Scientists Unveil an Oral Drug Candidate VV261 against Chikungunya Virus

Chikungunya virus (CHIKV) is a mosquito-borne, positive-sense RNA virus that causes high fever and severe joint pain. Since 2004, CHIKV outbreaks have become more frequent and widespread. In July 2025, Guangdong province in China reported more tha...

2026-03-05 All →

Researchers Design an Opioid Receptor Modulator That Strengthens Morphine Analgesia at Lower Doses

Pain, especially moderate to severe chronic pain, remains a major clinical problem. Opioid drugs are still widely used because they provide strong and fast pain relief. But their benefits come with serious costs, including respiratory depression, ...

2026-03-02 All →

Researchers Develop a Dual-Payload Design for Targeted Cancer Therapy with Enhanced Safety

Small-molecule drug conjugates (SMDCs) are an emerging targeted cancer therapy platform with great potential. However, traditional single-payload designs have critical limitations in delivery efficiency, bystander activity and safety profile, whic...

2026-02-28 All →

New Tools Decode the Function of a Ketone-Driven Protein Modification

Protein post-translational modifications (PTMs) expand the functional diversity of the proteome well beyond what is encoded in the genome. By regulating protein activity, localization, stability, and molecular interactions, PTMs participate in vir...

2026-02-27 All →

Researchers Identify the “Northwest Passage” Mechanism of Bile Acid Transport

Bile acids are essential for digestion, metabolism, and hormonal signaling. Their circulation between the liver and intestine, known as the enterohepatic circulation, depends on a coordinated network of membrane transporters. Most of these transpo...

2026-01-29 All →

Researchers Develop a Versatile Bioorthogonal Theranostic Platform for Precision Cancer Therapy

Targeted protein degradation (TPD) has revolutionized drug discovery by enabling selective elimination of previously ‘undruggable’ proteins through molecular glue degraders (MGDs) and proteolysis-targeting chimeras (PROTACs). Despite this promis...

2026-01-15 All →