Researchers Develop Probe for In-Depth N-Terminomics Detection

Proteolysis , an essential and irreversible process conducted by proteases , is fundamental to a wide range of biological functions .The utilization of the 2PCA-Probe as a tool for identifying N-terminal chemical labeling marked a pivotal point in...

2024-03-14 All →

Researchers Reveal Comprehensive Proteogenomic Landscape of Human Small Cell Lung Cancer

Small cell lung cancer ( SCLC ) is the most malignant and deadliest subtype of lung cancer , which kills over 200000 people worldwide each year .01335 - 1 proteogenomic landscape of small cell lung cancer ( Image by SIMM ) Contact : DIAO WentongSh...

2024-01-18 All →

Researchers Uncover Molecular Mechanism of Methamphetamine Binding to Trace Amine Receptor TAAR1

Methamphetamine ( METH ) abuse is a major health concern , however , there are no FDA-approved treatments .Understanding how METH interacts with its target proteins is crucial for the development of novel medications to address drug addiction .The...

2023-11-22 All →

Efficient Prediction of Relative Ligand Binding Affinity in Drug Discovery

In a study published in Nature Computational Science on October 19, a team of researchers led by Prof. ZHENG Mingyue from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences developed a pairwise binding comparison ne...

2023-10-23 All →

Glucagon Receptor Structures Uncover a New Arrestin Interaction Mechanism

In a study published in Nature on August 9, a research group led by WU Beili and ZHAO Qiang at the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences (CAS) determined the cryo-electron microscopy (cryo-EM) structures of...

2023-08-08 All →

Chinese Scientists Discover Conserved and Druggable Pocket for Small Molecule Agonists in Class B GPCRs

In a study published in Nature on July 31, teams of researchers led by H. Eric XU (XU Huaqiang) and ZHAO Lihua from the Shanghai Institute of Materia Medica (SIMM), theChinese Academy of Sciences (CAS), made a breakthrough discovery in the activat...

2023-07-31 All →