Self-Assembling Glycopeptide Defeats Superbugs by Disrupting Cell Structures and Virulence Pathways

Antimicrobial resistancerepresents an escalating global health crisis, responsible for an estimated 1.27 million deaths directly caused by resistant infections in 2019 and nearl...

Scientists Discover Lysine-Targeting Covalent Inhibitors via DNA-Encoded Chemical Library Selection Platform Guided by Proteome-Wide Data

Covalent drugs function by forming covalent bonds with specific amino acid residues, enabling sustained modulation of target proteins.

Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Inhibitor designFirst-in-class inhibitor design based on the first crystal structure of MPXV I7L proteaseContact:JIANG QinglingShanghai Institute of Materia Medica, Chinese Acad...