Researchers Reveal Activation Mechanism of Prostaglandin E₂ Receptor EP1

In a study published in PNAS on May 15, a research team led by Eric H. Xu (XU Huaqiang) and XU Youwei from the Shanghai Institute of Materia Medica of the Chinese Academy of Sci...

Researchers Circumvent “On-Target Apoptotic Toxicity” in RIPK3 Inhibitors via Conformational Regulation Strategy

RIPK3 is a key kinase that drives necroptosis—a programmed, pro-inflammatory form of cell death implicated in conditions such as sepsis, viral pneumonia, and neurodegenerative ...

Scientists Discover Residue-Selective Inhibitors via Covalent DNA-Encoded Chemical Library Selection with Diverse Warheads

Covalent drugs specifically target key cancer sites by forming covalent bonds with residues on the targets, making them important strategies for precision cancer therapy.