Shanghai Institute of Material Medical Chinese Academy of Sciences

Biography

YANG Dehua obtained his Ph.D. degree from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences in 2009 followed by postdoctoral training at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. After joining Shanghai Institute of Materia Medica in 2012 as an associate professor, his work has mainly been directed towards structure and functional studies on class B G protein-coupled receptors, namely glucagon and glucagon-like peptide-1 receptors. He participated in the determination of the 3-D structures and conformational states of both receptors, as well as elucidation of their molecular mechanism for ligand-receptor selectivity. He was promoted to full professor in 2017.

EDUCATION

09/1997–07/2002, Yantai Normal College, B.S.

09/2002–07/2005, South China Normal University, M.S.

09/2005–12/2009, Shanghai Institutes for Biological Sciences, Ph.D.

WORK EXPERIENCE

1. 01/2010–02/2012, Shanghai Jiao Tong University School of Medicine. Postdoctoral Fellow

2. 02/2012–09/2012, Shanghai Institute of Materia Medica, CAS, Assistant Professor

3. 10/2012–09/2017, Shanghai Institute of Materia Medica, CAS, Associate Professor

4. 10/2017 till now, Shanghai Institute of Materia Medica, CAS, Professor

Research Directions

1. Structures and functions of G-protein coupled receptors (GPCRs)

2. High-throughput screening targeting GPCRs

3. Target discovery and validation for metabolic disease

Grants & Research Projects

National Natural Science Foundation of China (81973373, 2020.1-2023.12)

National Natural Science Foundation of China (81773792, 2018.1-2021.12)

National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program,” China (2018ZX09711002-002-005, 2018.1-2020.12)

National Natural Science Foundation of China (81573479, 2016.1-2019.12)

Strategic Priority Research Program of the Chinese Academy of Sciences (XDA12040308, 2016.1-2017.12)

National Natural Science Foundation of China (81373463, 2014.1-2017.12)

Novo Nordisk-CAS Research Foundation (No. NNCAS-2015-7, 2016.1-2017.12)

Achievements

1. Studies on the structures and functions of class B GPCRs

1) Study on the structure and function of GCGR.

2) Study on the structure and function of GLP-1R.

2. Molecular pharmacology of GPCRs

1) The conformational states and experimental validation of full-length GCGR.

2) The molecular determinants for ligand selectivity of both GCGR and GLP-1R.

3) The roles of a naturally occurring mutation V368M on GCGR-mediated glucose homeostasis and pancreatic functions.

3. High-throughput screening of small molecules targeting GPCRs

Establishing novel screening models and conducted the high-throughput screening targeting GLP-1R, GCGR and RXFP4.

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Social Titles

Managing Editor of Medicine in Drug Discovery

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Awards & Honors

1. 2016 Shanghai Talent Development Fund

2. 2017 SANOFI-SIBS Young Talent Scholarship

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Pubilcations

Full Publication List

Selected Publications

1. Fulai Zhou#; Huibing Zhang#; Zhaotong Cong#; Li-Hua Zhao#; Qingtong Zhou#; Chunyou Mao; Xi Cheng; Dan-Dan Shen; Xiaoqing Cai; Cheng Ma; Yuzhe Wang; Antao Dai; Yan Zhou; Wen Sun; Fenghui Zhao; Suwen Zhao; Hualiang Jiang; Yi Jiang; Dehua Yang*; H Eric Xu*; Yan Zhang*; Ming-Wei Wang*; Structural basis for activation of the growth hormone-releasing hormone receptor, Nature Communications, 2020, 11(1): 5205.

2. Guangyao Lin#; Qiaofeng Liu#; Antao Dai; Xiaoqing Cai; Qingtong Zhou; Xi Wang; Yan Chen; Chenyu Ye; Jie Li; Dehua Yang*; Ming-Wei Wang*; Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders, Biochemical Journal, 2020, 477(13): 2581-2594.

3. Haonan Zhang#; Anna Qiao#; Dehua Yang#; Linlin Yang#; Antao Dai; Chris de Graaf; Steffen Reedtz-Runge; Venkatasubramanian Dharmarajan; Hui Zhang; Gye Won Han; Thomas D Grant; Raymond G Sierra; Uwe Weierstall; Garrett Nelson; Wei Liu; Yanhong Wu; Limin Ma; Xiaoqing Cai; Guangyao Lin; Xiaoai Wu; Zhi Geng; Yuhui Dong; Gaojie Song; Patrick R Griffin; Jesper Lau; Vadim Cherezov; Huaiyu Yang; Michael A Hanson; Raymond C Stevens; Qiang Zhao; Hualiang Jiang*; Ming-Wei Wang*; Beili Wu*; Structure of the full-length glucagon class B G-protein-coupled receptor, Nature, 2017, 546(7657): 259-264.

4. Gaojie Song; Dehua Yang; Yuxia Wang; Chris de Graaf; Qingtong Zhou; Shanshan Jiang; Kaiwen Liu; Xiaoqing Cai; Antao Dai; Guangyao Lin; Dongsheng Liu; Fan Wu; Yiran Wu; Suwen Zhao; Li Ye; Gye Won Han; Jesper Lau; Beili Wu; Michael A Hanson; Zhi-Jie Liu*; Ming-Wei Wang*; Raymond C Stevens*; Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, Nature, 2017, 546(7657): 312-315.

5. Dehua Yang#; Chris de Graaf#; Linlin Yang#; Gaojie Song; Antao Dai; Xiaoqing Cai; Yang Feng; Steffen Reedtz-Runge; Michael A Hanson; Huaiyu Yang; Hualiang Jiang; Raymond C Stevens; Ming-Wei Wang*; Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R), Journal of Biological Chemistry, 2016, 291(25): 12991-13004.

6. Dehua Yang#; Qingtong Zhou#; Viktorija Labroska#; Shanshan Qin; Sanaz Darbalaei; Yiran Wu; Elita Yuliantie; Linshan Xie; Houchao Tao; Jianjun Cheng; Qing Liu; Suwen Zhao#; Wenqing Shui*; Yi Jiang*; Ming-Wei Wang*; G protein-coupled receptors: structure- and function-based drug discovery, Signal Transduction and Targeted Therapy, 2021, 6(1): 7.

7. Wen Sun#; Li-Nan Chen#; Qingtong Zhou#; Li-Hua Zhao#; Dehua Yang#; Huibing Zhang; Zhaotong Cong; Dan-Dan Shen; Fenghui Zhao; Fulai Zhou; Xiaoqing Cai; Yan Chen; Yan Zhou; Sarina Gadgaard; Wijnand J C van der Velden; Suwen Zhao; Yi Jiang; Mette M Rosenkilde; H Eric Xu*; Yan Zhang*; Ming-Wei Wang*; A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor, Cell Research, 2020, 30(12): 1098-1108.

8. Anna Qiao#; Shuo Han#; Xinmei Li#; Zhixin Li#; Peishen Zhao#; Antao Dai; Rulve Chang; Linhua Tai; Qiuxiang Tan; Xiaojing Chu; Limin Ma; Thor Seneca Thorsen; Steffen Reedtz-Runge; Dehua Yang; Ming-Wei Wang; Patrick M Sexton; Denise Wootten*; Fei Sun*; Qiang Zhao*; Beili Wu*; Structural basis of Gs and Gi recognition by the human glucagon receptor, Science, 2020, 367(6484): 1346-1352.

9. Guang-Yao Lin; Lin Lin; Xiao-Qing Cai; An-Tao Dai; Yue Zhu; Jie Li; Qing Liu; De-Hua Yang*; Ross A D Bathgate*; Ming-Wei Wang*; High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4, Acta Pharmacologica Sinica, 2020, 41(10): 1328-1336.

10. Qingtong Zhou#; Dehua Yang#; Meng Wu; Yu Guo; Wanjing Guo; Li Zhong; Xiaoqing Cai; Antao Dai; Wonjo Jang; Eugene I Shakhnovich; Zhi-Jie Liu; Raymond C Stevens; Nevin A Lambert; M Madan Babu*; Ming-Wei Wang*; Suwen Zhao*; Common activation mechanism of class A GPCRs, Elife, 2019, 8.

11. Fangping Wan#; Yue Zhu#; Hailin Hu#; Antao Dai; Xiaoqing Cai; Ligong Chen; Haipeng Gong; Tian Xia; Dehua Yang*; Ming-Wei Wang*; Jianyang Zeng*; DeepCPI: A Deep Learning-based Framework for Large-scale in silico Drug Screening, Genomics, Proteomics & Bioinformatics, 2019, 17(5): 478-495.

12. Shanshan Qin#; Mengmeng Meng#; Dehua Yang#; Wenwen Bai#; Yan Lu; Yao Peng; Gaojie Song; Yiran Wu; Qingtong Zhou; Suwen Zhao; Xiping Huang; John D McCorvy; Xiaoqing Cai; Antao Dai; Bryan L Roth; Michael A Hanson; Zhi-Jie Liu; Ming-Wei Wang*; Raymond C Stevens; Wenqing Shui*; High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening, Chemical Science (Royal Society of Chemistry: 2010), 2018, 9(12): 3192-3199.

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