Researchers Discover Potent Oral Sialylation Inhibitor That Enhances Immunotherapy for Pancreatic Ductal Adenocarcinoma

In a study published in ACS Central Science, a research team led by YU Biao from the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, and GONG Likun from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, d...

2025-10-14 All →

Ultrasound-Activatable Lipid Nanoparticle for Improved mRNA Vaccine Cancer Therapy

In a study published in Journal of Controlled Release, a research team led by ZHANG Jiwen from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences used ectoine, a natural stabilizer, to preserve milk-derived EVs (mEVs) through ly...

2025-10-11 All →

Lyophilization Technique Stabilizes Extracellular Vesicles for Effective Dry Eye Treatment

Dry eye disease (DED) is a common condition that affects millions of people worldwide, leading to ongoing eye discomfort and blurred vision. Although extracellular vesicles (EVs) have shown potential as a treatment, their clinical use has been hin...

2025-08-29 All →

Shanghai Institute of Materia Medica Conducts Nucleic Acid Drug Research Aboard China's Space Station

On July 15, 2025, the experimental materials for the project "Study on Biological Functions of Nucleic Acid Lipid Nanocarriers in Microgravity Environment", led by GAN Yong's Lab at the Shanghai Institute of Materia Medica, were delivered to the ...

2025-08-29 All →

Nature Ecology & Evolution | Researchers Discover That “Less Is More”: Gene Loss Drives Adaptative Evolution in a Pandemic Pathogen

In a study published in Nature Ecology & Evolution, Daniel FALUSH and YANG Chao's team from the Institute of the Chinese Academy of Sciences, along with Jaime MARTINEZ-URTAZA's team from Universitat Autònoma de Barcelona and WANG Hui' team from S...

2025-08-29 All →

Groundbreaking Whole-Brain Imaging Reveals Glioma Heterogeneity and Vascular Disruption

Glioma, one of the most aggressive brain tumors, exhibits significant spatial and temporal heterogeneity, especially in its vasculature. This complexity has long hindered effective drug delivery and treatment outcomes. Traditional imaging techniqu...

2025-08-22 All →