Headline
-
Researchers Uncover Assembly and Architecture of Endogenous NMDA Receptors in Adult Cerebral Cortex and Hippocampus
Learning and memory are fundamental brain functions that underlie human cognition and perception of the world, which rely on development- and activity-dependent synaptic plasticity. N-methyl-ᴅ-aspartate (NMDA) receptors, members of excitatory ion...
2025-01-24 All →
-
Meet Injectable Supramolecular Hydrogel of Abemaciclib-Loaded Peptide-NLG919 Nanofibers for Neoadjuvant Immunotherapy of Triple-Negative Breast Cancer
The efficacy of immunotherapy against triple-negative breast cancer (TNBC) heavily relies on intratumoral infiltration of cytotoxic T lymphocytes (CTLs). Although the neoadjuvant chemotherapy together with immunotherapy has been approved for advan...
2025-01-22 All →
-
Engineered Extracellular Vesicles Loaded in Boronated Cyclodextrin Framework: Novel Design for Pulmonary Delivery
Given that BCF was synthesized from cyclodextrins, BCF was an ideal delivery carrier for small molecule drugs. Additionally, the amphipathic nature of EVs’membrane provided a versatile platform for transporting both hydrophobic and hydrophilic mo...
2024-12-30 All →
-
3D Channel Maze, New Mechanism to Control Drug Release from Multiple Unit Tablets
Synchrotron radiation3D channel mazemechanism.Contact:JIANG QinglingShanghai Institute of Materia Medica, Chinese Academy of SciencesE-mail:qljiang@stimes.cn.
2024-12-26 All →
-
Scientists Establish integrative Proteogenomic and Pharmacological Landscape of Acute Myeloid Leukaemia in Chinese Population
Acute myeloid leukaemiais mainly characterized by an increase in myeloid cells in bone marrow and a decrease in mature cells, accounting for 28% of leukaemia cases, with a five-year survival rate of only 30.5%.
2024-12-19 All →
-
Researchers Uncover Molecular Mechanisms of Lipid and Ligand Regulation in Prostaglandin Receptor DP2
In a study published in PNAS on December 12, a research team led by Eric H. Xu (XU Huaqiang) and WU Canrong from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences, presented cryo-electron microscopy (cryo-EM) struc...
2024-12-13 All →