Hedgehog-Interacting Protein Drives Lung Maturation and Confers Resistance to Chronic Respiratory Diseases

The study demonstrated that administration of recombinant HHIP protein in mouse models not only mitigates hallmark features of neonatal BPD but also prevents later development of COPD/emphysema changes in adulthood, positioning HHIP as both a key ...

2025-05-08 All →

Researchers Decode Neuronal CCL2 as Key Bridge Between Diabetes and Mental Disorders

This study is the first to identify chemokine CCL2 in neurons as a key driver of anxiety behavior in the diabetic context, providing a novel perspective on the pathogenesis of diabetes-associated mental disorders.

2025-05-07 All →

Study Reveals Metabolic Impact and Clinical Relevance of Intact N-Glycosylation in Colorectal Cancer

Colorectal canceris a leading global malignancy, with tumor progression driven by complex metabolic reprogramming, including aberrant N-glycosylation patterns that play a pivotal role in tumor development.

2025-04-29 All →

Self-Assembling Glycopeptide Defeats Superbugs by Disrupting Cell Structures and Virulence Pathways

Antimicrobial resistancerepresents an escalating global health crisis, responsible for an estimated 1.27 million deaths directly caused by resistant infections in 2019 and nearly 5 million deaths associated with AMR.

2025-04-21 All →

Scientists Discover Lysine-Targeting Covalent Inhibitors via DNA-Encoded Chemical Library Selection Platform Guided by Proteome-Wide Data

Covalent drugs function by forming covalent bonds with specific amino acid residues, enabling sustained modulation of target proteins.

2025-04-21 All →

Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Inhibitor designFirst-in-class inhibitor design based on the first crystal structure of MPXV I7L proteaseContact:JIANG QinglingShanghai Institute of Materia Medica, Chinese Academy of SciencesE-mail:qljiang@stimes.cn.

2025-04-11 All →