3D Channel Maze, New Mechanism to Control Drug Release from Multiple Unit Tablets

Synchrotron radiation3D channel mazemechanism.Contact:JIANG QinglingShanghai Institute of Materia Medica, Chinese Academy of SciencesE-mail:qljiang@stimes.cn.

2024-12-26 All →

Scientists Establish integrative Proteogenomic and Pharmacological Landscape of Acute Myeloid Leukaemia in Chinese Population

Acute myeloid leukaemiais mainly characterized by an increase in myeloid cells in bone marrow and a decrease in mature cells, accounting for 28% of leukaemia cases, with a five-year survival rate of only 30.5%.

2024-12-19 All →

Researchers Uncover Molecular Mechanisms of Lipid and Ligand Regulation in Prostaglandin Receptor DP2

In a study published in PNAS on December 12, a research team led by Eric H. Xu (XU Huaqiang) and WU Canrong from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences, presented cryo-electron microscopy (cryo-EM) struc...

2024-12-13 All →

Novel Nanovesicle May Improve Immunochemotherapy for TNBC

Interleukin 15 (IL15) is a key cytokine for promoting survival and proliferation of natural killer (NK) cells and CD8+ T cells. However, IL15 based supplementary therapies face challenges such as systemic inflammation and nonspecific stimulation o...

2024-12-09 All →

Conformation Influences Biological Fates of Peptide-Based Nanofilaments

In nature, numerous biological structures with distinct shapes are generated through self-assembly. Unlike spherical particles, biological nanofilaments such as microtubules and collagen leverage their specificity and multivalent binding capabilit...

2024-12-09 All →

Nuclear GTPSCS Identified as Lactyl-CoA Synthetase Promoting Histone Lactylation and Gliomagenesis

Lactate, a key product of glycolysis in mammals, is markedly elevated in pathological conditions such as tumors, sepsis, and autoimmune diseases, a phenomenon known as the Warburg effect.

2024-12-06 All →