
CONTACT
whuang@simm.ac.cn
21-54923155
200031
Life Science Research Building 320 Yueyang Road, Xuhui District, 200031
Dr. Huang Wei joined the Shanghai Institute of Materia Medica, Chinese Academy of Sciences in November 2023 and serves as its principal investigator. He obtained his Ph.D. from the Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, and subsequently conducted postdoctoral research at the Public Health Research Institute of Rutgers University and the Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health. As corresponding or first author, he has published multiple papers in journals such as Science, eLife, PLoS Neglected Tropical Diseases, Philosophical Transactions of the Royal Society B, and mBio. His work has been cited more than 1,700 times and featured in commentaries or news stories by Science, Nature Reviews Microbiology, CNN, CNBC, BBC, Financial Times, New York Times, and leading Chinese outlets including Bioon and ScienceNet.
Education Experience:
1.September 2008 – July 2014, University of Chinese Academy of Sciences, Ph.D. in Zoology
2.September 2004 – June 2008, Huazhong Agricultural University, B.S. in Bioengineering
Work Experience:
1.Oct 2023–present: Principal Investigator & Professor, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2.May 2019–Sep 2023: Research Associate, Johns Hopkins Bloomberg School of Public Health, USA
3.Oct 2015–May 2019: Postdoctoral Fellow, Johns Hopkins Bloomberg School of Public Health, USA
4.Nov 2014–Oct 2015: Postdoctoral Fellow, Public Health Research Institute, Rutgers University, USA
Our lab is dedicated to the study of mosquitoes, investigating their interactions with mosquito-borne pathogens such as Plasmodium or arboviruses, mosquito symbiotic bacteria, and humans. Building upon this foundation, our primary objectives include the development of strategies to combat mosquito-borne diseases. This encompasses the creation of preventive measures, vaccines, and pharmaceutical treatments for diseases transmitted by mosquitoes.
Our research team employs a combination of biochemistry and molecular biology techniques to delve into the following areas:
1. Development of strategies to prevent mosquito-borne diseases, which includes examining the role of symbiotic bacteria and genetically modified mosquitoes in disease control.
2. Investigation of the infection process involving mosquitoes, mammals, and other hosts by mosquito-borne pathogens, along with the exploration of host defense mechanisms.
3. Research aimed at the development of highly effective vaccines and therapeutic drugs to combat mosquito-borne pathogens.
4. Exploration of biological control strategies to reduce mosquito populations.
National High-Level Talent Program; National Natural Science Foundation of China (General Program); Key Sub-project Member, National Key R&D Program; Sub-project Leader, NSFC Innovative Research Group B Program; CAS Future Partnership Program; Shanghai Magnolia Talent Youth Project
1.Isolated, for the first time, the naturally occurring anti-malaria symbiont Delftia sp. and elucidated how it blocks Plasmodium transmission from mosquitoes to mammalian hosts; semi-field trials validated its practical potential for malaria control (Science, 2023).
2.Deployed the Q-system binary expression platform to safely and efficiently deliver anti-parasitic effectors in mosquitoes, and combined transgenic symbiotic bacteria to potently and safely suppress malaria transmission (eLife, 2022; Nature Communications, 2022).
3.Deciphered how different transcription factors of entomopathogenic fungi govern virulence and developmental processes (Environmental Microbiology, 2015; Journal of Biological Chemistry, 2015; Philosophical Transactions of the Royal Society B, 2019).
1.CAS “Triple-A” Outstanding Student
2.CAS Di’ao Scholarship
3.Best Poster Award, NIH-NIAID Plasmodium Annual Meeting, USA
Selected Publications
1.Huang, W#., Rodrigues, J., Bilgo, E., Tormo, J. R., Challenger, J. D., De Cozar-Gallardo, C., ... & Jacobs-Lorena, M. (2023). Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes. Science, 381(6657), 533-540. DOI: 10.1126/science.adf8141
2.Huang, W#., Vega-Rodriguez, J., Kizito, C., Cha, S. J., & Jacobs-Lorena, M. (2022). Combining transgenesis with paratransgenesis to fight malaria. eLife, 11, e77584. doi: 10.7554/eLife.77584
3.Huang, W*., Gao, Q., Fu, K., Tejo, R. P., Floeter-Winter, L. M., & Gutierrez, A. P. (2022). Host-microbe interaction and coevolution. Frontiers in Genetics, 13, 983158. https://doi.org/10.3389/fgene.2022.983158
4.Huang, W#., Cha, S. J., & Jacobs‐Lorena, M. (2022). New weapons to fight malaria transmission: A historical view. Entomological Research, 52(5), 235-240. doi: 10.1111/1748-5967.12585
5.Huang, W#., Wang, S., & Jacobs-Lorena, M. (2020). Self-limiting paratransgenesis. PLoS neglected tropical diseases, 14(8), e0008542. doi: 10.1371/journal.pntd.0008542
6.Huang, W#., Wang, S., & Jacobs-Lorena, M. (2020). Use of microbiota to fight mosquito-borne disease. Frontiers in genetics, 11, 196. doi:10.3389/fgene.2020.00196
7.Huang, W#., Hong, S., Tang, G., Lu, Y., & Wang, C. (2019). Unveiling the function and regulation control of the DUF3129 family proteins in fungal infection of hosts. Philosophical Transactions of the Royal Society B, 374(1767), 20180321. doi: 10.1098/rstb.2018.0321
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