Researchers Reveal Structural Basis of Prostaglandin D2 Receptor DP1 Activation and Its Implications for Drug Design

Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative anti-inflammatory and immunomodulatory therapies. DP1, a G protein-coupled receptor (GPCR), plays a key role in mediating allergic...

2025-05-30 All →

Researchers Design Novel Reaction Description Language for Encoding Molecular Editing Operations in Chemical Reactions

Artificial intelligence technologies, represented by large language models (LLMs), have achieved unprecedented breakthroughs in natural language processing, influencing paradigm of scientific research. In the fields of chemistry and pharmaceutical...

2025-05-19 All →

Researchers Reveal Activation Mechanism of Prostaglandin E₂ Receptor EP1

In a study published in PNAS on May 15, a research team led by Eric H. Xu (XU Huaqiang) and XU Youwei from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, reported cryo-electron microscopy (cryo-EM) structure of the hu...

2025-05-15 All →

Researchers Circumvent “On-Target Apoptotic Toxicity” in RIPK3 Inhibitors via Conformational Regulation Strategy

RIPK3 is a key kinase that drives necroptosis—a programmed, pro-inflammatory form of cell death implicated in conditions such as sepsis, viral pneumonia, and neurodegenerative diseases. Owing to its central role in this pathway, RIPK3 has attract...

2025-05-14 All →

Scientists Discover Residue-Selective Inhibitors via Covalent DNA-Encoded Chemical Library Selection with Diverse Warheads

Covalent drugs specifically target key cancer sites by forming covalent bonds with residues on the targets, making them important strategies for precision cancer therapy.

2025-05-12 All →

Hedgehog-Interacting Protein Drives Lung Maturation and Confers Resistance to Chronic Respiratory Diseases

The study demonstrated that administration of recombinant HHIP protein in mouse models not only mitigates hallmark features of neonatal BPD but also prevents later development of COPD/emphysema changes in adulthood, positioning HHIP as both a key ...

2025-05-08 All →