Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Inhibitor designFirst-in-class inhibitor design based on the first crystal structure of MPXV I7L proteaseContact:JIANG QinglingShanghai Institute of Materia Medica, Chinese Academy of SciencesE-mail:qljiang@stimes.cn.

2025-04-11 All →

Study Identifies Structural Basis of CysLT2R Activation by LTD4

And CysLT1/2R.Cryo-EM density map of LTD4-CysLT2R-G α q complex.Structural model determined after refinement in the cryo-EM map and LTD4 density map.LTD4 chemical formula.LTD4 binding pocket of CysLT2R.Sliced surface representation of the LTD4-bi...

2025-04-09 All →

Researchers Discover Covalent ALKBH5 Inhibitor with Novel Mechanism Against Leukemia

As an emerging field of RNA epigenetics in molecular biology, m6A modification has been shown to affect transcription and expression of key pathogenic gene sets in various diseases.

2025-03-10 All →

Study Decodes Cell Membrane Sphingolipid Remodeling: A Novel Therapeutic Pathway for advanced MASH

Metabolic dysfunction-associated steatohepatitisis a chronic liver disease initiated by excessive lipid accumulation, triggering inflammation, hepatocyte ballooning, and fibrotic remodeling.

2025-02-28 All →

Study Decodes Mechanisms of Coral-derived Biflorane Terpene Synthase

Bifloranes, also known as serrulatanes, feature a distinct 6, 6-bicyclic framework and a prenyl side chain, showcasing a wide range of biological activities such as anti-inflammatory, antimalarial, and antitumor effects.

2025-02-27 All →

Researchers Develop Augmented Sonoimmunotherapy for Solid Tumors

Link:https://doi.org/10.1002/adma.202413289 Title:Cryo-Shocked Tumor-Reprogrammed Sonosensitive Antigen-Presenting Cells Improving Sonoimmunotherapy via T Cells and NK Cells ImmunityKeywords:Tumor cell reprogramming, Sonoimmunotherapy.

2025-02-25 All →