Structural Basis for InhStructural Basis for Inhibiting HBV via HBx–Smc6 Interface: A New Therapeutic Directionibiting HBV via HBx–Smc6 Interface: A New Therapeutic Direction

Chronic hepatitis B virus (HBV) infection remains a major global health challenge, affecting approximately 250 million people worldwide, with about 80 million in China. Chronic ...

Researchers Enable Small-Molecule-Mediated Precision Protein Editing in Living Cells

While genome editing technologies have revolutionized biology, a key gap remains: the lack of methods for direct, site-specific single amino acid editing in endogenous proteins....

Scientists Discover that IL-22 Supports Long-Term Expansion of Mouse and Human Hepatocytes

Hepatocytes have wide applications in drug development, disease modeling, and cell therapy. However, expanding hepatocytes in large quantities in vitro without compromising thei...