Chinese Scientists Uncover Structural Basis for SARS-CoV-2 Inhibition by Remdesivir

A team of Chinese scientists have reported the high-resolution cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2 , the infective virus of COVID-19 . The research , published online in Science on May 1 .The overall conform...

2020-05-01 All →

Chinese Scientists Determine Structural Basis for Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

2020-04-30 All →

Oligomannate Obtains IND Approval from US FDA for International Phase III Clinical Study

According to Shanghai Green Valley Pharmaceuticals ( Green Valley ) .Green Valley received the formal decision letter from the US Food and Drug Administration ( FDA ) on the Investigational New Drug ( IND ) application for the GV-971 international...

2020-04-28 All →

Structure-Based Design of Antiviral Drug Candidates Targets SARS-CoV-2 Main Protease

A team of Chinese scientists has recently developed two novel compounds that inhibit the SARS-CoV-2 main protease ( Mpro ) and one of them is a good drug candidate for further clinical studies .High-resolution analysis of complexes is useful to me...

2020-04-22 All →

Chinese Scientists Determine Structure of COVID-19 Main Protease and Identify Inhibitors

Recently, Prof. RAO Zihe and Prof. YANG Haitao from the Shanghai Institute for Advanced Immunochemical Studies of ShanghaiTech University, Prof. JIANG Hualiang from the Shanghai Institute of Materia Medica of Chinese Academy of Sciences, together ...

2020-04-10 All →

Glucagon Receptor Structures Reveal G protein Specificity Mechanism

G protein-coupled receptors ( GPCRs ) play essential roles in cell signal transduction and serve as important therapeutic targets for a large number of diseases .Upon binding to extracellular agonists , GPCRs stimulate various signaling pathways b...

2020-03-16 All →