for cancer” (KSCX2-YW-R-09).
22. 2005-2007, CAS, Important directional projects, Project 1 leader, “Basic research on nanobiomedicine and devices” (kjcx2-sw-h12-01).
Projects supported by Shanghai
23. 2024-2027, Action Plan for Technology Innovation, PI, “AI empowered small RNA drug lymphatic targeted delivery for tumor immunotherapy” (24J22800600)
24. 2019-2021, Action Plan for Technology Innovation, PI, “Preclinical study of PEG oxaliplatin bonded prodrug for injection” (19431900800).
25. 2012-2015, Action Plan for Technology Innovation, PI, “The anti-tumor metastasis effect of reducing responsive tween 85-LPEI/nucleic acid complex nanoparticles” (12nm0501300).
26. 2011-2014, Action Plan for Technology Innovation, PI, “New cationic polymerization (β-aminoester) derivatives/nucleic acid nanocomposite to reduce tumor drug resistance” (11nm0505900).
27. 2011-2013, Outstanding Academic Leaders Program, PI, “Anti lung metastasis of breast cancer by reduction responsive poly (β-aminoester)/siRNA nanocomposite” (11XD1406200).
28. 2010-2012, Action Plan for Technology Innovation, PI, “Improving the bioavailability of insoluble drug daidzein by nanotechnology” (1052nm06300).
29. 2008-2010, Action Plan for Technology Innovation, PI, “Gene nanocarriers based on cationic click polymers” (0852nm05700).
30. 2008-2010, Key biomedical projects, PI, “Key technologies for industrialization of non-patented insoluble drugs” (074319117).
Projects supported by Shandong
31. 2023-2025, Department of Science and Technology, Shandong Provincial Laboratory Special Project, PI, “Research on candidate drugs for anti-tumor targeted peptide conjugated drugs (PDC)” (SYS22A208)
32. 2023-2025, Department of Science and Technology, Shandong Provincial Laboratory Special Project, PI, “R&D of peptide coupled molecular self-assembled hydrogel” (SYS22B238)
33. 2023-2025, Department of Science and Technology, Shandong Provincial Laboratory Special Project, PI, “R&D of a nucleic acid drug delivery system for in vivo compilation of chimeric antigen receptors” (SYS22B237)
34. 2023-2025, Department of Science and Technology, Shandong Provincial Laboratory Special Project, PI, “R&D of Research on tumor vaccines empowered by artificial intelligence” (SYS22B233)
35. 2021-2023, China Academy of Sciences Bohai (Yantai) Pharmaceutical Advanced Research Institute, Special Project, PI, “Screening, optimization, and preclinical early evaluation of candidate new drugs for anti-tumor targeted peptide conjugated drugs (PDC)” (LX211007)
36. 2021-2023, China Academy of Sciences Bohai (Yantai) Pharmaceutical Advanced Research Institute, Special Project, PI, “New liver targeted THR- β Development of agonist prodrug against NASH” (LX211003)
37. 2021-2023, China Academy of Sciences Bohai (Yantai) Pharmaceutical Advanced Research Institute, Special Project, PI, “Synthesis and evaluation of two long-acting prodrug derivatives for chronic diseases” (LX211002)
38. 2021-2023, China Academy of Sciences Bohai (Yantai) Pharmaceutical Advanced Research Institute, Special Project, PI, “Study on long-acting siRNA candidate new drugs targeting angiotensinogen” (LX211001)
39. 2021-2023, China Academy of Sciences Bohai (Yantai) Pharmaceutical Advanced Research Institute, Special Project, PI, “Study on injectable poly (caprolactone) microspheres as facial fillers” (LX215003)
40. 2021-2023, China Academy of Sciences Bohai (Yantai) Pharmaceutical Advanced Research Institute, Special Project, PI, “Preclinical study of celecoxib nano freeze-dried disintegrating tablets” (LX213001)
41. 2021-2023, China Academy of Sciences Bohai (Yantai) Pharmaceutical Advanced Research Institute, Special Project, PI, “Preclinical study of a new drug SN38 composite liposome” (LX212001)
42. 2019-2024, Department of Science and Technology, Provincial Natural Science Foundation (Major Basic Research), PI, “Basic research on the application of enzyme sensitive nanocarrier system to enhance the therapeutic effect of tumor immune checkpoint blockade” (ZR2019ZD25)
43. 2016-2018, Department of Science and Technology, Development and Construction Project of Shandong Peninsula National Independent Innovation Demonstration Zone, PI, “Preclinical studies on reducing responsive release of amphiphilic polymer drugs” (ZCQ16101)
Achievements
1. Proposed a new concept of designing anticancer drug carriers with integrated "precise delivery + intelligent drug release", achieving a significant breakthrough in overcoming tumor immunotherapy tolerance. He clarifies the physical pharmaceutical factors of nanocarriers that affect drug delivery in drug-resistant tumors, discover and systematically reveal the mechanism of nanodrugs to overcome tumor chemotherapy resistance, pioneer the biomimetic T-cell nanovesicle to effectively overcome the immune tolerance generated by epigenetic therapy, and create the photodynamic driven nanodrug delivery system to enhance the effect of tumor immune checkpoint blockade.
2. Pioneered a new direction for anti-tumor metastasis of nanomedicine, and has created new anti-cancer drug formulations with remarkable “superior efficacy”. He pioneers the first Ly6Chi monocyte-based nano-preparation that targets triple negative breast cancer and lung metastasis foci; Propose and confirm a new idea of targeted infiltration of tumors and metastatic lesions through the "tumor-homing effect of macrophage", and pioneer a macrophage membrane targeted biomimetic drug delivery system of DM1, realizing tumor metastatic lesion-targeted drug delivery.
3. Invented new technologies such as secondary composite lipidation to solve the "bottleneck" problem of low bioavailability of water insoluble drugs and poor druggability of drug candidates. Reveal the process, pathway and mechanism of nanodrugs in improving the oral absorption of insoluble drugs, increase the oral bioavailability of 19 insoluble drugs, improve efficacy, or generates new effects. For the first time, a formulation solution has been proposed to improve the druggability of candidate new drugs, solving the key challenges of druggability for 23 candidate new drugs.
4. Authored over 280 high-impact publications (173 papers with IF>10) in the TOP journals such as Nat Nanotech, Sci Immunol, Adv Mater and Nat Commun, et a, with over 23000 citations, 24 ESI Highly Cited Papers, and an H-factor of 84. He is a highly cited scientist in Elsevier & Clarivate, and TOP 5 in the China TOP 100 Academic Influence of Pharmacy Specialists list (Global Scholars Database) since 2021. He has given more than 200 plenary/invited lectures in international/national conferences.
5. Led the R&D of over 50 pharmaceutical preparations, 23 of which are in clinical uses, with 16 into clinical trials, 10 in pre-clinical stages. He has also established 9 national drug standards and authorized 82 patents.
6. Cultivated 170 young talents and graduate students, 4 doctoral students won excellent doctoral theses from the CAS, 1 person won the Special Award of the Dean of the CAS, 3 people won the Excellent Award of the Dean, 6 doctoral students won the Three Good Student Model of the CAS, and 12 doctoral students won outstanding graduates from the CAS or Shanghai.
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Social Titles
2023 – Now Editorial Board Member, Pharmaceutics
2022 – Now Member of Council, Chinese Anti Cancer Association (CACA)
2021 – 2024 Chairman, Nano-oncology Professional Committee of CACA
2021 – Now Editorial Board Member, Exploration
2019 – Now Chairman (2020)/Board Member, China Local Chapter, Controlled Release Society (CRS)
2017 –Now Member of Council, the Chinese Pharmaceutical Association (CPA)
2017 – 2021 Chairman-designate of the Nano-oncolog Professional Committee of CACA
2015 – 2024 Vice Chairman of the Nanomedicine Professional Committee of the CPA
2014 – Now Editorial Board Member, Asian Journal of Pharmaceutical Sciences (AJPS)
2013 – Now Standing Committee Member, Gene Therapy Branch, China Medical Biotechnology Association
2012 – 2017 Vice Chairman of the Nano-oncolog Professional Committee of CACA
2011 – Now Editorial Board Member, Acta Pharmaceutica Sinica B (APS B)
2011 – 2022 Standing Committee Member, the Nanotoxicology Professional
Committee of the Chinese Society of Toxicology
2011 – 2024 Vice Chairman of the Pharmaceutics Professional Committee of Shanghai Pharmaceutical Association
2011– Now Member of Council, Shanghai Pharmaceutical Association
2010 – Now Director of the Nanobiopharmaceutical Industry Technology Innovation Strategic Alliance
2010 – Now Member of Council, Chinese Local Chapter, CRS
2006 – 2023 Member/Senior Member of the Pharmaceutics Professional Committee of the
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Awards & Honors
2024 – Special Contribution Award of the 18th China Pharmaceutical Development Award
2024 – Fellow of International Association of Advanced Materials (FIAAM)
2024 – The Fellow of the Royal Society of Chemistry (FRSC)
2023 – The TOP 5 of the Top 100 Chinese Pharmaceutical Experts with the highest Academic Influence (Global Scholars Database)
2023 – Shanghai Pudong New Area "Pearl Leading Talents"
2023 – The APSB 2023 Best Reviewer Award
2022 – First Prize of Shanghai Science and Technology Progress Award
2022 – 17th Shanghai Science and Technology Elite Award
2022 – Wu Jieping Pharmaceutical Innovation Award
2022 – Chief Scientist of National Key R&D Program
2021 – Now, Highly Cited Scientist (Elsevier & Clarivate)
2021 – 2022 The TOP 4 of the Top 100 Chinese Pharmaceutical Experts with the highest Academic Influence (Global Scholars Database)
2021 – 2024 World Top 2% Scientist (Released by Stanford University)
2020 – Second Prize of National Natural Science Award
2020 – First Prize of Science and Technology Award of Chinese Pharmaceutical Association (CPA)
2019 – Mount Taishan Scholar Distinguished Expert
2018 – Wu Jieping-Paul Janssen Medical & Pharmaceutical Award
2018 – CPA-Yiling Biomedical Innovation Award
2017 – National Leading Talent of Scientific Innovation
2016 – Leader of the Innovation Team in Key Areas of the Ministry of Science and Technology (MOST)
2016 – Experts with Special Government Subsidies from the State Council
2015 – Academic leader of the Innovation Research Group of the National Natural Science Foundation of China (NSFC)
2015 – First Prize of Science and Technology Award of CPA
2015 – Distinguished Young-Middle Age Scientists in China
2015 – Distinguished Professor in CAS
2015 – The National Hundred and Ten Million Talents Project
2013 – First Prize of Science and Technology Award of Shanghai Pharmaceutical Association
2013 – Wu-xi Life & Chemistry Award
2011 – The Outstanding Academic Leader of Shanghai
2010 – Winners of the "Hundred Talents Program" of CAS
2010 – The Leading Talent of Shanghai
2010 – Zhu Liyuehua Award for Excellent Teachers, CAS
2010/2011/2012/2014 – Excellent Supervisor, CAS
2009 – First Prize of Science and Technology Award of Shanghai Pharmaceutical Association
2009 – Winner of the National Science Fund for Distinguished Young Scholars
2009 – Chief Scientist of the National Major Scientific Research Program (973)
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Pubilcations
Full Publication List
Selected Publications
2025
1. Wenzhe Yi, Shuangshuang Hu, Xindi Qian, Wenlu Yan, Yaping Li*. Synthetic biology-based engineering cells for drug delivery. Exploration, 2025, In press
2024
2. Ying Cai, Tiantian Xu, Binyu Zhu, Junfan Chen, Linyang Jiang, Xiaoting Shan, Rong Rong, Yao Li, Yang Yu, Xin Gao, Helen He Zhu, Lu Zhang*, Pengcheng Zhang*, Yaping Li*. Conformation influences biological fates of peptide-based nanofilaments by modulating protein adsorption and interfilament entanglement. Adv Mater 2024, 2409130
3. Wenlu Yan, Ying Cao, Shanshan Xu, Yu Li, Ting Wu, Wenhui Yuan, Qi Yin *, Yaping Li*. Personalized multi-epitope nanovaccine unlocks B cell-mediated multiple pathways of antitumor immunity. Adv Mater 2024, 2411361
4. Ying Cai, Binyu Zhu, Xiaoting Shan, Lingli Zhou, Xujie Sun, Anqi Xia, Binhao Wu, Yang Yu, Helen He Zhu, Pengcheng Zhang*, Yaping Li*. Inhibiting endothelial cell-mediated T lymphocyte apoptosis with integrin-targeting peptide-drug conjugate filaments for chemoimmunotherapy of triple-negative breast cancer. Adv Mater 2024, 36, 2306676
5. Xujie Sun, Xiaoting Shan, Binyu Zhu, Ying Cai, Zongyan He, Lingli Zhou, Lixuan Yin, Yiran Liu, Kaiyue Liu, Tian Zhang, Ning Yang, Yaping Li* and Tianqun Lang*. 5-fluorouracil loaded prebiotic-probiotic liposomes: a potential strategy for modulating gut microbiota in colorectal cancer chemotherapy. Adv Healthc Mater 2024, 2403587
6. Yihui Zhai, Wen Zhang, Jinming Wang, Ying Kong, Rong Rong, Tianqun Lang, Chao Zheng, Yanke Wang, Yang Yu, Helen He Zhu, Ying Cai*, Pengcheng Zhang*, Yaping Li*. Interleukin 15-presenting nanovesicles with doxorubicin-loaded ferritin cores for cancer immunochemotherapy. Adv Sci 2024, 2409194
7. Ying Cao, Wenlu Yan, Wenzhe Yi, Qi Yin*, Yaping Li*. Bioengineered therapeutic systems for improving antitumor immunity. Natl Sci Rev 2024, nwae404
8. Xiaoting Shan, Ying Cai, Binyu Zhu, Lingli Zhou, Xujie Sun, Xiaoxuan Xu, Qi Yin, Dangge Wang*, Yaping Li*. Rational strategies for improving the efficiency of design and discovery of nanomedicines. Nat Commun 2024, 15, 9990
9. Xiaochen Liu, Zhiwen Zhao, Xiaoxuan Xu, Wenzhe Yi, Dan Yan, Dangge Wang*, Yaping Li*. Mobilizing STING pathway via a cationic liposome to enhance doxorubicin-induced antitumor immunity. Adv Funct Mater 2024, 2416406
10. Yao Wu, Yongping Li, Honglei Xie, Yichen Zhang, Xinyue Bao, Xianyi Sha, Jingyuan Wen, Yaping Li*, Zhiwen Zhang*. Biomimetic nanoreactor of catalase and nitric oxide enhance peroxynitrite generation for radiosensitization. Nano Today 2024, 59, 102519
11. Chao Zheng, Linyang Jiang, Xiang Gong, Wen Zhang, Chen Jiang*, Hao Wang*, Pengcheng Zhang*, Yaping Li*. Cabozantinib-encapsulated and maytansine-conjugated high-density lipoprotein for immunotherapy in colorectal cancer. J Control Release 2024, 376, 138-148
12. Jie Li, Yao Wu, Yongping Li, Hongbo Zhu, Zhiwen Zhang*, Yaping Li*. Glutathione-disrupting nanotherapeutics potentiate ferroptosis for treating luminal androgen receptor-positive triple negative breast cancer. ACS Nano 2024, 18, 26585-26599
13. Wenlu Yan, Ying Cao, Qi Yin*, Yaping Li*. Biomimetic nucleic acid drug delivery systems for relieving tumor immunosuppressive microenvironment. Pharmaceutics 2024, 16, 1028
14. Jue Wang, Xiangshi Sun, Zhiwen Zhao, Guanru Wang, Dangge Wang*, Yaping Li*. Confined copper depletion via a hydrogel platform for reversing dabrafenib/cetuximab resistance in BRAFV600E-mutant colorectal cancer. J Control Release 2024, 375, 643-653
15. Runqi Zhu, Wenhui Yuan, Xujie Sun, Wenlu Yan, Ting Wu, Anqi Xia, Yu Li, Qi Yin*, Yaping Li*. Inulin-based nanoparticle modulates gut microbiota and immune microenvironment for improving colorectal cancer treatment. Adv Funct Mater 2024, 34, 2407685
16. Chao Zheng, Wen Zhang, Xiang Gong, Fengqin Xiong, Linyang Jiang, Yuan Zhang, Helen He Zhu, Hao Wang*, Chen Jiang*, Yaping Li*, Pengcheng Zhang*. Chemical conjugation mitigates immunotoxicity of chemotherapy via reducing receptor-mediated drug leakage from lipid nanoparticles. Sci Adv 2024, 10, eadk9996
17. Yao Wu, Yongping Li, Zixin Hu, Yuan Li, Shixuan Zhang, Xinyue Bao, Yu Zhou, Yuan Gao, Yaping Li*, Zhiwen Zhang*. Extracellular matrix-trapped bioinspired lipoprotein prolongs tumor retention to potentiate antitumor immunity. Adv Mater. 2024, 36, 2310982
18. Wen Zhang, Yihui Zhai, Ying Cai, Binyu Zhu, Yunxuan Jiang, Xiang Gong, Rong Rong, Helen He Zhu, Hao Wang*, Yaping Li*, Pengcheng Zhang*. Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membrane-decorated nanoparticles. Acta Pharm Sin B 2024, 14, 3218-3231
19. Xiang Gong, Chao Zheng, Ying Cai, Wen Zhang, Binyu Zhu, Rong Rong, Yuan Zhang, Jian Wang*, Yaping Li*, Pengcheng Zhang*. Adenosine-modulating synthetic high-density lipoprotein for chemoimmunotherapy of triple-negative breast cancer. J Control Release 2024, 367, 637-648
2023
20. Wenlu Yan, Yu Li, Yiting Zou, Runqi Zhu, Ting Wu, Xujie Sun, Wenhui Yuan, Tianqun Lang*, Qi Yin*, Yaping Li*. Breaking tumor immunosuppressive network by regulating multiple nodes with triadic drug delivery nanoparticle. ACS Nano 2023,17, 17826-17844
21. Wenlu Yan, Yu Li, Yiting Zou, Runqi Zhu, Ting Wu, Wenhui Yuan, Tianqun Lang*, Yaping Li*, Qi Yin*. Co-delivering irinotecan and imiquimod by pH-responsive micelle amplifies anti-tumor immunity against colorectal cancer. Int J Pharm 2023, 648, 123583
22. Lei Zhou, Wenzhe Yi, Zehong Zhang, Xiaoting Shan, Zitong Zhao, Xiangshi Sun,
Jue Wang, Hao Wang, Hualiang Jiang, Mingyue Zheng*, Dangge Wang*, Yaping
Li*. STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy. Natl Sci Rev 2023, 10, nwad214
23. Xinyue Zhang, Jie Li, Rong Rong, Xindi Qian, Minghui Zhang, Qingmin Yang, Guanru Wang, Yaping Li*, Zhiwen Zhang*. Enhancing the oral bioavailability of amisupiride with solid nanodispersion. J Drug Deliv Sci Tec 2023, 86, 104635
24. Fengqin Xiong, Wen Zhang, Chao Zheng, Xiang Gong, Yuan Zhang, Hao Wang*,
Pengcheng Zhang*, Yaping Li*. Gemcitabine-loaded synthetic high-density lipoprotein preferentially eradicates hepatic monocyte-derived macrophages in mouse liver with colorectal cancer metastases. Acta Pharmacol Sin 2023, 44, 2331-2341
25. Tianqun Lang, Runqi Zhu, Xiao Zhu, Wenlu Yan, Yu Li, Yihui Zhai, Ting Wu, Xin Huang, Qi Yin*, Yaping Li*. Combining gut microbiota modulation and chemotherapy by capecitabine-loaded prebiotic nanoparticle improves colorectal cancer therapy. Nat Commun 2023, 14, 4746
26. Zhiwen Zhao, Dangge Wang*, Yaping Li*. Versatile biomimetic nanomedicine for treating cancer and inflammation disease. Med Rev 2023, 3, 123-151
27. Wenzhe Yi, Dan Yan, Dangge Wang*, Yaping Li*. Smart drug delivery systems to overcome drug resistance in cancer immunotherapy. Cancer Biol Med 2023, 20, 248-267
28. Xiaoxuan Xu, Xindi Qian, Qiang Wang, Yao Wu, Jiaoying Wang, Jie Li, Yaping Li, Zhiwen Zhang*. Spatial-drug-laden protease-activatable M1 macrophage system targets lung metastasis and potentiates antitumor immunity. ACS Nano 2023, 17, 5354-5372
29. Xiangshi Sun, Xiaoxuan Xu, Jue Wang, Xinyue Zhang, Zitong Zhao, Xiaochen Liu, Guanru Wang, Lesheng Teng, Xia Chen*, Dangge Wang*, Yaping Li*. Acid-switchable nanoparticles induce self-adaptive aggregation for enhancing antitumor immunity of natural killer cells. Acta Pharm Sin B 2023, 13, 3093-3105
30. Yao Wu, Honglei Xie, Yongping Li, Xinyue Bao, Guoliang Lu, Jingyuan Wen Yuan Gao*, Yaping Li*, Zhiwen Zhang*. Nitric oxide-loaded bioinspired lipoprotein normalizes tumor vessels to improve intratumor delivery and chemotherapy of albumin-bound paclitaxel nanoparticles. Nano Lett 2023, 23, 939-947
31. Ting Wu, Tianqun Lang, Chao Zheng, Wenlu Yan, Yu Li, Runqi Zhu, Xin Huang, Huae Xu*, Yaping Li*, and Qi Yin*. Promote intratumoral drug release and penetration to counteract docetaxel-induced metastasis by photosensitizer-modified red blood Cell Membranes-coated nanoparticle. Adv Funct Mater 2023, 33, 2212109
32. Zitong Zhao, Jue Wang, Lei Fang, Xindi Qian, Ying Cai, Haiqiang Cao, Guanru Wang, Meilin He, Yanyan Jiang*, Dangge Wang*, Yaping Li*. Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer. Acta Pharmacol Sin 2023, 44, 244-254
33. Xiaochen Liu, Zitong Zhao, Xiangshi Sun, Jue Wang, Wenzhe Yi, Dangge Wang*, Yaping Li*. Blocking cholesterol metabolism with tumor-penetrable nanovesicles to improve photodynamic cancer immunotherapy. Small Methods 2023, 7, 2200898
34. Jie Li, Yao Wu, Jiaoying Wang, Xiaoxuan Xu, Ao Zhang*, Yaping Li*, Zhiwen Zhang*. Macrophage membrane-coated nano-gemcitabine promote lymphocytes infiltration and synergize antiPD-L1 to restore the tumoricidal function. ACS Nano 2023, 17, 322-336
35. Xindi Qian, Yuqi Wang, Honglei Xie, Chen Wang, Jie Li, Ying Lei, Huanzhen Liu, Yao Wu, Yaping Li*, Zhiwen Zhang*. Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy. J Control Release 2023, 353, 447-461
2022
36. Xiang Gong, Jie Li, Xiaoxuan Xu, Ying Lei, Huanzhen Liu, Xindi Qian, Yao Wu, Yaping Li, Zhiwen Zhang*. Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity. Biomaterials 2022,290,121855
37. Wenzhe Yi, Ping Xiao, Xiaochen Liu, Zitong Zhao, Xiangshi Sun, Jue Wang, Lei Zhou, Guanru Wang, Haiqiang Cao, Dangge Wang*, Yaping Li*. Designing active targeting and multi-functional drug delivery system via bioorthogonal chemistry. Sig Transduct Target Ther 2022,7,386
38. Jiaoying Wang; Jie Li; Yao Wu; Xiaoxuan Xu; Xindi Qian; Ying Lei; Huanzhen Liu; Zhiwen Zhang*; Yaping Li*. ROS-responsive nanocomplex of aPD-L1 and cabazitaxel improves intratumor delivery and potentiates radiation-mediated antitumor immunity. Nano Lett 2022,22,8312-8320
39. Wenlu Yan, Tianqun Lang, Wenhui Yuan, Qi Yin*, Yaping Li*. Nanosized drug delivery systems modulating immunosuppressive microenvironment for improving cancer immunotherapy. Acta Pharmacol Sin 2022,43,3045-3054
40. Zitong Zhao, Lei Fang, Ping Xiao, Xiangshi Sun, Lei Zhou, Xiaochen Liu, Jue Wang, Guanru Wang, Haiqiang Cao, Pengcheng Zhang, Yanyan Jiang,* Dangge Wang,* and Yaping Li*. Walking dead tumor cells for targeted drug delivery against lung metastasis of triple negative breast cancer. Adv Mater 2022,34, 2205462
41. Xindi Qian, Guanru Wang, Jie Li, Xinyue Zhang, Minghui Zhang, Qingmin Yang, Zhiwen Zhang*, Yaping Li*. Improving oral bioavailability of water-insoluble idebenone with bioadhesive liposomes. J Drug Deliv Sci Tec 2022, 75, 103640
42. Guanru Wang, Yaru Xie, Xindi Qian, Xinyue Zhang, Yanqiang Shan, Minghui Zhang, Jie Li, Zhiwen Zhang*, Yaping Li*. Poly (maleic anhydride-alt-1-octadecene)-based bioadhesive nanovehicles improve oral bioavailability of poor water-soluble gefitinib. Drug Dev Ind Pharm 2022,48,109-116
43. Xiaoting Shan, Xiang Gong, Jie Li, Jingyuan Wen, Yaping Li, Zhiwen Zhang*. Current approaches of nanomedicines in the market and various stage of clinical translation. Acta Pharm Sin B 2022, 12, 3028-3048
44. Chao Zheng, Wen Zhang, Yihui Zhai, Fengqin Xiong, Ying Cai, Xiang Gong, Binyu Zhu, Hao Wang*, Yaping Li*, Pengcheng Zhang*. Lenvatinib- and vadimezan-loaded synthetic high-density lipoprotein for combinational immunochemotherapy of metastatic triple-negative breast cancer. Acta Pharm Sin B 2022,12,3726-2728
45. Xindi Qian, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Jie Li, Shuo Chen, Jingyuan Wen, Yaping Li*, Zhiwen Zhang*. Strategies of engineering nanomedicines for tumor retention. J Control Release 2022,346,193-211
46. Yuqi Wang, Yao Wu, Honglei Xie, Shuzhou Xu, Yongping Li, Jie Li, Xiaoxuan Xu, Siling Wang*, Yaping Li*, Zhiwen Zhang*. Bioinspired lipoproteins of furoxans-oxaliplatin remodels physical barriers in tumor to potentiate T-cell infiltration. Adv Mater 2022,34,2110614
47. Lei Zhou, Bing Feng, Hao Wang*, Dangge Wang*, Yaping Li*. A bispecific nanomodulator to potentiate photothermal cancer immunotherapy. Nano Today 2022, 44,101466
48. Lei Fang, Zitong Zhao, Jue Wang, Ping Xiao, Xiangshi Sun, Yaping Ding, Pengcheng Zhang, Dangge Wang*, Yaping Li*. Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer. Acta Pharm Sin B 2022,12,353-363
49. Wenlu Yan, Tianqun Lang, Qi Yin*, Yaping Li*. Anti-hypoxia nanosized drug delivery systems improving cancer therapy. Nano Today 2022,42,101376
50. Xiaoxuan Xu, Yao Wu, Xindi Qian, Yuqi Wang, Jiaoying Wang, Jie Li, Yaping Li, Zhiwen Zhang*. Nanomedicine strategies to circumvent intratumor extracellular matrix barriers for cancer therapy. Adv Healthcare Mater 2022,11, 2101428
51. Ping Xiao, Yaping Li, Dangge Wang*. Amplifying antitumor T cell immunity with versatile drug delivery systems for personalized cancer immunotherapy. Med Drug Discov 2022,13,100116
2021
52. Yihui Zhai, JinmingWang,Tianqun Lang, Ying Kong, Rong Rong, Ying Cai,Wei Ran, Fengqin Xiong, Chao Zheng,Yanke Wang, Yang Yu, Helen H. Zhu, Pengcheng Zhang*, Yaping Li*. T lymphocyte membrane-decorated epigenetic nanoinducer of interferons for cancer immunotherapy. Nat Nanotechnol 2021,16,1271-1280
53. Runqi Zhu, Tianqun Lang, Qi Yin*, Yaping Li*. Nano drug delivery systems improve metastatic breast cancer therapy. Med Rev 2021,1,244-274
54. Yuqi Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Siling Wang*, Yaping Li*, Zhiwen Zhang*. M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors. J Nanobiotechnol 2021,19,397
55. Ping Xiao, Jue Wang, Lei Fang, Zitong Zhao, Xiangshi Sun, Xiaochen Liu, Haiqiang Cao, Pengcheng Zhang, Dangge Wang*, Yaping Li*. Nanovaccine-mediated cell selective delivery of neoantigens potentiating adoptive dendritic cell transfer for personalized immunization. Adv Funct Mater 2021, 31,2104068
56. Runqi Zhu, Tianqun Lang, Qi Yin*, Yaping Li*. Gut microbiota: influence on carcinogenesis and modulation strategies by drug delivery systems to improve cancer therapy. Adv Sci 2021,8,2003542
57. Pengcheng Zhang, Yaping Li*. Erythrocyte-mediated systemic immunotherapy. Nat Biomed Eng 2021,5,385-386
58. Zhiwan Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yaping Li, Xianyi Sha, Zhiwen Zhang*. Oxygen-delivering polyfluocarbon nanovehicles improve tumor oxygenation and potentiate photodynamic-mediated antitumor immunity. ACS Nano 2021,15,5405-5419
59. Ping Xiao, Jue Wang, Zitong Zhao, Xiaochen Liu, Xiangshi Sun, Dangge Wang*. Yaping Li*. Engineering nanoscale artificial antigen-Nowing cells by metabolic dendritic cell labeling to potentiate cancer immunotherapy. Nano Lett 2021,21,2094-2103
60. Junyang Wang, Chao Zheng Yihui Zhai, Ying Cai Robert J. Lee, Jianming Xing, Hao Wang, Helen. Zhu, Lesheng Teng,* Yaping Li,* Pengcheng Zhang,* High-density lipoprotein modulatestumor-associated macrophage for chemoimmunotherapy of hepatocellular carcinoma. Nano Today 2021,37,101064
61. Ying Cai, Chao Zheng, Fengqin Xiong, Wei Ran, Yihui Zhai, Helen H. Zhu, Hao Wang, Yaping Li*, Pengcheng Zhang*. Recent progress in the design and application of supramolecular peptide hydrogel in cancer therapy. Adv Healthcare Mater 2021,10,2001239
62. Tianqun Lang, Zhong Zheng, Xin Huang, Yiran Liu, Yihui Zhai, Pengcheng Zhang, Qi Yin* and Yaping Li*. Ternary regulation of tumour microenvironment by heparanase-sensitive micelle-loaded monocytes improves chemo-immunotherapy of metastatic breast cancer. Adv Funct Mater 2021,31,2007402
2020
63. Hong Wang Jie Li, Zhiwan Wang, Yuqi Wang, Xiaoxuan Xu, Xiang Gong, Jiaoying Wang, Zhiwen Zhang*, Yaping Li*. Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy. Biomaterials 2020,269,120609
64. Junjing Yin, Haiqiang Cao, Kaoxiang Sun*, Yaping Li*, Zhiwen Zhang*. Phospholipid membrane-coated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy. Acta Pharm Sin B 2020,10,2246-2257
65. Lei Fang, Zitong Zhao, Jue Wang, Pengcheng Zhang, Yaping Ding, Yanyan Jiang, Dangge Wang*, Yaping Li*. Engineering autologous tumour cell vaccine to locally mobilize antitumourimmunity in tumour surgical bed. Sci Adv 2020,6,eaba4024
66. Lei Zhou, Pengcheng Zhang, Hao Wang, Dangge Wang*, Yaping Li*. Smart nanosized drug delivery systems inducing immunogenic cell death for combination with cancer immunotherapy. Acc Chem Res 2020,53,1761-1772
67. Jie Li, Hong Wang, Yuqi Wang, Xiang Gong, Xiaoxuan Xu, Xianyi Sha, Ao Zhang*, Zhiwen Zhang*, Yaping Li*. Tumor-activated size-enlargeable bioinspired lipoproteins access cancer cells in tumor to elicit anti-tumor immune responses. Adv Mater 2020,32,2002380
68. Wenlu Yan, Tianqun Lang, Xianrong Qi, Yaping Li*. Engineering immunogenic cell death with nanosized drug delivery systems improving cancer immunotherapy. Curr Opin Biotech 2020, 66,36-43
69. Lei Zhou, Bo Hou, Dangge Wang, Fang Sun, Rundi Song, Qian Shao, Hao Wang, Haijun Yu*, Yaping Li*. Engineering polymeric prodrug nanoplatform for vaccination immunotherapy of cancer. Nano Lett 2020,20,4393-4402
70. Zhong Zheng, Tianqun Lang, Xin Huang, Guanru Wang, Robert J. Lee, Lesheng Teng*, Qi Yin* and Yaping Li*. Calcitriol-loaded dual-pH-sensitive micelle counteracts pro-metastasis effect of paclitaxel in triple-negative breast cancer therapy. Adv Healthcare Mater 2020, 9,2000392
71. Hao Su, Feihu Wang, Wei Ran, Weijie Zhang, Wenbing Dai, Han Wang, Caleb F Anderson, Zongyuan Wang, Chao Zheng, Pengcheng Zhang, Yaping Li, Honggang Cui*. The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers. Proc Natl Acad Sci USA 2020, 117,4518-4526
72. Jing Wang, Yuqi Wang, Haiqiang Cao, Hong Wang, Jie Li, Youxin Li, Yaping Li*, Zhiwen Zhang*. Orally delivered legumain-activated nanovehicles improve tumor accumulation and penetration for combinational photothermal-chemotherapy. J Control Release 2020, 323,59-70
73. Bo Hou, Lei Zhou, Hui Wang, Madiha Saeed, Dangge Wang, Zhiai Xu, Yaping Li, Haijun Yu*. Engineering stimuli-activatable boolean logic prodrug nanoparticles for combination cancer immunotherapy. Adv Mater 2020,32,1907210
74. Xiaoxuan Xu, Xiang Gong, Yuqi Wang, Jie Li, Hong Wang, Jiaoying Wang, Xianyi Sha, Yaping Li*, Zhiwen Zhang*. Reprogramming tumor associated macrophages towards M1 phenotypes with nanomedicine for anticancer immunotherapy. Adv Therapeutics 2020,3,1900181
75. Tao Tan, Yuqi Wang, Jing Wang, Zhiwan Wang, Hong Wang, Haiqiang Cao, Jie Li, Yaping Li*, Zhiwen Zhang*, Siling Wang*. Targeting peptide‒decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor. Acta Pharm Sin B 2020,10,529-545
76. Ying Cai, Wei Ran, Yihui Zhai, Junyang Wang, Chao Zheng, Yaping Li*, Pengcheng Zhang*. Recent progresses in supramolecular peptide assembly as virus mimicry for cancer immunotherapy. Biomater Sci 2020,8,1045-1057
77. Ang Gao, Binfan Chen, Jing Gao, Fengqi Zhou, Madiha Saeed, Bo Hou, Yaping Li*, Haijun Yu*. Sheddable prodrug vesicles combating adaptive immune resistance for improved photodynamic immunotherapy of cancer. Nano Lett 2020,20,353-362
78. Wei Ran, Xiaoyu Liu, Lu Chang, Ying Cai, Chao Zheng, Jia Liu, Yaping Li*, Pengcheng Zhang*. Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer. J Control Release 2020,318,234-245
79. Hong Wang, Jie Li, Yuqi Wang, Xiang Gong, Xiaoxuan Xu, Jiaoying Wang, Yaping Li*, Xianyi Sha, Zhiwen Zhang*. Nanoparticles-mediated reoxygenation strategy relieve tumor hypoxia for enhanced cancer therapy. J Control Release 2020,319,25-45
2019
80. Xiaochen Liu, Dangge Wang*, Pengcheng Zhang, Yaping Li*. Recent advances in nanosized drug delivery systems for overcoming the barriers to anti-PD immunotherapy of cancer. Nano Today 2019,29,100801
81. Bing Feng, Zifei Niu, Bo Hou, Lei Zhou, Yaping Li*, Haijun Yu*. Enhancing triple negative breast cancer immunotherapy by ICG-templated self-assembly of paclitaxel nanoparticles. Adv Funct Mater 2020,30,1906605
82. Dangge Wang, Tingting Wang, Haijun Yu,* Bing Feng, Lei Zhou, Fangyuan Zhou, Bo Hou, Hanwu Zhang, Min Luo, Yaping Li*. Engineering nanoparticles to locally activate T cells in the tumor microenvironment. Sci Immunol 2019, 4, eaau6584
83. Pengcheng Zhang, Yihui Zhai, Ying Cai, Yuliang Zhao*, Yaping Li*. Nanomedicine-based immunotherapy for the treatment of cancer metastasis. Adv Mater 2019,31,1904156
84. Yiran Liu, Tianqun Lang, Zhong Zheng, Hui Cheng, Xin Huang, Guanru Wang, Qi Yin*, and Yaping Li*. In vivo environment-adaptive nanocomplex with tumor cell-specific cytotoxicity enhances T cells infiltration and improves cancer therapy. Small 2019,15,1902822
85. Xiang Gong, Jie Li, Zhiwan Wang, Hong Wang, Yuqi Wang, Xiaoxuan Xu, Zhiwen Zhang*, Yaping Li*. Emerging approaches of cell-based nanosystems to target cancer metastasis. Adv Funct Mater 2019,29,1903441
86. Bing Feng, Bo Hou, Zhiai Xu, Madiha Saeed, HaijunYu*, Yaping Li*. Self-amplified drug delivery with light-inducible nanocargoes to enhance cancer immunotherapy. Adv Mater 2019,31,1902960
87. Junyang Wang, Jia Meng, Wei Ran, Robert J. Lee, Lesheng Teng*, Pengcheng Zhang*, Yaping Li*. Hepatocellular carcinoma growth retardation and PD-1 blockade therapy potentiation with synthetic high-density lipoprotein. Nano Lett 2019,19,5266-5276
88. Tao Tan, Haiyan Hu, Hong Wang, Jie Li, Zhiwan Wang, Jing Wang, Siling Wang, Zhiwen Zhang*, Yaping Li*. Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles. Nat Commun 2019,10,3322
89. Ang Gao, Xianli Hu, Madiha Saeed, Binfan Chen, Yaping Li*, Haijun Yu*. Overview and recent advances in liposomal nanoparticle-based cancer immunotherapy. Acta Pharmacol Sin 2019,40,1129-1137
90. Xiyue Zhao, Xiaoyu Liu, Pengcheng Zhang*, Yiran Liu, Wei Ran, Ying Cai, Junyang Wang, Yihui Zhai, Guanru Wang, Yaping Ding, Yaping Li*. Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma. Acta Pharm Sin B 2019,9,1050-1060
91. Fangyuan Zhou, Bing Feng, Haijun Yu*, Dangge Wang, Tingting Wang, Ang Gao, Siling Wang, Yuting Ma, Yaping Li*. Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade. Adv Mater 2019,31,1805888
92. Tianqun Lang, Xinyue Dong, Zhong Zheng, Yiran Liu, Guanru Wang, Qi Yin*, Yaping Li*. Tumor microenvironment-responsive docetaxel-loaded micelle combats metastatic breast cancer. Sci Bull 2019,64,91-100
93. Tianqun Lang, Yiran Liu, Zhong Zheng, Wei Ran, Yihui Zhai, Qi Yin*, Pengcheng Zhang, Yaping Li*. Cocktail strategy based on spatio-temporally controlled nano device improves therapy of breast cancer. Adv Mater 2019,31,1806202
2018
94. Junyu Cai, Hao Wang, Dangge Wang*, Yaping Li*. Improving cancer vaccine efficiency by nanomedicine. Adv Biosys 2018,3,e1800287
95. Tianqun Lang, Qi Yin*, Yaping Li*. Progress on cells-derived biomimetic drug delivery systems for cancer therapy. Adv Therapeutics 2018,1,1800053
96. Tao Tan, Yuqi Wang, Hong Wang, Haiqiang Cao, Zhiwan Wang, Jing Wang, Jie Li, Yaping Li, Zhiwen Zhang*, Siling Wang*. Apoferritin nanocages loading mertansine enable effective eradiation of cancer stem-like cells in vitro. Int J Pharm 2018,553,201-209
97. Tao Tan, Hong Wang, Haiqiang Cao, Lijuan Zeng, Yuqi Wang, Zhiwan Wang, Jing Wang, Jie Li, Siling Wang*, Zhiwen Zhang*, Yaping Li*. Deep tumor-penetrated nanocages improve accessibility to cancer stem cells for photothermal-chemotherapy of breast cancer metastasis. Adv Sci 2018,5,1801012
98. Zhiwen Zhang*, Hong Wang, Tao Tan, Jie Li, Zhiwan Wang, Yaping Li*. Rational design of nanoparticles with deep tumor penetration for effective treatment of tumor metastasis. Adv Funct Mater 2018,28,1801840
99. Haiqiang Cao, Hong Wang, Xinyu He, Tao Tan, Haiyan Hu, Zhiwan Wang, Jing Wang, Jie Li, Zhiwen Zhang*, Yaping Li*. Bioengineered macrophages can responsively transform into nanovesicles to target lung metastasis. Nano Lett 2018,18,4762-4770
100. Haiyan Hu, Jing Wang, Hong Wang, Tao Tan, Jie Li, Zhiwan Wang, Kaoxiang Sun*, Yaping Li*, Zhiwen Zhang*. Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy. Theranostics 2018,8,3597-3610
101. Bing Feng, Fangyuan Zhou, Bo Hou, Dangge Wang, Tingting Wang, Yuanlei Fu, Yuting Ma, Haijun Yu*, Yaping Li*. Binary cooperative prodrug nanoparticles improve immunotherapy by synergistically modulating immune tumor microenvironment. Adv Mater 2018,30,1803001
102. Yihui Zhai, Wei Ran, Jinghan Su, Tianqun Lang, Jia Meng, Guanru Wang, Pengcheng Zhang*, Yaping Li*. Traceable bioinspired nanoparticle for the treatment of metastatic breast cancer via NIR-trigged intracellular delivery of methylene blue and cisplatin. Adv Mater 2018,30,1802378
103. Tianqun Lang, Wei Ran, Xinyue Dong, Zhong Zheng, Yiran Liu, Qi Yin*, Yaping Li*. Tumor cells-selective bionic nanodevice exploiting heparanase combats metastatic breast cancer. Adv Funct Mater 2018,28,1707289
104. Pengcheng Zhang, Yonggang Cui, Caleb F. Anderson, Chunli Zhang, Yaping Li,* Rongfu Wang,* Honggang Cui*. Peptide-based nanoprobes for molecular imaging and disease diagnostics. Chem Soc Rev 2018,47,3490-3529
105. Tingting Wang, Dangge Wang, Haijun Yu,* Bing Feng, Fangyuan Zhou, Hanwu Zhang, Lei Zhou, Shi Jiao, Yaping Li*. A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors. Nat Commun 2018,9,1532
106. Qingshuo Meng, Jia Meng, Wei Ran, Junyang Wang, Yihui Zhai, Pengcheng Zhang*, Yaping Li*. Light-activated core-shell nanoparticles for spatiotemporally specific treatment of metastatic triple-negative breast cancer. ACS Nano 2018,12,2789-2802
107. Lei Zhou, Hao Wang, Yaping Li*. Stimuli-responsive nanomedicines for overcoming cancer multidrug resistance. Theranostics 2018,8,1059-1074
108. Bin He, Tao Tan, Hong Wang, Haiyan Hu, Zhiwan Wang, Jing Wang, Jie Li, Kaoxiang Sun, Zhiwen Zhang*, Yaping Li*. Rational design of tumor microenvironment-activated micelles for programmed targeting of breast cancer metastasis. Adv Funct Mater 2018,28,1705622
2017
109. Bin He, Haiyan Hu, Tao Tan, Hong Wang, Kaoxiang Sun*, Yaping Li, Zhiwen Zhang*. IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice. Acta Pharmacol Sin 2018,39,132-139
110. Tianqun Lang, Xinyue Dong, Yan Huang, Wei Ran, Qi Yin*, Pengcheng Zhang, Zhiwen Zhang, Haijun Yu, Yaping Li*. Ly6Chi monocytes delivering pH-sensitive micelle loading paclitaxel improve targeting therapy of metastatic breast cancer. Adv Funct Mater 2017,27,1701093
111. Fangyuan Zhou, Bing Feng, Tingting Wang, Dangge Wang, Zhirui Cui, Siling Wang*, Chunyong Ding, Zhiwen Zhang, Jian Liu, Haijun Yu*, Yaping Li*. Theranostic prodrug vesicles for reactive oxygen species-triggered ultrafast drug release and local regional therapy of metastatic triple negative breast cancer. Adv Funct Mater 2017,27,1703674
112. Fangyuan Zhou, Bing Feng, Tingting Wang, Dangge Wang, Qingshuo Meng, Jianfeng Zeng, Zhiwen Zhang, Siling Wang, Haijun Yu*, Yaping Li*. Programmed multiresponsive vesicles for enhanced tumor penetration and combination therapy of triple-negative breast cancer. Adv Funct Mater 2017,27,1606530
113. Haiqiang Cao, Lili Zou, Bin He, Lijuan Zeng, Yongzhuo Huang, Haijun Yu, Pengcheng Zhang, Qi Yin, Zhiwen Zhang*, Yaping Li*. Albumin biomimetic nanocorona improves tumor targeting and penetration for synergistic therapy of metastatic breast cancer. Adv Funct Mater 2017,27,1605679
114. Qiang Feng, Jianping Liu, Xuanyu Li, Qinghua Chen, Jiashu Sun*, Xinghua Shi, Baoquan Ding, Haijun Yu*, Yaping Li, Xingyu Jiang*. One-step microfluidic synthesis of nanocomplex with tunable rigidity and acid-switchable surface charge for overcoming drug resistance. Small 2017,13,1603109
115. Xinyue Dong, Tianqun Lang, Qin Yin*, Pengcheng Zhang, Yaping Li*. Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer. Acta Pharmacol Sin 2017,38,1655-1662
116. Qingshuo Meng, Jia Meng, Wei Ran, Jinghan Su, Yuguang Yang, Pengcheng Zhang*, Yaping Li*. Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance. Chem Comm 2017,53,12438-12441
117. Jianping Liu, Tingting Wang, Dangge Wang, Anjie Dong*, Yaping Li, Haijun Yu*. Smart nanoparticles improve therapy for drug resistant tumors by overcoming pathophysiological barriers. Acta Pharmacol Sin 2017,38,1-8
118. Yongzhuo Huang*, Yaping Li. Cancer nanobiotechnolgy. Acta Pharmacol Sin 2017,38,735-737
119. Tao Zhong, Bin He, Haiqiang Cao, Tao Tan, Haiyan Hu, Yaping Li, Zhiwen Zhang*, Treating breast cancer metastasis with cabazitaxel loaded polymeric micelles. Acta Pharmacol Sin 2017,38,924-930
120. Bing Feng, Fangyuan Zhou, Wenchao Lu, Dangge Wang, Tingting Wang, Cheng Luo, Hao Wang, Yaping Li, Haijun Yu*. Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer. Biomater Sci 2017,5,1522-1525
121. Xinyu He, Haiqiang Cao, Hong Wang, Tao Tan, Haijun Yu, Pengcheng Zhang, Qi Yin, Zhiwen Zhang*, Yaping Li*. Inflammatory monocytes loading protease-sensitive nanoparticles enable lung metastasis targeting and intelligent drug release for anti-metastasis therapy. Nano Lett 2017,17,5546-5554
122. Jieying Yin, Tianqun Lang, Dongmei Cun, Zhong Zheng, Yan Huang, Qi Yin*, Haijun Yu, Yaping Li*. pH-sensitive nano-complexes overcome drug resistance and inhibit metastasis of breast cancer by silencing Akt expression. Theranostics 2017,7,4204-4216
123. Tingting Wang, Dangge Wang, Jianping Liu, Bing Feng, Fangyuan Zhou, Hanwu Zhang, Lei Zhou, Qi Yin, Zhiwen Zhang, Zhonglian Cao, Haijun Yu*, Yaping Li*. Acidity-triggered ligand-presenting nanoparticles to overcome sequential drug delivery barriers to tumors. Nano Lett 2017,17,5429-5436
124. Chunhua Hu, Xiaoyu Liu, Wei Ran, Jia Meng, Yihui Zhai, Pengcheng Zhang *, Qi Yin, Haijun Yu, Zhiwen Zhang, Yaping Li*. Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer. Biomaterials 2017,144,60-72
125. Yihui Zhai, Jinghan Su, Wei Ran, Pengcheng Zhang*, Qi Yin, Zhiwen Zhang, Haijun Yu, Yaping Li*. Preparation and application of cell membrane-camouflaged nanoparticles for cancer therapy. Theranostics 2017,7,2575-2592
126. Lijun Sun, Dangge Wang, Yu Chen*, Liying Wang, Ping Huang, Yaping Li*, Ziwei Liu, Heliang Yao, Jianlin Shi*. Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer. Biomaterials 2017,133,219-228
127. Jinghan Su, Huiping Sun, Qingshuo Meng, Pengcheng Zhang, Qi Yin, Yaping Li*. Enhanced blood suspensibility and laser-activated tumor-specific drug release of theranostic mesoporous silica nanoparticles by functionalizing with erythrocyte membranes. Theranostics 2017,7,523-537
128. Huiping Sun, Jinghan Su, Qingshuo Meng, Qi Yin, Lingli Chen, Wangwen Gu, Zhiwen Zhang, Haijun Yu, Pengcheng Zhang, Siling Wang*, Yaping Li*. Cancer cell membrane-coated gold nanocages with hyperthermia-triggered drug release and homotypic target inhibit growth and metastasis of breast cancer. Adv Funct Mater 2017,27,1604300
129. Yingzhi Chen, Meng Zhang, Hongyue Jin, Yisi Tang, Huiyuan Wang, Qin Xu, Yaping Li, Feng Li, Yongzhuo Huang*. Intein-mediated site-specific synthesis of tumor-targeting protein delivery system: Turning PEG dilemma into prodrug-like feature. Biomaterials 2017,116,57-68
2016
130. Haijun Yu, Yaping Li*. pH and near-infrared light-responsive micelles with hyperthermia-triggered tumor penetration reverse multidrug resistance in breast cancer. Nanomed-Nanotechol 2016,12,461
131. Huiping Sun, Jinghan Su, Qingshuo Meng, Qi Yin, Zhiwen Zhang, Haijun Yu, Pengcheng Zhang, Siling Wang*, Yaping Li*. Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro. Acta Pharmacol Sin 2016,37,941-949
132. Shan Tang, Qingshuo Meng, Huiping Sun, Jinghan Su, Qi Yin*, Zhiwen Zhang, Haijun Yu, Lingli Chen, Wangwen Gu, Yaping Li*. Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer. Biomaterials 2016,114,44-53
133. Huiping Sun, Jinghan Su, Qingshuo Meng, Qi Yin, Lingli Chen, Wangwen Gu, Pengcheng Zhang, Zhiwen Zhang, Haijun Yu, Siling Wang*, Yaping Li*. Cancer-cell-biomimetic nanoparticles for targeted therapy of homotypic tumors. Adv Mater 2016,28,9581-9588
134. Bing Feng, Fangyuan Zhou, Zhiai Xu, Tingting Wang, Dangge Wang, Jianping Liu, Yuanlei Fu, Qi Yin, Zhiwen Zhang, Haijun Yu,* Yaping Li*. Versatile prodrug nanoparticles for acid-triggered precise imaging and organelle-specific combination cancer therapy. Adv Funct Mater 2016,26,7431-7442
135. Jinghan Su, Huiping Sun, Qingshuo Meng, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Haijun Yu, Yaping Li*. Bioinspired nanoparticles with NIR-controlled drug release for synergetic chemophotothermal therapy of metastatic breast cancer. Adv Funct Mater 2016,26,7495-7506
136. Fengyang Wang, Qianqian Sun, Bing Feng, Zhiai Xu*, Junying Zhang, Jie Xu, Linlin Lu,, Haijun Yu, Mingwei Wang, Yaping Li, Wen Zhang*. Polydopamine-functionalized graphene oxide loaded with gold nanostars and doxorubicin for combined photothermal and chemotherapy of metastatic breast cancer. Adv Healthcare Mater 2016,5,2227-2236
137. Shan Tang, Qingshuo Meng, Huiping Sun, Jinghan Su, Qi Yin*, Zhiwen Zhang, Haijun Yu, Lingli Chen, Yi Chen, Wangwen Gu, Yaping Li*. Tumor-microenvironment-adaptive nanoparticles codeliver paclitaxel and siRNA to inhibit growth and lung metastasis of breast cancer. Adv Funct Mater 2016,26,6033-6046
138. Dangge Wang, Tingting Wang, Jianping Liu, Haijun Yu*, Shi Jiao, Bing Feng, Fangyuan Zhou, Yuanlei Fu, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Zhaocai Zhou, Yaping Li*. Acid-activatable versatile micelleplexes for PD-L1 blockade-enhanced cancer photodynamic immunotherapy. Nano Lett 2016,16,5503-5513
139. Lijuan Zeng, Lili Zou, Haijun Yu, Xinyu He, Haiqiang Cao, Zhiwen Zhang*, Qi Yin, Pengcheng Zhang, Wangwen Gu, Lingli Chen, Yaping Li*. Treatment of malignant brain tumor by tumor-triggered programmed wormlike micelles with precise targeting and deep penetration. Adv Funct Mater 2016,23,4201-4012
140. Haiqiang Cao, Zhaoling Dan, Xinyu He, Zhiwen Zhang*, Haijun Yu, Qi Yin, Yaping Li*. Liposomes coated with isolated macrophage membrane can target lung metastasis of breast cancer. ACS Nano 2016,10,7738-7748
141. Lili Zou, Hong Wang, Bin He, Lijuan Zeng, Tao Tan, Haiqiang Cao, Xinyu He, Zhiwen Zhang*, Shenrong Guo, Yaping Li*. Current approaches of photothermaltherapy in treating cancer metastasis with nanotherapeutics. Theranostics 2016,6,762-772.
142. Jinghan Su, Huiping Sun, Qingshuo Meng, Qi Yin, Shan Tang, Yi Chen, Zhiwen Zhang, Haijun Yu, Yaping Li*. Long circulation red‐blood‐cell‐mimetic nanoparticles with peptide‐enhanced tumor penetration for simultaneously inhibiting growth and lung metastasis of breast cancer. Adv Funct Mater 2016,26,1243-1252
143. Pengcheng Zhang, Chunhua Hu, Wei Ran, Jia Meng, Qi Yin, Yaping Li*. Recent progress in light-triggered nanotheranostics for cancer treatment. Theranostics 2016,6,948-968
144. Tingting Wang, Dangge Wang, Haijun Yu*, Mingwei Wang, Jianping Liu, Bing Feng+ Fangyuan Zhou, Qi Yin, Zhiwen Zhang, Yongzhuo Huang, Yaping Li*. Intracellularly acid-switchable multifunctional micelles for combinational photo/chemotherapy of drug resistant tumor. ACS Nano 2016,10,3496-3508.
145. Fangyuan Zhou, Bing Feng, Haijun Yu*, Dangge Wang, Tingting Wang, Jianping Liu, Qingshuo Meng, Siling Wang*, Pengcheng Zhang, Zhiwen Zhang, Yaping Li*. Cisplatin prodrug-conjugated gold nanocluster for fluorescence imaging and targeted therapy of breast cancer. Theranostics 2016,6,679-687.
146. Meiying Wu, Qingshuo Meng, Yu Chen*, Lingxia Zhang, Mengli Li, Xiaojun Cai, Yaping Li*, Pengcheng Yu, Linlin Zhang and Jianlin Shi*. Large pore-sized hollow mesoporous organosilica for redox-responsive gene delivery and syergistic cancer chemotherapy. Adv Mater 2016,28,1963-1969
147. Xinyu He, Haijun Yu, Xiaoyue Bao, Haiqiang Cao, Qi Yin, Zhiwen Zhang*, Yaping Li*. pH-responsive wormlike micelles with sequential metastasis targeting inhibit lung metastasis of breast cancer. Adv Healthcare Mater 2016,5,439-448
148. Zhaoling Dan, Haiqiang Cao, Xinyu He, Zhiwen Zhang, Lili Zou, Lijuan Zeng, Yan Xu, Qi Yin, Minghua Xu, Dafang Zhong, Haijun Yu, Qi Shen, Pengcheng Zhang, Yaping Li*. A pH-responsive host-guest nanosystem loading succinobucol suppresses lung metastasis of breast cancer. Theranostics 2016,6,435-445
149. Dangge Wang, Tingting Wang, Zhiai Xu, Haijun Yu,* Bing Feng, Junying Zhang, Chengyue Guo, Qi Yin, Zhiwen Zhang, Yaping Li*. Cooperative treatment of metastatic breast cancer using host-guest nanoplatform co-loaded with docetaxel and siRNA. Small 2016,12,488-498
150. Haijun Yu, Chengyue Guo, Bing Feng, Jianping Liu, Xianzhi Chen, Dangge Wang, Lesheng Teng, Youxin Li, Qi Yin, Zhiwen Zhang, Yaping Li*. Triple-layered pH-responsive micelleplexes loaded with siRNA and cisplatin prodrug for NF-Kappa B targeted treatment of metastatic breast cancer. Theranostics 2016,6,14-27
151. Bing Feng, Fangyuan Zhou, Dangge Wang, Zhiai Xu, Haijun Yu*, Yaping Li, Gold nanomaterials for treatment of metastatic cancer. Sci China Chem 2016,59,984-990
2015
152. Huiping Sun, Qingshuo Meng, Shan Tang, Jinghan Su, Qi Yin, Lingli Chen, Wangwen Gu, Haijun Yu, Zhiwen Zhang, Siling Wang*, Yaping Li*. Inhibition of breast cancer metastasis by pluronic copolymers with moderate hydrophilic-lipophilic balance. Mol Pharmceut 2015,12,3323-3331
153. Bing Feng, Zhiai Xu, Fangyuan Zhou, Haijun Yu*, Qianqian Sun, Dangge Wang, Zhaohui Tang, Haiyang Yu, Qi Yin, Zhiwen Zhang, Yaping Li*. Near infrared light-actuated gold nanorods with cisplatin-polypeptide wrapping for targeted therapy of triple negative breast cancer. Nanoscale 2015,7,14854-14864
154. Pengfei Xu, Qingshuo Meng, Huiping Sun, Qi Yin*, Haijun Yu, Zhiwen Zhang, Mi Cao, Yingyi Zhang, Yaping Li*. Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer. Biomaterials 2015,64,10-20.
155. Xinyu He, Xiaoyue Bao, Haiqiang Cao, Zhiwen Zhang*, Qi Yin, Wangwen Gu, Lingli Chen, Haijun Yu, Yaping Li*. Tumor-penetrating nanotherapeutics loading a near-infrared probe inhibit growth and metastasis of breast cancer. Adv Funct Mater 2015,25,2831-2839
156. Haijun Yu*, Zhirui Cui, Pengcheng Yu, Chengyue Guo, Bing Feng, Tongying Jiang, Siling Wang, Qi Yin, Dafang Zhong, Xiangliang Yang, Zhiwen Zhang, Yaping Li*. pH- and NIR light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release reverse doxorubicin resistance in breast cancer. Adv Funct Mater 2015,25,2489-2500
157. Chongshen Guo#, Haijun Yu#,*, Bing Feng, Weidong Gao, Mei Yan, Zhiwen Zhang, Yaping Li*, Shaoqing Liu*. Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent. Biomaterials 2015,52,407-416.
158. Jing Wang,Yadian Xie,Liming Wang,Jinglong Tang, Jiayang Li*, Duygu Kocaefe,Yasar Kocaefe,Zhiwen Zhang, Yaping Li, Chunying Chen*. In vivo pharmacokinetic features and biodistribution of star and rod shaped gold nanoparticles by multispectral optoacoustic tomography. RSC Adv 2015,5,7529-7538
159. Haiqiang Cao, Zhiwen Zhang*, Shuang Zhao, Xinyu He, Haijun Yu, Qi Yin , Zhiping Zhang, Wangwen Gu, Lingli Chen, Yaping Li*. Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression. J Control Release 2015,205,162-171
160. Haiqiang Cao, Yixin Wang, Xinyu He, Zhiwen Zhang*, Qi Yin Yi Chen, Haijun Yu, Yongzhuo Huang, Lingli Chen, Minghua Xu, Wangwen Gu, Yaping Li*. Codelivery of sorafenib and curcumin by directed self-assembled nanoparticles enhances therapeutic effect on hepatocellular carcinoma. Mol Pharmaceut 2015,12,922-931
161. Pengcheng Zhang, Andrew G. Cheetham, Yaping Li, Honggang Cui*. Activatable Nanoprobes for biomolecular detection. Curr Opin Biotech 2015,34,171-179
162. Shan Tang, Qi Yin*, Jinghan Su, Huiping Sun, Qingshuo Meng, Yi Chen, Lingli Chen, Yongzhuo Huang, Wangwen Gu, Minghua Xu, Haijun Yu, Zhiwen Zhang, Yaping Li*. Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel. Biomaterials 2015,48,1-15
163. Pengcheng Yu, Haijun Yu*, Chengyue Guo, Zhirui Cui, Xianzhi Chen, Qi Yin, Pengcheng Zhang, Xiangliang Yang*, Honggang Cui, Yaping Li*. Reversal of doxorubicin resistance in breast cancer by mitochondria-targeted pH-responsive micelles. Acta Biomater 2015,14,115-124
164. Rong Sun, Yang Liu, Shiyong Li, Song Shen, Xiaojiao Du, Congfei Xu, Zhiting Cao, Yan Bao, Yanhua Zhu, Yaping Li, Xianzhu Yang, Jun Wang*. Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells. Biomaterials 2015, 37,405-414
165. Meiying Wu, Qingshuo Meng, Yu Chen*, Yanyan Du, Lingxia Zhang, Yaping Li*, Linlin Zhang, Jianlin Shi*. Large pore-sized ultrasmall mesoporous organosilica nanoparticles: micelle/precursor co-templating assembly and nuclear-targeted gene delivery. Adv Mater 2015,27,215-222.
166. Qi Yin, Jianan Shen, Haijun Yu, Yongzhuo Huang*, Zhiwen Zhang and Yaping Li*. Bioreducible micelles with endosomal buffering and multidrug resistance-reversing function enhance anti-tumor efficacy of doxorubicin. J Biomed Nanotechnol 2015,11,1764-1775
2014
167. Zhiwen Zhang, Haiqiang Cao, Shijun Jiang, Zeying Liu, Xinyu He, Haijun Yu, Yaping Li*. Nanoassembly of probucol enables novel therapeutic efficacy in the suppression of lung metastasis of breast cancer. Small 2014,10,4735-4745.
168. Haijun Yu, Zhiai Xu, Xianzhi Chen, L Xu, Qi Yin, Zhiwen Zhang, Yaping Li*. Reversal of lung cancer multidrug resistance by pH-responsive micelleplexes mediating co-delivery of siRNA and paclitaxel. Macromol Biosci 2014,14,100-109
169. Yaping Wang, Yifan Jiang, Meng Zhang, Jiao Tan, Jianming Liang, Huixin Wang, Yaping Li, Huining He, Victor C. Yang*, Yongzhuo Huang*. Protease-activatable hybrid nanoprobe for tumor imaging. Adv Funct Mater 2014,24,5443-5453
170. Yu Chen, Qingshuo Meng, Meiying Wu, Shige Wang, Pengfei Xu, Hangrong Chen, Yaping Li.* Lingxia Zhang, Lianzhou Wang,* Jianlin Shi*. Hollow mesoporous organosilica nanoparticles: a generic intelligent framework-hybridization approach for biomedicine. J Am Chem Soc 2014,136,16326-16334.
171. Qing Yuan, Wenshu Cong, Ying Ge, Dandan Ma, Jing Han, Zhaoxia Dai, Yaping Li*, Xiaolin Bi*. Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. Int J Nanomed 2014,9,4829-4846
172. Jianan Shen, Huiping Sun, Qingshuo Meng, Qi Yin, Zhiwen Zhang, Haijun Yu, Yaping Li*. Simultaneous inhibition of tumor growth and angiogenesis for resistant hepatocellular carcinoma by co-delivery of sorafenib and survivin small hairpin RNA. Mol Pharmaceut 2014,11,3342-3351
173. Jianan Shen, Qingshuo Meng, Huiping Sui, Qi Yin, Zhiwen Zhang, Haijun Yu, Yaping Li*. iRGD conjugated TPGS mediates co-delivery of paclitaxel and survivin shRNA for reversal of lung cancer resistance. Mol Pharmaceut 2014,11,2579-2591
174. Zhiwen Zhang*, Shijun Jiang, Zeying Liu, Baohua Niu, Wangwen Gu, Yaping Li*, Jingbin Cui. Directed self-assembled nanoparticles of probucol improve oral delivery: fabrication, performance and correlation. Pharm Res 2014,31,2266-2275
175. Linlin Wang, Yujiao Sun, Shi C, Liang Li, Jian Guan, Xin Zhang, Rui Ni, Xiaopin Duan, Yaping Li, Shirui Mao*.Uptake, transport and peroral absorption of fatty glyceride grafted chitosan copolymer-enoxaparin nanocomplexes: Influence of glyceride chain length. Acta Biomater 2014,10,3675-3685
176. Jisheng Xiao, Xiaopin Duan, Qingshuo Meng, Qi Yin, Zhiwen Zhang, Haijun Yu, Lingli Chen, Wangwen Gu, Yaping Li*. Effective delivery of p65 shRNA by optimized Tween 85-polyethyleneimine conjugate for inhibition of tumor growth and lymphatic metastasis. Acta Biomater 2014,10,2674-2683
177. Yu Chen, Pengfei Xu, Zhu Shu, Meiying Wu, Lianzhou Wang, Shengjian Zhang, Yuanyi Zheng, Hangrong Chen,* Jin Wang, Yaping Li*, Jianlin Shi*. Multifunctional graphene oxide-based triple stimuli-responsive nanotheranostics. Adv Funct Mater 2014,24,4386-4396
178. Meiying Wu, Qingshuo Meng, Yu Chen, Pengfei Xu, Shengjian Zhang, Yaping Li*, Lingxia Zhang, Min Wang, Heliang Yao and Jianlin Shi*. Ultrasmall confined iron oxide nanoparticle MSNs as a pH-responsive theranostic platform. Adv Funct Mater 2014,24,4273-4283
179. Yongzhuo Huang*, Yaping Li*. Drug delivery and reversal of MDR. Mol Pharmaceut 2014,11,2493-2494
180. Wenquan Zhu, Qinfu Zhao, Changshan Sun, Zhiwen Zhang, Tongying Jiang, Jin Sun, Yaping Li, Siling Wang*. Mesoporous carbon with spherical pores as a carrier for celecoxib with needle-like crystallinity: Improve dissolution rate and bioavailability. Mater Sci Eng C 2014,39,13-20
181. Pengfei Xu, Haijun Yu, Zhiwen Zhang, Qingshuo Meng, Huiping Sun, Xianzhi Chen, Qi Yin, Yaping Li*. Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis. Biomaterials 2014,35,7574-7587
182. Dangge Wang, Zhiai Xu, Haijun Yu*, Xianzhi Chen, Bing Feng, Zhirui Cui, Bin Lin, Qi Yin, Zhiwen Zhang, Chunying Chen, Jun Wang, Wen Zhang, Yaping Li*. Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods. Biomaterials 2014,35,8374-8384.
183. Yu Chen, Pengfei Xu, Meiying Wu, Qingshuo Meng, Hangrong Chen,* Zhu Shu, Jin Wang, Lingxia Zhang, Yaping Li* and Jianlin Shi*. Colloidal RBCs-shaped, hydrophilic and hollow mesoporous carbon nanocapsules for highly efficient biomedical engineering. Adv Mater 2014,26,4294-4301
184. Linlin Wang, Liang Li, Yujiao Sun, Jiaojiao Ding, Jinfeng Li, Xiaopin Duan, Yaping Li, Varaporn B. Junyaprasert, Shirui Mao*. In vitro and in vivo evaluation of chitosan graft glyceryl monooleate as peroral delivery carrier of enoxaparin. Int J Pharm 2014,471,391-399
185. Shan Tang, Qi Yin, Zhiwen Zhang, Wangwen Gu, Lingli Chen, Haijun Yu, Yongzhuo Huang, Xianzhi Chen, Minghua Xu, Yaping Li*. Co-delivery of doxorubicin and RNA using pH-sensitive poly (β-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer. Biomaterials 2014,35,6047-6059
186. Huihui Bu, Xinyu He, Zhiwen Zhang*, Qi Yin, Haijun Yu, Yaping Li*. A TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer. Int J Pharm 2014,471,206-213
187. Xin Nie, Jiakun Zhang, Qing Xu, Xiaoguang Liu, Yaping Li, Yan Wu, Chunying Chen*. Targeting peptide iRGD-conjugated amphiphilic chitosan-co-PLA/DPPE drug delivery system for enhanced tumor therapy. J Mater Chem B 2014,2,3232-3242
188. Zhiwen Zhang, Baohua Niu, Jian Chen, Xinyu He, Xiaoyue Bao, Jianhua Zhu, Haijun Yu, Yaping Li*. The use of lipid-coated nanodiamond to improve bioavailability and efficacy of sorafenib in resisting metastasis of gastric cancer. Biomaterials 2014,35,4565-4572
189. Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li*. Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram. Nanotechnology 2014,25,125102
190. Xianzhu Yang, Xiaojiao Du, Yang Liu, Yanhua Zhu, Yangzhong Liu, Yaping Li, Jun Wang*. Rational design of polyion complex nanoparticlesto overcome cisplatin resistance in cancer therapy. Adv Mater 2014,26,931-936
191. Chunyang Sun, Shuang Dou, Jinzhi Du, Xianzhu Yang, Yaping Li, Jun Wang*. Doxorubicin conjugate of poly(ethylene glycol)-block-polyphosphoester for cancer therapy. Adv Healthc Mater 2014,3,261-272
2013
192. Yu Chen, Pengfei Xu, Hangrong Chen, Yongsheng Li, Wenbo Bu, Zhu Shu, Yaping Li*, Jiamin Zhang, Lingxia Zhang, Limin Pan, Xiangzhi Cui, Zile Hua, Jin Wang, Linlin Zhang and Jianlin Shi*. Colloidal HPMO nanoparticles:silica-etching chemistry tailoring, topological transformation and nano-biomedical applications. Adv Mater 2013, 25,3100-3105
193. Lei Xu, Jianming Feng, Jiaxin Li, Jinmei Zhu, Shanshan Song, Linjiang Tong, Yi Chen, Xinying Yang, Yanyan Shen, Fulin Lian, Yapin Li*, Donghai Lin, Jian Ding, Zehong Miao*. Tanshinone-1 induces tumor cell killing, enhanced by inhibition of secondary activation of signaling networks. Cell Death Dis 2013,4,e905
194. Haijun Yu, Xuetao Shi, Pengcheng Yu, Jianhua Zhou, Zhiwen Zhang, Hongkai Wu, Yaping Li*. pH-Responsive wormlike micelles for intracellular delivery of hydrophobic drugs. J Control Release 2013,172,e33-4
195. Zhiwen Zhang, Huihui Bu, Zeying Liu, Yixin Wang, Baohua Niu, Yaping Li*. Paclitaxel loaded self-assembled nanocarrier reduces multidrug resistance in lung cancer. J Control Release 2013,172,e96
196. Qi Yin, Jianan Shen, Zhiwen Zhang, Haijun Yu, Yaping Li*. Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor Adv Drug Deliv Rev 2013,65,1699-1715
197. Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li*. Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram. ACS Nano 2013,7,5858-5869
198. Huiyuan Wang, Qianqian Guo, Yifan Jiang, Ergang Liu, Yongxing Zhao, Huixin Wang, Yaping Li*, Yongzhuo Huang*. Co-delivery of cell-permeable chimeric apoptosis AVPIR8 peptide/p53 DNA for cocktail therapy. Adv Funct Mater 2013,23,6068-6075
199. Xiaopin Duan, Yaping Li*. Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization and trafficking. Small 2013,9,1521-1532
200. Zhiwen Zhang, Li Ma, Shijun Jiang, Zeying Liu, Jian Huang, Lingli Chen, Yaping Li*. A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor. J Control Release 2013,166,30-37
201. Jisheng Xiao, Xiaopin Duan, Qi Yin, Zhiwen Zhang, Haijun Yu, Yaping Li*. Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer. Biomaterials 2013,34,9648-9656
202. Jisheng Xiao, Xiaopin Duan, Qi Yin, Zehong Miao*, Haijun Yu, Chunying Chen, Zhiwen Zhang*, Jun Wang, Yaping Li*. The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles. Biomaterials 2013,34,5381-5390
203. Haijun Yu, Yonglong Zou, Lei Jiang, Qi Yin, Xinyu He, Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping Li*. Induction of apoptosis in non-small cell lung cancer by downregulation of MDM2 using pH-responsive PMPC-b-PDPA/siRNA complex nanoparticles. Biomaterials 2013,34,2738-2747
204. Jianan Shen, Huiping Sun, Pengfei Xu, Qi Yin, Zhiwen Zhang, Siling Wang, Haijun Yu, Yaping Li*. Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles. Biomaterials 2013,34,1581-1590
205. Chongshen Guo, Shu Yin*, Haijun Yu*, Shaoqin Liu, Qiang Dong, Takehiro Goto, Zhiwen Zhang, Yaping Li*, Tsugio Sato. Photothermal ablation cancer therapy using homogeneous CsxWO3 nanorods with broad near-infrared absorption. Nanoscale 2013,5,6469-6478
206. Qi Yin, Jianan Shen, Zhiwen Zhang, Haijun Yu, Lingli Chen, Wangwen Gu, Yaping Li*. Multifunctional nanoparticles improve therapeutic effect for breast cancer by simultaneously antagonizing multiple mechanisms of multidrug resistance. Biomacromolecules 2013,14,2242-2252
207. Haijun Yu, Zhiai Xu, Dangge Wang, Xianzhi Chen, Zhiwen Zhang, Qi Yin, Yaping Li*. Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery. Polym Chem 2013,4,5052-5055
208. Zhiwen Zhang , Zeying Liu, Li Ma, Shijun Jiang, Yixin Wang, Haijun Yu, Qi Yin, Jingbin Cui, Yaping Li*. Reversal of multidrug resistance by mitochondrial targeted self-assembled nanocarrier based on stearylamine. Mol Pharmaceut 2013,10,2426-34
209. Pengfei Xu, Qi Yin, Jianan Shen, Lingli Chen, Haijun Yu, Zhiwen Zhang, Yaping Li*. Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS. Int J Pharm 2013,454,21-30
210. Zhiwen Zhang, Fang Gao, Shijun Jiang, Lingli Chen, Zeying Liu, Haijun Yu, Yaping Li*. Bile salts enhance the intestinal absorption of lipophilic drug loaded lipid nanocarriers: mechanism and effect in rats. Int J Pharm 2013,452,374-381
211. Zhiwen Zhang, Jian Huang, Shijun Jiang, Zeying Liu, Wangwen Gu, Yaping Li*. Porous starch based self-assembled nano-delivery system improves the oral absorption of lipophilic drug. Int J Pharm 2013,444,162-168
212. Zhiwen Zhang, Jian Huang, Shijun Jiang, Zeying Liu, Wangwen Gu, Yaping Li*. A high drug loading self-assembled nanoemulsion enhances the oral absorption of probucol in rats. J Pharm Sci 2013,102,1301-1306
213. Qingshuo Meng, Qi Yin, Yaping Li*. Nanocarriers for siRNA delivery to overcome cancer multidrug resistance. Chinese Sci Bull 2013,58,4021-4030
2012
214. Ge Zhang, Baosheng Guo, Heng Wu, Tao Tang, Bao-Ting Zhang, Lizhen Zheng, Yixin He, Zhijun Yang, Xiaohua Pan, Heelum Chow, Kinwah To, Yaping Li, Dahu Li, Xinluan Wang, Yixiang Wang, Kwongman Lee, Zhibo Hou, Nan Dong, Gang Li, Kwoksui Leung, Leungkim Hung, Fuchu He, Lingqiang Zhang & Ling Qin. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nat Medicine 2012,18,307-314
215. Yu Chen, Yu Gao, Hangrong Chen, Deping Zeng, Yaping Li*, Yuanyi Zheng, Faqi Li, Xiufeng Ji, Xia Wang, Feng Chen, Qianjun He, Linlin Zhang, Jianlin Shi*. Engineering inorganic nanoemulsions/nanoliposomes by fluoride-Silica chemistry for efficient delivery/co-delivery of hydrophobic agents. Adv Funct Mater 2012,8,1586-1597
216. Pengcheng Zhang, Luojuan Hu, Qi Yin, Linyin Feng, Yaping Li*. Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: synthesis, preparation and in vivo evaluation. J Control Release 2012,159,429-434
217. Jianan Shen, Qi Yin, Lingli Chen, Zhiwen Zhang, Yaping Li*. Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer. Biomaterials 2012,33,8613-8624
218. Yu Chen, Qi Yin, Xiufeng Ji, Shengjian Zhang, Hangrong Chen, Yuanyi Zheng, Yang Sun, Haiyun Qu, Zheng Wang, Yaping Li*, Xia Wang, Kun Zhang, Linlin Zhang, Jianlin Shi*. Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells. Biomaterials 2012,33,7126-7137
219. Qi Yin, Jianan Shen, Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping Li*. Overcoming multidrug resistance by co-delivery of Mdr-1 and survivin-targeting RNA with reduction-responsible cationic poly(β-amino esters). Biomaterials 2012,33,6495-6506
220. Zhiwen Zhang, Fang Gao, Huihui Bu, Jisheng Xiao, Yaping Li*. Solid lipid nanoparticles loading candesartan cilexetil enhance oral bioavailability: in vitro characteristics and absorption mechanism in rats. Nanomedicine NBM 2012,8,740-747
221. Dechao Niu, Zhiwen Zhang, Shijun Jiang, Zhi Ma, Xiaohang Liu, Yongsheng Li, Liangping Zhou, Changsheng Liu*, Yaping Li* and Jianlin Shi*. Controlled synthesis of shell cross-linked magnetic micelles for efficient liver MR imaging. J Mater Chem 2012,22,24936-24944
222. Jisheng Xiao, Xiaopin Duan, Qi Yin, Lingli Chen, Zhiwen Zhang, Yaping Li*. Low molecular weight polyethylenimine-graft-Tween 85 for effective gene delivery: synthesis and in vitro characteristics. Bioconjugate Chem 2012,23,222-231
223. Pengcheng Zhang, Luojuan Hu, Qi Yin, Linyin Feng, Yaping Li*. Transferrin-modified c[RGDfK]-paclitaxel loaded hybrid micelle for sequential blood-brain barrier penetration and glioma targeting therapy. Mol Pharmaceut 2012,9,1590-1598
224. Zhiwen Zhang, Fang Gao, Shijun Jiang, Li Ma, Yaping Li*. Nano-based drug delivery system enhances the oral absorption of lipophilic drugs with extensive presystemic metabolism. Curr Drug Metab 2012,13,1110-1118
225. Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Shirui Mao, Yaping Li*. Amphiphilic graft copolymer based on poly(styrene-co-maleic anhydride) with low molecular weight polyethylenimine for efficient gene delivery. Int J Nanomed 2012,7,4961-4972
2011
226. Yu Gao, Yu Chen, Xiufeng Ji, Xinyu He, Qi Yin, Zhiwen Zhang, Jianlin Shi and Yaping Li*. Controlled intracellular release of doxorubicin in multidrug resistant cancer cells by tuning the shell-pore sizes of mesoporous silica nanoparticles. ACS Nano 2011,5,9788-9798
227. Yu Gao, Rongfu Yang, Zhiwen Zhang, Lingli Chen, Zuyue Sun, Yaping Li*. Solid lipid nanoparticles reduce systemic toxicity of docetaxel: performance and mechanism in animal. Nanotoxicology 2011,5,636-649
228. Qianjun He, Zhiwen Zhang, Fang Gao, Yaping Li*, Jianlin Shi*. In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: effects of particle size and PEGylation. Small 2011,7,271-280
229. Fang Gao, Zhiwen Zhang, Huihui Bu,Yan Huang, Zhiwei Gao, Jianan Shen, Chunjie Zhao, Yaping Li*. Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: performance and mechanism. J Control Release 2011,149,168-74
230. Qi Yin, Yu Gao, Zhiwen Zhang, Pengcheng Zhang, Yaping Li*. Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery. J Control Release 2011,151,35-44
231. Yu Gao, Lingli Chen, Zhiwen Zhang, Yi Chen, Yaping Li*. Reversal of multidrug resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA complex nanoparticles. Biomaterials 2011,32,1738-1747
232. Qianjun He, Yu Gao, Lingxia Zhang, Zhiwen Zhang, Fang Gao, Xiufeng Ji, Yaping Li*, Jianlin Shi*. A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance. Biomaterials 2011,32,7711-7720
233. Zhiwen Zhang, Yan Huang, Fang Gao, Huihui Bu, Wangwen Gu, Yaping Li*. Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats. Nanoscale 2011,3,1780-1787
234. Jianan Shen, Qianjun He, Yu Gao, Jianlin Shi* and Yaping Li*. Mesoporous silica nanoparticles loading doxorubicin reverse multidrug resistance: performance and mechanism. Nanoscale 2011,3,4314-4322
235. Qianjun He, Yu Gao, Lingxia Zhang, Wenbo Bu, Hangrong Chen, Yaping Li* and Jianlin Shi. One-pot self-assembly of mesoporous silica nanoparticle-based pH-responsive anti-cancer nano drug delivery system. J Mater Chem 2011,21,15190-15192
236. Zhiwen Zhang, Yan Huang, Fang Gao, Zhiwei Gao, Huihui Bu, Wangwen Gu, Yaping Li*. A self-assembled nano-delivery system enhancing the oral bioavailability of daidzein: in vitro characteristics and in vivo performance. Nanomedicine UK 2011,6,1365-379
237. Yu Gao, Qi Yin, Lingli Chen, Zhiwen Zhang, Yaping Li*. The linear cationic click polymers/DNA nanoparticles: in vitro structure-activity relationship and in vivo evaluation for gene delivery. Bioconjugate Chem 2011,22,1153-1161
238. Yongxin Yang, Yu Gao, Lingli Chen, Yongzhuo Huang*, Yaping Li*. Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles. Int J Pharm 2011,405,188-195
239. Xiufeng Ji, Yu Gao, Lingli Chen, Zhiwen Zhang, Yihui Deng, Yaping Li*. Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance. Int J Pharm 2011,422,390-397
2010
240. Zhenghong Xu, Zhiwen Zhang, Yi Chen, Lingli Chen, Yaping Li*. The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model. Biomaterials 2010,31,916-922
241. Yongxin Yang, Zhiwen Zhang, Lingli Chen, Wangwen Gu, Yaping Li*. Galactosylated poly(2-(2-aminoethyoxy)ethoxy)phosphazene/DNA complex nanoparticles: in vitro and in vivo evaluation for gene delivery. Biomacromolecules 2010,11,927-933
242. Yu Gao, Lingli Chen, Zhiwen Zhang,Wangwen Gu, Yaping Li*. Linear cationic click polymer for gene delivery: synthesis, biocompatibility and in vitro transfection. Biomacromolecules 2010,11,3102-3111.
243. Yongxin Yang, Lingli Chen, Wangwen Gu, Zhiwen Zhang, Yaping Li*. Urocanic acid improves transfection efficiency of polyphosphazene with primary amino groups for gene delivery. Bioconjugate Chem 2010, 21,419-426
244. Pengcheng Zhang, Luojuan Hu, Yucai Wang, Jun Wang, Linyin Feng, Yaping Li*. Poly(ε-caprolactone)-block-poly(ethyl ethylene phosphate) micelles for brain targeting drug delivery: in vitro and in vivo valuation. Pharm Res 2010,27,2657-2669.
245. Zhenghong Xu, Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping Li*. "Intelligent" nanoassembly for gene delivery: In vitro transfection and the possible mechanism. Int J Pharm 2010,383,271-276
246. Yu Gao, Pengfei Xu, Lingli Chen, Yaping Li*. Prostaglandin E1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect. Int J Pharm 2010,387,263-271
247. Yongxin Yang, Zhiwen Zhang, Lingli Chen, Yaping Li*. Effect of multifold charge groups and imidazole-4-carboxaldehyde on physicochemical characteristics and transfection of cationic polyphosphazenes/DNA complexes. Int J Pharm 2010,390,191-197
248. Pengcheng Zhang, Zhiwen Zhang, Yongxin Yang, Yaping Li*. Folate-PEG modified poly(2-(2-aminoethoxy)ethoxy)phosphazene /DNA nanoparticles for gene delivery: synthesis, preparation and in vitro transfection efficiency. Int J Pharm 2010,392,241-248
249. Zhiwen Zhang, Huihui Bu, Zhiwei Gao, Yan Huang, Fang Gao, Yaping Li*. The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats. Int J Pharm 2010,394,147-153
250. Huihui Bu, Yu Gao, Yaping Li*. Overcoming multidrug resistance (MDR) in cancer by nanotechnology. Sci China Chem 2010,11,1-7
251. Pengcheng Zhang, Lingli Chen, Zhiwen Zhang, Liping Lin and Yaping Li*. Pharmacokinetics in rats and efficacy in murine ovarian cancer model for solid lipid nanoparticles loading docetaxel. J Nanosci Nanotech 2010,10,7541-7544
252. Kongrong Duan, Xiaolan Zhang, Xiaoxing Tang, Jiahui Yu, Shiyuan Liu, Daxin Wang, Yaping Li, Jin Huang*. Fabrication of cationic nanomicelle from chitosan-graft-polycaprolactone as the carrier of 7-ethyl-10-hydroxy- camptothecin. Colloid Surfac B 2010,76,475-482
253. Kongrong Duan, Honglin Chen, Jin Huang, Jiahui Yu*, Shiyuan Liu, Daxin Wang, Yaping Li. One-step synthesis of amino-reserved chitosan-graft- polycaprolactone as a promising substance of biomaterial. Carbohydr Polym 2010,80,499-504
254. Naiqian Fan, Kongrong Duan, Chengyun Wang, Shunying Liu, Shufang Luo, Jiahui Yu, Jin Huang, Yaping Li, Daxin Wang. Fabrication of nanomicelle with enhanced solubility and stability of camptothecin based on ,-poly[(N-carboxybutyl)-L-aspartamide] -camptothecin conjugate. Colloid Surfac B 2010,75,543-549
255. Weilu Zhang, Jin Huang, Naiqian Fan, Jiahui Yu, Yongbiao Liu, Shiyuan Liu*, Daxin Wang, Yaping Li, Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated α,β-poly (l-aspartic acid)-camptothecin conjugate. Colloid Surfac B 2010,81,297-303
256. Honglei Fan, Jin Huang*, Yaping Li, Jiahui Yu*, Jinghua Chen. Fabrication of reduction-degradable micelle based on disulfide-linked graft copolymer-camptothecin conjugate for enhancing solubility and stability of camptothecin. Polymer 2010,51,5107-5114
257. Jin Huang, Feng Gao, Xiaoxin Tang, Jiahui Yu*, Daxin Wang, Shiyuan Liu*, Yaping Li. Liver-targeting doxorubicin-conjugated polymeric prodrug with pH‐triggered drug release profile. Polym Int. 2010,59,1390-1396
2009
258. Qianjun He Zhiwen Zhang, Yu Gao, Jianlin Shi* and Yaping Li*. Intracellular localization and cytotoxicity of spherical mesoporous silica nano- and microparticles. Small 2009,5,2722-2729
259. Zhenghong Xu, Lingli Chen, Wangwen Gu, Yu Gao, Liping Lin, Zhiwen Zhang, Yong Xi, Yaping Li*. The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma. Biomaterials 2009,30,226-232.
260. Yu Gao, Zhiwen Zhang, Lingli Chen, Wangwen Gu, and Yaping Li*. Synthesis of 6-N,N,N-Trimethyltriazole chitosan via “click chemistry” and evaluation for gene delivery. Biomacromolecules 2009,10,2175-2182
261. Yu Gao, Zhiwen Zhang, Lingli Chen, Wangwen Gu, Yaping Li*. Chitosan N-betainates/DNA self-assembly nanoparticles for gene delivery: in vitro uptake and transfection efficiency. Int J Pharm 2009,371,156-162
2008
262. Yu Gao, Lingli Chen, Wangwen Gu, Yong Xi, Liping Lin, Yaping Li*. Targeted nanoassembly loaded with docetaxel improves intracellular drug delivery and efficacy in murine breast cancer model. Mol Pharmceut 2008,5,1044-1054
263. Yu Gao, Wangwen Gu, Lingli Chen, Zhenghong Xu, Yaping Li*. The role of daidzein-loaded sterically stabilized solid lipid nanoparticles in therapy for cardio-cerebrovascular diseases. Biomaterials 2008,29,4129-4136
264. Yongxin Yang, Zhenghong Xu, Jingui Jiang, Yu Gao, Wangwen Gu, Yaping Li*. Poly(imidazole/DMAEA)phosphazene/DNA self-assembled nanoparticles for gene delivery: synthesis and in vitro transfection. J Control Release 2008,127,273-279.
265. Zhenghong Xu, Wangwen Gu, Lingli Chen, Yu Gao, Zhiwen Zhang, Yaping Li*. A smart nanoassembly consisting of acid-labile vinyl ether PEG-DOPE and protamine for gene delivery: preparation and in vitro transfection. Biomacromolecules 2008,9,3119-3126
266. Yu Gao, Zhenghong Xu, Shangwei Chen, Wangwen Gu, Lingli Chen, Yaping Li*. Arginine-chitosan/DNA self-assemble nanoparticles for gene delivery: In vitro characteristics and transfection efficiency. Int J Pharm 2008,359,241-246
267. Yongxin Yang, Zhenghong Xu, Shangwei Chen, Yu Gao, Wangwen Gu, Lingli Chen, Yuanying Pei, Yaping Li*. Histidylated cationic polyorganophosphazene/DNA self-assembled nanoparticles for gene delivery.Int J Pharm 2008, 353,277-282
Prior to 2007
268. Pengcheng Zhang, Lingli Chen, Wangwen Gu, Zhenghong Xu, Yu Gao, Yaping Li*. In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer’s disease. Biomaterials 2007, 28,1882-1888
269. Yu Gao, Wangwen Gu, Lingli Chen, Zhenghong Xu, Yaping Li*. A multifunctional nano device as non-viral vector for gene delivery: in vitro characteristics and transfection. J Control Release 2007,118,381-388
270. Wangwen Gu, Zhenghong Xu, Yu Gao, Lingli Chen, Yaping Li*. Transferrin-mediated PEGylated nanoparticles for delivery of DNA/PLL complexes. Nanotechnology 2006,17,4148-4155
271. Jun Huang, Huaqing Liu, Wangwen Gu, Zhou Yan, Zhenghong Xu, Yongxin Yang, Xinzu Zhu, Yaping Li*. A delivery strategy for rotenone microspheres in an animal model of Parkinson’s Disease. Biomaterials 2006,27,937-946
272. Zhenghong Xu, Wangwen Gu, Jun Huang, Hong Sui, Zhaohui Zhou, Yongxin Yang, Zhou Yan and Yaping Li*. In vitro and in vivo evaluation of actively targetable nanoparticles for paclitaxel delivery. Int J Pharm 2005,288,361-368
273. Yaping Li*, Manfred Ogris, Jaroslav Pelisek, Wolfgang Roedl. Stability and release characteristics of poly(D,L-lactide-co-glycolide) encapsulated CaPi-DNA coprecipitation. Int J Pharm 2004,269,61-70
274. Yaping Li*, Manfred Ogris, Ernst Wagner, Jaroslav Pelisek, Martina Ruffer, Nanoparticles bearing polyethylenglycol-couple transferrin as gene carriers: preparation and in vitro evaluation. Int J Pharm 2003,259,93-101
275. Yaping Li, Yuanying Pei*, Xianying Zhang, Zhouhui Gu, Zhaohui Zhou, Weifang Yuan, Jianjun Zhou, Jiahua Zhu, Xiujian Gao. PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and in vivo biodistribution in rats. J Control Release 2001,71,203-211
276. Yaping Li*, Yuanying Pei, Zhaohui Zhou, Xianying Zhang, Zhouhui Gu, Jian Ding, Jianjun Zhou, Xiujian Gao, PEGylated polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers. J Control Release 2001,71,287-296
277. Yaping Li, Zhaohui Zhou, Yuanying Pei, Xianying Zhang, Zhouhui Gu, Weifang Yuan. PEGylated polyanoacrylate nanoparticles as salvicine carriers: sythesis, prepartion, and in vitro characterization. Acta Pharmacol Sin 2001,22,645-650
278. Yaping Li, Yuanying Pei, Jian Ding, Zuming Shen, Xianying Zhang, Zhouhui Gu, Jianjun. Zhou. PEGylated recombinant human tumor necrosis factor alpha: preparation and anti-tumor potency. Acta Pharmacol Sin 2001,22,549-555
279. Yaping Li*, Yuanying Pei, Zhaohui Zhou, Xianying Zhan, Zhouhui Gu, Jian Ding, Xiujian Gao and Jianhua Zhu. PEGylated Recombinant Human Tumor Necrosis Factor Alpha: Pharmacokinetics and Anti- tumor Effects. Biol Pharm Bull. 2001,24 ,666-670
280. Yaping Li*, Yuanying Pei, Zhaohui Zhou, Xianying Zhang, Zhouhui Gu, Jian Ding, Jianjun Zhou, Xiujian Gao and Jianhua Zhu. Stealth Polycyanoacrylate Nanoparticles as Tumor Necrosis Factor-α Carriers: Pharmacokinetics and Anti-tumor Effects. Biol Pharm Bull. 2001, 24,662-665
281. Yaping Li, Xianying Zhang, Jianjun Zhou, Yuanying Pei, Pharmacokinetics of intragastric ipriflavone solid dispersion in rats. Acta Pharmacol Sin 1999, 20,1035-1038
282. Yaping Li, Xianying Zhang, Jianjun Zhou, Yuanying Pei, Preparation and dissolution property of ipriflavone solid dispersion. Acta Pharmacol Sin 1999,20,957-960
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