ROS-responsive Cyclodextrin Supramolecular Nanoparticles for Precise Treatment of Colitis

Ulcerative colitisis a chronic and recurrent inflammatory disease impacting rectum and colon, with its prevalence surging in emerging industrialized nations and currently lacking a cure.

2024-09-26 All →

New AI tool efficiently deconvolutes compound-protein interactions

Compounds and proteins are the two most fundamental entities in drug discovery. Modeling their interactions is crucial for drug discovery and represents a shared goal among researchers. Although no universal computational method currently exists t...

2024-09-23 All →

Direct Cytosolic Delivery of siRNA via Cell Membrane Fusion Using Cholesterol-Enriched Exosomes

RNA interferencetechnology has gradually become a cutting-edge technology for treating major diseases, such as genetic disorders and cancer, due to its huge potential in gene expression regulation.

2024-09-20 All →

Prebiotic Carrier Assists Regorafenib in Treating Colorectal Cancer

Colorectal cancer (CRC) is one of the most diagnosed and mortal cancers worldwide. Regorafenib (REG), a small-molecule multi-pathway protein kinase inhibitor, was approved by the FDA in 2017 to treat metastatic CRC. Due to the poor water solubilit...

2024-09-09 All →

Innovative Strategy Develops Liver-Targeting Chimeras for Liver Disease Treatment

Liver cancer ranks as the fourth most common cancer and the second leading cause of cancer-related deaths in China, with hepatocellular carcinomabeing the most prevalent type.

2024-09-06 All →

TranSiGen: Novel Deep Generative Model for Phenotype-based Drug Screening

Phenotype-based screening is crucial for drug discovery , focusing on comprehensive cellular responses to drug candidates .Including ligand-based virtual screening , drug response prediction , and phenotype-based drug repurposing .Demonstrated the...

2024-06-28 All →