Study Develops Human-Derived AMBER Editor for Efficient C-to-U RNA Editing in vivo

In a study published in National Academy of Sciences of the United States of America (PNAS), a research team led by HAO Pei from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and LI Xuan from the Center for Excellence in M...

2025-12-10 All →

Researchers Decode Selective and Dual Blocking of Prostaglandin Receptors EP2 and EP4

Prostaglandin E2 (PGE2), a key lipid mediator, drives inflammation, pain, and cancer progression by activating four G protein-coupled receptors (GPCRs): EP1–EP4. Among these, EP2 and EP4 receptors critically shape the immunosuppressive tumor micr...

2025-12-09 All →

Chemerin Receptor Structures Disclose New Lipid Metabolism Mechanism

Chemerin is a key adipokine—a signaling protein released by adipose tissue—that regulates lipid metabolism and insulin sensitivity and thus is involved in many metabolic diseases such as obesity and diabetes. It also plays a critical role in inf...

2025-11-21 All →

The Sixth Annual Conference of Pan-Balkan Alliance of Natural Products and Drug Discovery Associations and the 2025 Seminar of UNESCO Regional Network of Natural Products Chemistry held at SIMM, CAS

The Sixth Annual Conference of Pan-Balkan Alliance of Natural Products and Drug Discovery Associations and the 2025 Seminar of UNESCO Regional Network of Natural Products Chemistry was held at the Niudun Road new campus of SIMM from October 26 to ...

2025-11-06 All →

Researchers Unveiled Conformation-Selective “Valve Model” for Norepinephrine Transporter Regulation

In a study published in Cell, researchers from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences and the Lingang Laboratory, together with collaborators, have unveiled a conformation-selective allosteric regulation mechanism of...

2025-10-29 All →

Researchers Reveal Dual-Target Mechanism of New Drug BGT-002 for Treating Metabolic Dysfunction-Associated Steatohepatitis

In a study published in Cell Metabolism, a research team led by LI Jingya, NAN Fajun from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, in collaboration with DING Yanhua from Jilin University and other partners, repo...

2025-10-23 All →