On March 8, 2023, the National Medical Products Administration (NMPA) of China conditionally approved Gumarontinib fo...
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Researchers Reveal Dynamic Regulation of Ubiquitin Ligase E6AP Activity
E6AP , the founding member of the HECT-type ubiquitin ligase family , was initially discovered for its interaction with the oncogenic protein E6 of human papillomavirus ( HPV ) ...
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Spatiotemporal and Direct Capturing Global Substrates of Post-Translational Modifying Enzymes in Living Cells
The potential and capability of PTM-mechanism-guided direct capturing global substrates presents an exciting prospect but yet largely unexplored. In a study published in Nature...
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Researchers Develop Probe for In-Depth N-Terminomics Detection
Proteolysis , an essential and irreversible process conducted by proteases , is fundamental to a wide range of biological functions .The utilization of the 2PCA-Probe as a tool ...