Researchers Develop Annotation Approach for Endogenous Retroviruses and Reveal Their Divergent Evolution Across Species

In a study published in Science Advances, a team of researchers led by CHEN Xun from the Institute, Guillaume Bourque and Fumitaka Inoue from Kyoto University, Japan developed a novel phylogeny-based approach for the classification and annotation ...

2025-07-22 All →

PNAS｜Cryo-EM Structures Reveal How GnRH Activates Its Receptor, Opening Pathways for New Therapies

In a study published in PNAS, a team led by DUAN Jia and XU Huaqiang (H. Eric XU) from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, reported high-resolution cryo-electron microscopy (cryo-EM) structures of GnRHR fro...

2025-06-17 All →

Researchers Disrupt cGAS-DNA Phase Separation by De Novo Design of Allosteric Inhibitors: A Potential Therapeutic Strategy

In a study published in Nature Communications, a research team led by XU Yechun from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences (CAS) reported the discovery of an allosteric site adjacent to cGAS’s activati...

2025-06-11 All →

Researchers Develop Tracheal Targeted Nanogrid Drug Delivery Systems Visualized by Three-dimensional Pathological Mapping

In a study published in ACS Nano, a research team led by YIN Xianzhen from the Lingang Laboratory and ZHANG Jiwen from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences (CAS), reported the development of a precise ...

2025-06-11 All →

NMRExtractor: Leveraging Large Language Models to Construct an Experimental NMR Database from Open-source Scientific Publications

In this work, the researchers developed NMRExtractor by fine-tuning Mistral-7B-instruct LLM on a curated dataset of human-annotated NMR examples. The model was optimized to interpret complex textual descriptions of NMR results in open-access PubMe...

2025-06-04 All →

Researchers Reveal Structural Basis of Prostaglandin D2 Receptor DP1 Activation and Its Implications for Drug Design

Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative anti-inflammatory and immunomodulatory therapies. DP1, a G protein-coupled receptor (GPCR), plays a key role in mediating allergic...

2025-05-30 All →