Studies Decoding Dimerization and Antidepressant Recognition at Noradrenaline Transporter

Noradrenaline transporter , also known as the norepinephrine transporter ( NET ) , is a member of the monoamine transporters ( MATs ) family , which also includes serotonin transporter ( SERT ) and dopamine transporter ( DAT ) .These transporters ...

2024-05-21 All →

Researchers Reveal Dynamic Regulation of Ubiquitin Ligase E6AP Activity

E6AP , the founding member of the HECT-type ubiquitin ligase family , was initially discovered for its interaction with the oncogenic protein E6 of human papillomavirus ( HPV ) .This study proposed a dynamic regulatory mechanism of E6AP activity b...

2024-04-30 All →

Spatiotemporal and Direct Capturing Global Substrates of Post-Translational Modifying Enzymes in Living Cells

The potential and capability of PTM-mechanism-guided direct capturing global substrates presents an exciting prospect but yet largely unexplored. In a study published in Nature Communications on February 17 .The concept of direct capturing substr...

2024-04-07 All →

Researchers Develop Probe for In-Depth N-Terminomics Detection

Proteolysis , an essential and irreversible process conducted by proteases , is fundamental to a wide range of biological functions .The utilization of the 2PCA-Probe as a tool for identifying N-terminal chemical labeling marked a pivotal point in...

2024-03-14 All →

Researchers Reveal Comprehensive Proteogenomic Landscape of Human Small Cell Lung Cancer

Small cell lung cancer ( SCLC ) is the most malignant and deadliest subtype of lung cancer , which kills over 200000 people worldwide each year .01335 - 1 proteogenomic landscape of small cell lung cancer ( Image by SIMM ) Contact : DIAO WentongSh...

2024-01-18 All →

Researchers Uncover Molecular Mechanism of Methamphetamine Binding to Trace Amine Receptor TAAR1

Methamphetamine ( METH ) abuse is a major health concern , however , there are no FDA-approved treatments .Understanding how METH interacts with its target proteins is crucial for the development of novel medications to address drug addiction .The...

2023-11-22 All →