Researchers Identify the “Northwest Passage” Mechanism of Bile Acid Transport

Bile acids are essential for digestion, metabolism, and hormonal signaling. Their circulation between the liver and intestine, known as the enterohepatic circulation, depends on a coordinated network of membrane transporters. Most of these transpo...

2026-01-23 All →

Researchers Develop a Versatile Bioorthogonal Theranostic Platform for Precision Cancer Therapy

Targeted protein degradation (TPD) has revolutionized drug discovery by enabling selective elimination of previously ‘undruggable’ proteins through molecular glue degraders (MGDs) and proteolysis-targeting chimeras (PROTACs). Despite this promis...

2026-01-15 All →

Study Develops Human-Derived AMBER Editor for Efficient C-to-U RNA Editing in vivo

In a study published in National Academy of Sciences of the United States of America (PNAS), a research team led by HAO Pei from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and LI Xuan from the Center for Excellence in M...

2025-12-10 All →

Researchers Decode Selective and Dual Blocking of Prostaglandin Receptors EP2 and EP4

Prostaglandin E2 (PGE2), a key lipid mediator, drives inflammation, pain, and cancer progression by activating four G protein-coupled receptors (GPCRs): EP1–EP4. Among these, EP2 and EP4 receptors critically shape the immunosuppressive tumor micr...

2025-12-09 All →

Chemerin Receptor Structures Disclose New Lipid Metabolism Mechanism

Chemerin is a key adipokine—a signaling protein released by adipose tissue—that regulates lipid metabolism and insulin sensitivity and thus is involved in many metabolic diseases such as obesity and diabetes. It also plays a critical role in inf...

2025-11-21 All →

The Sixth Annual Conference of Pan-Balkan Alliance of Natural Products and Drug Discovery Associations and the 2025 Seminar of UNESCO Regional Network of Natural Products Chemistry held at SIMM, CAS

The Sixth Annual Conference of Pan-Balkan Alliance of Natural Products and Drug Discovery Associations and the 2025 Seminar of UNESCO Regional Network of Natural Products Chemistry was held at the Niudun Road new campus of SIMM from October 26 to ...

2025-11-06 All →