1.Established multi-disciplinary platforms for dissecting the immune signaling pathways and functional characterization of both innate and adaptive immune cells.

2.Established muti-omics approaches for the investigation of metabolic and epigenetic regulation of immune responses.

3.Discovered novel mechanisms by which cellular metabolites regulate inter-organelle immune crosstalk.

4.Identified promising candidate molecules and strategies could be developed into novel cancer immunotherapy or vaccine regimen.

5.Employed high-throughput screen for the identification of key regulators determining immune cell memory formation or exhaustive conversion.

1.First Prize of the National Ministry of Education’s Natural Science Award (Ranked 4th), 2020

2.Excellent Doctoral Dissertation Supervisor of the Chinese Academy of Sciences (CAS), 2017

3.Outstanding Young Scientist Award (F. Merlin Bumpus Award) of Cleveland Clinic, 2007

1.Cao L., Wang L., Li Z., Wei X., Ding J., Zhou C., Chen X., Huang Z., Shao Z., Shen J., Lou H., Zhao K., Huang Y., Yang Y., Liu H., Sun Y., Niu J., Jiang S., Lu R., Tang L., Zhang X., Zhang H., Xiao Y., Chen J., Ma S., Gao C., Meng G., Li L., Qiu Z., Wang H., Deng L., Ye Y., Jia X., Li H.*, Xiao H*. Radiotherapy Enhances Anticancer CD8 T Cell Responses by cGAMP Transfer through LRRC8A/C Volume-Regulated Anion Channels. Science Immunology 2025 June 27. 10(108): eadn1630. *Corresponding authors

2.Shao Z, Wang L, Cao L, Chen T, Jia XM, Sun W*, Gao C*, Xiao H*. The protein segregase VCP/p97 promotes host antifungal defense via regulation of SYK activation. PLoS Pathog. 2024 Oct 29;20(10): e1012674. *Corresponding authors

3.Wang L, Cao L, Li Z, Shao Z, Chen X, Huang Z, He X, Zheng J, Liu L, Jia XM*, Xiao H*. ATP-elicited Cation Fluxes Promote Volume-regulated Anion Channel LRRC8/VRAC Transport cGAMP for Antitumor Immunity. J Immunol. 2024 Aug 1; 213(3):347-361. *Corresponding authors

4.Wu H, Wang L, Wang W, Shao Z, Jia XM, Xiao H*, Chen J*. The secretory Candida effector Sce1 licenses fungal virulence by masking the immunogenic β-1,3-glucan and promoting apoptosis of the host cells. mLife. 2023 Jun 26;2(2):159-177. *Corresponding authors

5.Chen X, Wang L, Cao L, Li T, Li Z, Sun Y, Ding J, Zhou C, Xie Y, Yue N, Nan J, Jia XM, Peng C, Li H, Yang J*, Xiao H*. Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2'3'-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation. J Immunol. 2021 May 1;206(9):2061-2074. *Corresponding authors

6.Zhou C, Chen X, Planells-Cases R, Chu J, Wang L, Cao L, Li Z, López-Cayuqueo KI, Xie Y, Ye S, Wang X, Ullrich F, Ma S, Fang Y, Zhang X, Qian Z, Liang X, Cai SQ, Jiang Z, Zhou D, Leng Q, Xiao TS, Lan K, Yang J, Li H, Peng C, Qiu Z*, Jentsch TJ*, Xiao H*. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 May 19; 52: 767-781. *Corresponding authors

7.Xie Y, Zhao Y, Shi L, Li W, Chen K, Li M, Chen X, Zhang H, Li T, Yu MI, Yao X, Shao D, Ke Z, Li J, Chen Y, Zhang X, Cui J, Cui S, Leng Q, Cadwell K, Li X, Wei H, Zhang H, Li H*, Xiao H*. Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. J Clin Invest. 2020 Apr 1;130(4):2111-2128. *Corresponding authors

8.Shi L, Chen X, Zang A, Li T, Hu Y, Ma S, Lü M, Yin H, Wang H, Zhang X, Zhang B, Leng Q*, Yang J*, Xiao H*. TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. PLoS Biol. 2019 Aug 21;17(8): e3000420. *Corresponding authors

9.Wang W, Deng Z, Wu H, Zhao Q, Li T, Zhu W, Wang X, Tang L, Wang C, Cui SZ, Xiao H*, Chen J*. A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection. Nat Commun. 2019, Mar 4;10(1):1015. *Corresponding authors

10.Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, Zhou C, Fang Y, Liu J, Yang J, Chen X, Li T, Zang A, Yin S, Li B, Plumas J, Chaperot L, Zhang X, Xu G, Jiang L, Shen N, Xiong S, Gao X, Zhang Y, Xiao H*. Epigenetic regulator CXXC5 recruit DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017, 214(5):1471-1491. *Corresponding author

11.Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H*. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015,16:642-652. *Corresponding author

12.He L, Zang A, Du M, Ma D, Yuan C, Zhou C, Mu J, Shi H, Li D, Huang H, Deng Q, Xiao J, Yan H, Hui L, Lan K, Xiong S, Li X, Huang Z, Xiao H*. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virologica Sinica. 2015, 30:1-16. *Corresponding author

13.Xiao H#, Yin W, Khan M, Gulen MF, Zhou H, Sham HP, Jacobson K, Vallance BA and Li X. Loss of SIGIRR leads to enhanced colonic polyposis in Apcmin mice. Gastroenterology 2010, 139:574-585. #First author

14.Xiao H#, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Walde D, Ma C, Zhou H, Tuohy VK, Fairchild R, de la Motte C, Cua D, Vallance BA, and Li X. The Toll-Interleukin-1 receptor member SIGIRR regulates colonic epithelia homeostasis, inflammation and tumorigenesis. Immunity 2007, 26:461-75.     #First author