Jia Xiao
CONTACT
jiaxiao@simm.ac.cn
0760-85286866
201203
555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China
Biography
Xiao Jia, Ph.D., Principal investigator of Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Dr Xiao Jia completed his BS and MS in chemistry at Shanghai University. In 2016, he joined the research group of Prof. Chris Meier at Hamburg University and obtained his PhD with summa cum laude. Afterwords, Dr Xiao Jia decided to stay in the same laboratory to continue his research on medicinal chemistry as a postdoctoral researcher in 2020-2024. Since April 2024, Dr Xiao Jia joined Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS), as a Professor and PI. His current research interests are mainly focused on antiviral and tumor nucleotide prodrugs.
Education Experience：
2016.10-2020.10 PhD degree, Universität Hamburg. Chemistry
2013.09-2016.06 Master degree, Shanghai University. Organic Chemistry
2009.09-2013.07 Bachelor degree, Shanghai University. Applied Chemistry
Work Experience：
2024.04- current, Researcher, Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
2020.10-2024.03 Postdoctoral fellow, Universität Hamburg.
Research Directions
Antiviral nucleotide chemistry: nucleoside analogues and nucleotide prodrugs.
Anti-tumor nucleotide prodrug research
Grants & Research Projects
Antiviral nucleotide chemistry
Achievements
1. Nucleoside diphosphate prodrugs (DiPPro-concept), with high chemical and biological stability, low cytotoxicity, and high anti-HIV activity.
2.Nucleoside triphosphate prodrugs (TriPPPro-concept) would bypass all steps of intracellular phosphorylation and maximize the intracellular concentration of the ultimately bioactive nucleoside analogue triphosphates.
3. Nucleoside tetraphosphate prodrugs (TetraPPPPro-concept) efficiently enter cells and deliver the corresponding nucleoside tetraphosphate analogues with high selectivity by chemical or enzymatic means.
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Social Titles
1. Member of Chinese Pharmaceutical Association 2.. Member of Chinese Chemical Society
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Awards & Honors
In 2015, "National Scholarship" for postgraduate students of Shanghai University.
In 2016, the second postgraduate "Academic Rising Star" Award of Shanghai University.
In 2020, Excellent doctoral graduate of Hamburg University, Excellent graduation thesis (awarded: Summary Cum laude).
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Pubilcations
Full Publication List
Selected Publications
1. Jia, X.; Schols, D.; Meier, C. Antiviral Activity of Lipophilic Nucleoside Tetraphosphate Compounds. J. Med. Chem. 2024, 67, 2864-2883.
2. Jia, X.;# Kullik, G. A.;# Bufano, M.; Brancale, A.; Schols, D.; Meier, C. Membrane-permeable tenofovir-di- and monophosphate analogues. Eur. J. Med. Chem. 2024, 264, 116020.
3. Jia, X.; Schols, D.; Meier, C. Potent anti-HIV activity of alkyl-modified DiPPro-nucleotides. Small. Struct. 2024, 5，2300430.
4. Jia, X.; Schols, D.; Meier, C. Lipophilic nucleoside triphosphate prodrugs of anti-HIV active nucleoside analogs as potential antiviral compounds. Adv. Sci. 2023, 10, 2306021.
5. Jia, X.; Schols, D.; Meier, C. Pronucleotides of 2’,3’-dideoxy-2’,3’-didehydrothymidine as potent anti-HIV compounds. J. Med. Chem. 2023, 66, 12163-12184.
6. Jia, X.; Weber, S.; Schols, D.; Meier, C. Membrane permeable and bioreversibly modified prodrugs of nucleoside diphosphate-γ-phosphonates. J. Med. Chem. 2020, 63, 11990-12007.
7. Jia, X.; Schols, D.; Meier, C. Lipophilic triphosphate prodrugs of various nucleoside analogues. J. Med. Chem. 2020, 63, 6991-7007.
8. Jia, X.; Schols, D.; Meier, C. Anti-HIV-active nucleoside triphosphate prodrugs. J. Med. Chem. 2020, 63, 6003-6027.
9. Chen, H. F.;# Jia, X.;# Yu, Y. Y.;# Qian, Q.; Gong, H. G. Nickel-catalyzed reductive allylation of tertiary alkyl halides with allylic carbonates. Angew. Chem., Int. Edit. 2017, 56, 13103-13106.
10. Zhao, C.;# Jia, X.;# Wang, X.; Gong, H. G. Ni-catalyzed reductive coupling of alkyl acids with unactivated tertiary alkyl and glycosyl halides. J. Am. Chem. Soc. 2014, 136, 17645-17651.
11. Jia, X.; Zhao, C. L.; Meier, C. First and second generation nucleoside triphosphate prodrugs: TriPPPro-compounds for antiviral chemotherapy. Handbook of Chemical Biology of Nucleic Acids. 2023, 2237-2266.
12. Jia, X.; Ganter, B.; Meier, C. Improving properties of the nucleobase analogs T-705/T-1105 as potential antiviral. Annu. Rep. Med. Chem. 2021, 57, 1-47.
13. Jia, X.; Zhang, X.; Qian, Q.; Gong, H. G. Alkyl-aryl ketone synthesis via Ni-catalyzed reductive coupling of alkyl haides with aryl acids and anhydrides. Chem. Commun. 2015, 51, 10302-10305.
14. Zhao, C. L.; Jia, X.; Schols, D.; Balzarini, J.; Meier, C. γ-Non-symmetrically-dimasked TriPPPro-prodrugs as potential antivirals against HIV. ChemMedChem 2021, 16, 499-512.
15. Xue, W. C.; Jia, X.; Wang, X.; Tao, X. H.; Yin, Z. G.; Gong, H. G. Nickel-catalyzed formation of quaternary carbon centers using tertiary alkyl electrophiles. Chem. Soc. Rev. 2021, 40, 4162-4184.
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