Study Decodes Cell Membrane Sphingolipid Remodeling: A Novel Therapeutic Pathway for advanced MASH

Metabolic dysfunction-associated steatohepatitisis a chronic liver disease initiated by excessive lipid accumulation, triggering inflammation, hepatocyte ballooning, and fibrotic remodeling.

2025-02-28 All →

Study Decodes Mechanisms of Coral-derived Biflorane Terpene Synthase

Bifloranes, also known as serrulatanes, feature a distinct 6, 6-bicyclic framework and a prenyl side chain, showcasing a wide range of biological activities such as anti-inflammatory, antimalarial, and antitumor effects.

2025-02-27 All →

Researchers Develop Augmented Sonoimmunotherapy for Solid Tumors

Link:https://doi.org/10.1002/adma.202413289 Title:Cryo-Shocked Tumor-Reprogrammed Sonosensitive Antigen-Presenting Cells Improving Sonoimmunotherapy via T Cells and NK Cells ImmunityKeywords:Tumor cell reprogramming, Sonoimmunotherapy.

2025-02-25 All →

Researchers Uncover Assembly and Architecture of Endogenous NMDA Receptors in Adult Cerebral Cortex and Hippocampus

Learning and memory are fundamental brain functions that underlie human cognition and perception of the world, which rely on development- and activity-dependent synaptic plasticity. N-methyl-ᴅ-aspartate (NMDA) receptors, members of excitatory ion...

2025-01-24 All →

Meet Injectable Supramolecular Hydrogel of Abemaciclib-Loaded Peptide-NLG919 Nanofibers for Neoadjuvant Immunotherapy of Triple-Negative Breast Cancer

The efficacy of immunotherapy against triple-negative breast cancer (TNBC) heavily relies on intratumoral infiltration of cytotoxic T lymphocytes (CTLs). Although the neoadjuvant chemotherapy together with immunotherapy has been approved for advan...

2025-01-22 All →

Engineered Extracellular Vesicles Loaded in Boronated Cyclodextrin Framework: Novel Design for Pulmonary Delivery

Given that BCF was synthesized from cyclodextrins, BCF was an ideal delivery carrier for small molecule drugs. Additionally, the amphipathic nature of EVs’membrane provided a versatile platform for transporting both hydrophobic and hydrophilic mo...

2024-12-30 All →